The potential of alkaloids in drug discovery

Cordell, Geoffrey A.; Quinn-Beattie, Mary Lou; Farnsworth, Norman R.

doi:10.1002/ptr.890

Cited by 328 publications

(226 citation statements)

References 118 publications

(118 reference statements)

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“…Moreover, thiazepine type alkaloids are rare in nature and most of the synthesized thiazepine rings were of 1,4-type and fused with benzene, phenyl…etc. and were free of carbohydrate [11][12][13].…”

Section: Resultsmentioning

confidence: 99%

Rubiothiazepine a Novel Unusual Cytotoxic Alkaloid from Ixora undulata Roxb. Leaves

Mohammed¹

2014

Nat Prod Chem Res

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Leaves of Ixora undulata Roxb. were investigated phytochemically for the first time for its alkaloidal content, which resulted in the isolation of a novel unusual thiazepine alkaloid glycoside identified as 7-[(β-D-glucopyranosyl)oxy]-6-hydroxy-2-methoxy-4,5-dihydro-1,3-thiazepine and trivially named as Rubiothiazepine. Its structure was determined on the basis of 1D and 2D NMR ( 1 H-, 13 C-NMR, 1 H-1 H COSY, 1 H-13 C HETCOR, 1 H-13 C HMBC, 1 H-15 N HMBC and DIFNOE), high resolution ESI-CID-MS/MS, UV and IR spectroscopy. The isolated compound showed cytotoxic activity against EL 4 (Murine Leukemia) with IC 50 >100 µg/mL, and also showed cytotoxic and HIV-1 activity against MT-4 and HIV-1IIIB with CC 50 >100 µg/mL and EC 50 >100 µg/mL, respectively.

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Section: Resultsmentioning

confidence: 99%

Rubiothiazepine a Novel Unusual Cytotoxic Alkaloid from Ixora undulata Roxb. Leaves

Mohammed¹

2014

Nat Prod Chem Res

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“…Two simple examples will illustrate how, without much effort, a whole different dimension of natural products discovery for health care might be envisaged. These examples are alkaloids 35 and ethnopharmacology 1 .…”

Section: Developing a Future Visionmentioning

confidence: 99%

“…For the alkaloids, the situation is even more disturbing 35 . While alkaloids comprise about 15.2% of the structures of known natural products, they provide 46% of the plant-derived pharmaceuticals.…”

Section: Developing a Future Visionmentioning

confidence: 99%

“…In addition, for those alkaloids which have been subjected to bioassays in more than 20 biological categories over 33% are single agent drugs. Yet, very distressingly, 76% of all known alkaloids have never been tested in a single bioassay 35 . The same is probably true of many natural product compound groups such as flavonoids, coumarins, lignans, steroids, and acetogenins.…”

Section: Developing a Future Visionmentioning

confidence: 99%

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Natural products in a world out-of-balance

Cordell¹,

Colvard²

2006

Arkivoc

Self Cite

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Dedicated to Professor Atta-ur-Rahman, FRS in recognition of his outstanding contributions to natural products chemistry and society, locally and globally on the auspicious occasion of his 65 th birthday AbstractThe natural world is careening out of balance in many different ways. Uncontrolled population growth, global warming, loss of biodiversity, and emerging new diseases, has fostered increasing drug resistance, dependence on synthetic chemicals and drugs, unregulated natural medicines, abused natural products, and the use of natural products as agents of mass intimidation, incapacitation, and death. This is not a sustainable situation for the planet. Plants are the basis of the ecological homeostasis of Earth and its' living organisms, including the human species, and plant-based medicinal agents are used world-wide by humans and animals to treat a myriad of ailments. But, how will quality human health care, particularly in the form of locally sustainable medicinal agents, be delivered to a burgeoning global population?

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“…The presence of heterocycles in all kind of organic substances have much interest in biology, optics, pharmacology, biology, electronics, material sciences etc. Many natural drugs such as papaverine, theobromine, quinine, emetine, theophylline, atropine, procaine, codeine, reserpine and morphine [2][3][4] contain heterocyclic nucleus in their structure. Heterocycles are chemically more flexible and better able to respond to many demands of biochemical systems.…”

Section: Introductionmentioning

confidence: 99%

Quinoline Derivatives: In Vitro Antimicrobial Study

Baluja¹,

Chanda²,

Moteriya³

et al. 2017

JPP

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Some quinoline derivatives were synthesized and their structures were confirmed by IR, 1 H NMR and mass spectroscopy. Screening of all these synthesized compounds were done in vitro against four Gram positive bacteria, four Gram negative bacteria and four fungal strains in dimethyl sulphoxide and N, N-dimethyl formamide. It is observed that N, N-dimethyl formamide is good solvent for the these compounds in selected strains and compounds containing cyano and nitro groups are more effective in inhibiting these strains.

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The potential of alkaloids in drug discovery

Cited by 328 publications

References 118 publications

Rubiothiazepine a Novel Unusual Cytotoxic Alkaloid from Ixora undulata Roxb. Leaves

Rubiothiazepine a Novel Unusual Cytotoxic Alkaloid from Ixora undulata Roxb. Leaves

Natural products in a world out-of-balance

Quinoline Derivatives: In Vitro Antimicrobial Study

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