The Potential Modulatory Effect of Rutin on Titanium Dioxide Nanoparticles-Induced Renal Injury in Male Mice

Abstract

Objective: This study aimed to investigate the possible protective effect of rutin in management of TiO2NPs-induced renal injury in mice.
 Methods: Forty male Swiss albino mice were randomly divided into four groups (n=10). Group (I) served as a control group, group (II) received 100 mg/kg body weight (b. wt) of rutin (orally), group (III) received 70 mg/kg b. wt of TiO2NPs,injected intraperitoneally (i. p.), Group (IV) received 70 mg/kg b. wt of TiO2NPs plus 100 mg/kg b. wt of rutin; for 14 successive days. The renal toxicity was determined through evaluating the renal function biomarkers (serum creatinine, urea, and uric acid) and the levels of malondialdehyde (MDA), reduced glutathion (GSH), nuclear factor kappa B (NF-kB), tumor necrosis factor-α (TNF)-α, B-cell lymphoma (BCL)-2 and caspase-3 in renal tissues.
 Results: Administration of TiO2NPs plus rutin prevented the deleterious effect of TiO2NPs on mice kidneys through improving the renal functions, and alleviating the increase in MDA, NF-kB, TNF-α, and caspase-3 levels, as well as the decrease in GSH andBCL-2 levels, in renal tissues.
 Conclusion: Taken together, these findings suggested that rutin plays a role in alleviating TiO2NPs-induced oxidative stress, inflammation, and apoptosis, and exerts renal protective effects.

Chemotherapeutic Potential of Novel Xanthone Sourced From Swertia Chirata Against Skin Carcinogenesis

“…The toxic nature of present anticancer drugs has led to a search for novel drugs that are selectively toxic to cancer cells [16]. There is a marked increase in the number of anticancer drugs of plant origin as they are found to be potentially non-toxic [17,18], which are tested on cells (including various cancer cell lines) [19] and experimental animals after purification and then sent to clinical trials [20]. From 2006 to 2014, there was a significant increase in the number of newly discovered anticancer molecules from 50,000 to 3,26,000, among which 1,76,000 failed to show selective toxicity [21].…”