The Potential Neuroprotective Effect of Cyperus esculentus L. Extract in Scopolamine-Induced Cognitive Impairment in Rats: Extensive Biological and Metabolomics Approaches

Saeed, Marwa M.; Fernández-Ochoa, Álvaro; Saber, Fatema R.; Sayed, Rabab H.; Cádiz-Gurrea, María de la Luz; Elmotayam, Amira K.; Leyva-Jiménez, Francisco Javier; Segura‐Carretero, Antonio; Nadeem, Rania I.

doi:10.3390/molecules27207118

Cited by 9 publications

(2 citation statements)

References 96 publications

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“…5). In a similar study, administration of Cyperus esculentus L (Tiger nut) extract on scopolamine induced rats results in gliosis reduction in the coronal brain section thus indicating its possible neuroprotective function [37].…”

Section: Discussionmentioning

confidence: 88%

Neuroprotective Effects of Carotenoid Rich Verbesina encelioides Flower Extract in Scopolamine Induced Memory Impaired Rats Mimicking Alzheimer’s Disease

Dey,

Srivastava,

Sharma

et al. 2024

Preprint

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Neuron degeneration is the most common old age complications worldwide. Alzheimer's disease (AD) is one of the most common neurodegenerative condition with limited drug options and significant adverse effects. Hence, there is a growing interest in exploring natural products for their potential pharmacological activities against AD. This study investigates the efficacy of Verbesina encelioides flower extract (VFE) in alleviating neurobehavioral damage induced by Scopolamine in rat mimicking AD model. GC-MS analysis showed that V. encelioides flower extract is rich in carotenoids like spirilloxanthin. Various behavioural models were used to assess the rats' learning and memory capabilities. Additionally, biochemical tests were conducted on the AD rat models to evaluate oxidative stress in the brain, including superoxide dismutase (SOD), nitric oxide (NO), reduced glutathione (GSH), and anti-acetylcholinesterase (AChE) enzyme assays. Findings from this study suggest that the VFE significantly improved the rats' cognitive aptitude and alleviated them from oxidative stress by reducing free radical generation. Based on the results obtained from GC-MS analysis, in silico interaction analysis of gingkolide A and spirilloxanthin with acetylcholinesterase was carried out. In summary, this study suggests that V. enceloides flower extract improves learning abilities and mitigates cognitive deficits caused by scopolamine. Thus V. enceloides could be potentially seen as natural therapeutic intervention against neurodegenerative disorders likes Alzheimer’s disease and dementia.

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Section: Discussionmentioning

confidence: 88%

Neuroprotective Effects of Carotenoid Rich Verbesina encelioides Flower Extract in Scopolamine Induced Memory Impaired Rats Mimicking Alzheimer’s Disease

Dey,

Srivastava,

Sharma

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

“…References: 1[43], 2[44], 3[45,46],4 [47], 5[48],6 [49],7 [50],8 [51],9 [52],10 [53],11 [54], 12[55].Stresses 2024, 4, FOR PEER REVIEW 4…”

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Functional and Qualitative Metabolic Compounds in the Twigs of the Deciduous Mistletoe Loranthus europaeus Jacq.

Bampali,

Karoutzou,

Katsarou

et al. 2023

Stresses

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In this study, a detailed phytochemical investigation of compounds in the twigs of the mistletoe Loranthus europaeus Jacq., which belongs to the Loranthaceae family, is presented. Specimens were collected from the mistletoe L. europaeus growing on oak trees in the mainland of Greece. The alliance of oaks and mistletoes became a symbol of knowledge and strength for many centuries. Although numerous compounds of aerial tissues of other mistletoes, e.g., Viscum album, have been published, few studies have been conducted to investigate the metabolic and physiological traits of the hemiparasitic, deciduous Loranthus europaeus. LC-HRMS-based analysis led to a detailed characterization of ethyl acetate and dichloromethane extracts of the twigs of L. europaeus, which, to the best of our knowledge, exhibit enhanced antioxidant potential. Hence, twenty-four and twenty-six compounds were tentatively identified from the ethyl acetate and dichloromethane twigs’ extracts, respectively; these compounds belong to fatty acids, flavonoids, and flavonoid glycosides. Also, chlorophyll, soluble sugar, starch, and lipid contents in the twigs of L. europaeus, which have not hitherto been published, were investigated.

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A review on the biological and bioactive components of Cyperus esculentus L.: insight on food, health and nutrition

Edo,

Samuel,

Nwachukwu

et al. 2024

J Sci Food Agric

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Tiger nut (Cyperus esculentus L.) is a small, tuberous root vegetable that has gained increasing attention in recent years due to its potential health benefits. This review article provides an elaborate overview of tiger nut, including its botany, historical uses, nutritional composition, potential health benefits and traditional medicinal uses. This review article comprehensively discusses the nutritional profile of tiger nut, providing a detailed understanding of its nutrient content. Furthermore, the potential health benefits of tiger nut are thoroughly reviewed, including its effects on digestive health, cardiovascular health, blood sugar control, immune function and other potential therapeutic uses. Scientific articles used for this review were retrieved from ScienceDirect, Google Scholar, PubMed and SciELO databases. Only articles published between 1997 and 2022 were used for research. This review contributes to a better understanding of tiger nut and its prospective uses in functional foods and medicine by combining the available scientific material. © 2024 Society of Chemical Industry.

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The Potential Neuroprotective Effect of Cyperus esculentus L. Extract in Scopolamine-Induced Cognitive Impairment in Rats: Extensive Biological and Metabolomics Approaches

Cited by 9 publications

References 96 publications

Neuroprotective Effects of Carotenoid Rich Verbesina encelioides Flower Extract in Scopolamine Induced Memory Impaired Rats Mimicking Alzheimer’s Disease

Neuroprotective Effects of Carotenoid Rich Verbesina encelioides Flower Extract in Scopolamine Induced Memory Impaired Rats Mimicking Alzheimer’s Disease

Functional and Qualitative Metabolic Compounds in the Twigs of the Deciduous Mistletoe Loranthus europaeus Jacq.

A review on the biological and bioactive components of Cyperus esculentus L.: insight on food, health and nutrition

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