The potential modulatory role of herbal additives against Cd toxicity in human, animal, and poultry: a review

Khafaga, Asmaa F.; El‐Hack, Mohamed E. Abd; Taha, Ayman E.; Elnesr, Shaaban S.; Alagawany, Mahmoud

doi:10.1007/s11356-018-4037-0

Cited by 74 publications

(33 citation statements)

References 68 publications

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“…In Pakistan, meat from poultry is about 32.7% of the total meat available in the country for human consumption [4]. Due to the existence of anti-nutritional agents and toxins in diets, the poultry industry faces many problems, such as suppressed growth rates, feed efficiency, and higher mortality rates [5]. Fungus spoilage is the main factor that deteriorates the hygiene of poultry feed [6].…”

Section: Introductionmentioning

confidence: 99%

The Biodegradation Role of Saccharomyces cerevisiae against Harmful Effects of Mycotoxin Contaminated Diets on Broiler Performance, Immunity Status, and Carcass characteristics

Arif

Iram

Bhutta

et al. 2020

Animals

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A feeding trial (35 days) was carried out to investigate the effect of Saccharomyces cerevisiae cell wall as a mycotoxin biodegradation agent on the performance, feed efficiency, carcass traits, and immunity response against diseases in broilers fed aflatoxin B1 contaminated diets. For this purpose, 200 one day old broilers were randomly allotted into four groups, each with five replicates (10 birds per replicate). Four starter and finisher experimental rations were formulated by using (A) 0, (B) 1.25, (C) 2.5, and (D) 3.75 g kg−1 of Saccharomyces cerevisiae. Experimental diets were contaminated with aflatoxin B1 (100 ppb kg−1 diet). The experimental chicks were kept under standard managerial conditions, and the vaccination program was followed against infectious bursal disease (IBD), infectious bronchitis (IB), and Newcastle disease (ND) diseases. At the end of the feeding trial, carcass, organ weight, and blood samples were collected randomly to determine the carcass traits and antibody titer against ND and IBD viruses. Throughout the experiment, the addition of 3.75 g kg−1 of the Saccharomyces cerevisiae cell wall (Group-D) in feed resulted in the highest weight gain, final weight, feed intake, and the lowest FCR values followed by C group compared with the other groups. All carcass traits were significantly (p > 0.05) improved by increasing the inclusion levels of Saccharomyces cerevisiae in broiler diets. It could be concluded that the broiler diet supplemented with 2.5 or 3.75 g kg−1 of Saccharomyces cerevisiae as a biodegrading agent resulted in improved growth performance, immunity activity and carcass traits, and supplementation with Saccharomyces cerevisiae at these levels can be used effectively in broiler diets without negatively affecting bird health status.

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Section: Introductionmentioning

confidence: 99%

The Biodegradation Role of Saccharomyces cerevisiae against Harmful Effects of Mycotoxin Contaminated Diets on Broiler Performance, Immunity Status, and Carcass characteristics

Arif

Iram

Bhutta

et al. 2020

Animals

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“…It is for these reasons that Cd is found in almost everything we eat, drink, and breathe ( Thompson and Bannigan, 2008 ). Continuous exposure to low levels of Cd leads to its deposition in different tissues day after day, causing toxic effects on various organs ( Khafaga et al., 2019 ). Its chemical similarity to some nutritive metals enables it to mimic and displace the metals in various biological structures ( Ghosh and Thomas, 1995 ).…”

Section: Introductionmentioning

confidence: 99%

Histological changes, lipid metabolism, and oxidative and endoplasmic reticulum stress in the liver of laying hens exposed to cadmium concentrations

Zhu

Bai

et al. 2020

Poultry Science

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The objective of this study was to determine the effects of cadmium ( Cd ) on histological changes, lipid metabolism, and oxidative and endoplasmic reticulum ( ER ) stress in the liver of layers. A total of 480 hens at 38 wk of age were randomly assigned in 5 groups that were fed a basal diet or basal diet supplemented with CdCl 2 2.5H 2 O at 7.5, 15, 30, and 60 mg Cd/kg feed for 9 wk. The results showed that accumulation of Cd was the greatest in the kidney, followed by the liver, pancreas, and lung. Diet contaminated with 30 mg Cd/kg induced antioxidant defenses accompanied by the increase of the activities of antioxidant enzymes in the liver, while dietary supplementation with 60 mg Cd/kg decreased the antioxidant levels significantly ( P < 0.05). Immunofluorescence assay showed Cd induced reactive oxygen species production and endoplasmic reticulum stress in hepatocytes. Exposure to 60 mg Cd/kg significantly upregulated the expression of cytochrome C, caspase 3, caspase 9, caspase 7, Grp78, and Chop ( P < 0.05). Histopathology and quantitative real-time PCR results presented periportal fibrosis, bile duct hyperplasia, and periportal inflammatory cell infiltration in the liver accompanied by upregulating the expression of tumor necrosis factor-α, IL-6 and IL-10 in the 30- or 60-mg Cd/kg groups. Oil Red O staining and RT-qPCR results showed dietary supplementation with 7.5, 15, and 30 mg Cd/kg promoted the synthesis of lipid droplets and upregulated the expression of fatty acid synthase, while dietary supplementation with 60 mg Cd/kg attenuated the synthesis of lipid droplets and downregulated the expression of acyl-CoA oxidase 1, carnitine palmitoyltransferase-1, and perixisome proliferation-activated receptor α ( P < 0.05). Besides, the expression of vitellogenin ( VTG ) II and microsomal triglyceride transfer protein were upregulated in the 7.5-mg Cd/kg group, and the expressions of apolipoprotein B, vitellogenin II, and apolipoprotein very-low-density lipoprotein-II were downregulated in the 30- and/or 60-mg Cd/kg groups ( P < 0.05). Conclusively, although low-dose Cd exposure promoted the synthesis of lipids and lipoproteins in the liver, the increase of Cd exposure could trigger liver injury through inducing oxidative and endoplasmic reticulum stress and negatively affect lipid metabolism and yolk formation in laying hens.

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“…Recently, poultry breeders and nutritionists have tried to avoid the use of synthetic dietary feed additives, as most of these additives lead to performance and health problems in broiler chickens (Abdelnour, Abd El‐Hack, Arif, Khafaga, & Taha, ; Pourhossein et al, ; Shewita & Taha, ). Natural feed additives have emerged as alternatives to synthetic additives (Abdelnour, Abd El‐Hack, Khafaga, et al, ; Khafaga, Abd El‐Hack, Taha, Elnesr, & Alagawany, ). There is evidence that suggests that some herbs, spices and plant extracts have antioxidant activities, antimicrobial effects and stimulating effects on the digestive system (Hashemi, Zulkifli, Davoodi, Zunita, & Ebrahimi, ; Khafaga & Bayad, , ).…”

Section: Introductionmentioning

confidence: 99%

Effects of supplementing broiler diets with coriander seed powder on growth performance, blood haematology, ileum microflora and economic efficiency

Taha

Hassan

Shewita

et al. 2019

Animal Physiology Nutrition

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A total of 480 one‐day‐old Arbor Acres broiler chicks were randomly assigned to four dietary groups, each including six replicates (n = 20/replicate). Broilers in the first group (G1) were fed a basal diet without any additives (control). Broilers in groups 2, 3 and 4 (G2, G3 and G4) were fed a basal diet supplemented with 0.1%, 0.2% and 0.4% coriander (Coriandrum sativum L.) seed powder (CSP) respectively. Feeding trials lasted for 42 days, and after that growth, carcass traits, haematological parameters, gut microbiota and economic efficiency (EE) were evaluated. Final body weight (FBW), total weight gain (TWG), total feed intake (TFI) and red blood cell (RBC) counts of broilers in the G4 and G3 treatment groups were significantly higher (p < .05) compared with broilers in the G1 treatment group. The feed conversion ratio (FCR) was better (p < .05) in the G4 treatment group (1.72) than in the G1 treatment group (1.84). Broilers in CSP treatment groups had significantly higher haemoglobin (Hb) concentrations, packed cell volume (PCV) and platelet counts, and had lower (p < .05) Escherichia coli and Clostridium perfringens counts compared with broilers in the G1 treatment group. Dressing, liver, pancreas, bursa and thymus percentages were higher (p < .05) in broilers in the G4 (70.30, 3.18, 0.31, 0.10 and 0.32% respectively) treatment group, compared with broilers in the control (G1) group (66.57, 2.37, 0.23, 0.04 and 0.21% respectively). Broilers in treatment groups G4 and G3 had lower percentages of abdominal fat and lower total bacterial counts (p < .05) than broilers in treatment groups G2 and G1. The highest economic efficiency (EE) was found in treatment group G4, and EE in this group was 13.06% greater than in the control (G1) group.

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The potential modulatory role of herbal additives against Cd toxicity in human, animal, and poultry: a review

Cited by 74 publications

References 68 publications

The Biodegradation Role of Saccharomyces cerevisiae against Harmful Effects of Mycotoxin Contaminated Diets on Broiler Performance, Immunity Status, and Carcass characteristics

The Biodegradation Role of Saccharomyces cerevisiae against Harmful Effects of Mycotoxin Contaminated Diets on Broiler Performance, Immunity Status, and Carcass characteristics

Histological changes, lipid metabolism, and oxidative and endoplasmic reticulum stress in the liver of laying hens exposed to cadmium concentrations

Effects of supplementing broiler diets with coriander seed powder on growth performance, blood haematology, ileum microflora and economic efficiency

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