The potential mechanism of Chebulae Fructus in the treatment of hepatocellular carcinoma on the basis of network pharmacology

Jiang, Jialu; Yang, Zhiping; Hou, Guoxin; Yao, Xuming; Jiang, Jin

doi:10.1016/j.aohep.2022.100701

Cited by 3 publications

(2 citation statements)

References 26 publications

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“…Both traditional and modern research have demonstrated the potential of the herbal medicine Chebulae Fructus in treating HCC (Bag et al, 2013;Jiang et al, 2022). Nevertheless, the impacts and mechanisms by which CFE affects HCC have yet to be fully comprehended.…”

Section: Overexpression Of Apj Attenuates Cfe's Anti-hcc Effectsmentioning

confidence: 99%

“…Modern medical researches have shown that the aqueous extract of Chebulae Fructus (CFE) exhibits notable inhibitory ability on the proliferation of various cancer cells, including osteosarcoma, lung cancer, prostate cancer, and breast cancer cells (Saleem et al, 2002;Shendge et al, 2020). A recent study based on network pharmacology has explored the active constituents and potential mechanisms of CFE in addressing HCC (Jiang et al, 2022). However, further study is required to comprehensively understand the impacts and mechanisms of CFE against HCC.…”

Section: Introductionmentioning

confidence: 99%

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The extract of an herbal medicine Chebulae fructus inhibits hepatocellular carcinoma by suppressing the Apelin/APJ system

Liu,

Wang,

Zhang

et al. 2024

Front. Pharmacol.

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Introduction: Hepatocellular carcinoma (HCC) has been a highly common and pathological disease worldwide, while current therapeutic regimens have limitations. Chebulae Fructus, a common herbal medicine in Asia, has been documented to exert potential therapeutic effects on HCC in ancient medicine clinical practice. However, the molecular mechanism underlying its inhibitory effects on HCC requires further investigation.Methods: In this study, the anti-HCC effect of the aqueous extract of Chebulae Fructus (CFE) on human HCC and its underlying mechanism were evaluated. Assays including CCK8, EdU staining, crystal violet staining, cell clone formation, flow cytometry, wound healing, and transwell were used in vitro. The cell-derived xenograft (CDX) and patient-derived xenograft (PDX) models were used in vivo. Transcriptomics analysis, qRT-PCR, ELISA, IHC staining, and Western blotting were employed to determine the mechanism of action of CFE.Results: The results demonstrate that CFE effectively suppressed the proliferation and activity of HepG2 and PLC/PRF/5 HCC cells. CFE also induced apoptosis, and suppressed the migration and invasion abilities of these cells. Furthermore, CFE exhibited inhibitory effects on tumor growth in both H22 and PLC/PRF/5 mouse models, as well as in an HCC PDX model which is derived from patient tumor samples. Moreover, it was identified that CFE treatment specifically suppressed the Apelin/APJ system in HCC cells and tumor tissues. To investigate the role of the Apelin/APJ system in mediating the effects of CFE treatment, an APJ overexpressed cell model is established. Interestingly, it was found that the overexpression of APJ significantly diminished the inhibitory effects of CFE on HCC in vitro.Discussion: Collectively, this study provides compelling evidence that CFE exerts significant anti-HCC effects in cell and animal models. Moreover, our findings suggest that the Apelin/APJ system may play a vital role in the therapeutic effects of CFE against HCC.

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Section: Overexpression Of Apj Attenuates Cfe's Anti-hcc Effectsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The extract of an herbal medicine Chebulae fructus inhibits hepatocellular carcinoma by suppressing the Apelin/APJ system

Liu,

Wang,

Zhang

et al. 2024

Front. Pharmacol.

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Enclosed is the Manuscript Entitled “ Mechanism of Action of Terminalia Chebula Retz. Aqueous Extracts Against Gastric Cancer Involve Innate Immunity and Suppression of Caspase-1/Gsdmd ”

Wang

Chang

et al. 2023

Preprint

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The therapeutic mechanism of Chebulae Fructus in the treatment of immunosuppression in Chinese yellow quail on the basis of network pharmacology

Wang

et al. 2023

Front. Vet. Sci.

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IntroductionChebulae Fructus (Terminalia chebula Retz.) is a well-known traditional Chinese medicine (TCM), one of the family Combretaceae, whose immature fruit is called Fructus Chebulae Immaturus or Zangqingguo. This present study aimed at detecting the target and therapeutic mechanism of Chebulae Fructus against immunosuppression through network analysis and experimental validation.MethodsEffective components and potential targets of Chebulae Fructus were Search and filtered through the Chinese herbal medicine pharmacology data and analysis platform. A variety of known disease target databases were employed to screen the therapeutic target proteins against immunosuppression and thus constructing a protein-protein interaction network. Hub genes and key pathways in this study were identified by continuous project enrichment analysis. Further, the core targets and therapeutic mechanism of Chebulae Fructus against immunosuppression in Chinese yellow quail through animal experiment.ResultsSeventy-five identifiable major candidate targets of Chebulae Fructus were found and thus constructing a drug-compound-target-disease network. Targets derived from gene enrichment analysis play pivotal roles in lipid and atherosclerosis, fluid shear stress and atherosclerosis, and the hepatitis B pathway. Height of plicate and areas of lymphoid follicle were both increased and the expression of GATA-3 and T-bet was upregulated in Chinese yellow quail fed with Chebulae Fructus in animal experiment.ConclusionChebulae Fructus may be a helpful Chinese medicine with immunosuppressive effect and prospective applications in future. Further research is also needed to understand the mechanisms of immunosuppression and the mechanism of action of immunomodulators.

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The potential mechanism of Chebulae Fructus in the treatment of hepatocellular carcinoma on the basis of network pharmacology

Cited by 3 publications

References 26 publications

The extract of an herbal medicine Chebulae fructus inhibits hepatocellular carcinoma by suppressing the Apelin/APJ system

The extract of an herbal medicine Chebulae fructus inhibits hepatocellular carcinoma by suppressing the Apelin/APJ system

Enclosed is the Manuscript Entitled “ Mechanism of Action of Terminalia Chebula Retz. Aqueous Extracts Against Gastric Cancer Involve Innate Immunity and Suppression of Caspase-1/Gsdmd ”

The therapeutic mechanism of Chebulae Fructus in the treatment of immunosuppression in Chinese yellow quail on the basis of network pharmacology

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