The Potential of Bacteriophage-Antibiotic Combination Therapy in Treating Infections with Multidrug-Resistant Bacteria

Osman, Abdul-Halim; Kotey, Fleischer C. N.; Odoom, Alex; Darkwah, Samuel; Yeboah, Raphael K.; Dayie, Nicholas T. K. D.; Donkor, Eric S.

doi:10.3390/antibiotics12081329

Cited by 21 publications

(7 citation statements)

References 128 publications

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“…Streptococcus sp HMSC067H01, an unclassified Streptococcus species, was found to be significantly reduced in COVID-19 patients and higher in controls ( Soffritti et al, 2021 ), which could explain the elevated number of Streptococcus phage in moderate disease progression. The BSAs used in this study are currently being studied for phage combination therapies ( Save et al, 2022 ; Osman et al, 2023 ).…”

Section: Discussionmentioning

confidence: 99%

Hospital antimicrobial stewardship: profiling the oral microbiome after exposure to COVID-19 and antibiotics

Buendia,

Fernandez,

Raley

et al. 2024

Front. Microbiol.

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IntroductionDuring the COVID-19 Delta variant surge, the CLAIRE cross-sectional study sampled saliva from 120 hospitalized patients, 116 of whom had a positive COVID-19 PCR test. Patients received antibiotics upon admission due to possible secondary bacterial infections, with patients at risk of sepsis receiving broad-spectrum antibiotics (BSA).MethodsThe saliva samples were analyzed with shotgun DNA metagenomics and respiratory RNA virome sequencing. Medical records for the period of hospitalization were obtained for all patients. Once hospitalization outcomes were known, patients were classified based on their COVID-19 disease severity and the antibiotics they received.ResultsOur study reveals that BSA regimens differentially impacted the human salivary microbiome and disease progression. 12 patients died and all of them received BSA. Significant associations were found between the composition of the COVID-19 saliva microbiome and BSA use, between SARS-CoV-2 genome coverage and severity of disease. We also found significant associations between the non-bacterial microbiome and severity of disease, with Candida albicans detected most frequently in critical patients. For patients who did not receive BSA before saliva sampling, our study suggests Staphylococcus aureus as a potential risk factor for sepsis.DiscussionOur results indicate that the course of the infection may be explained by both monitoring antibiotic treatment and profiling a patient’s salivary microbiome, establishing a compelling link between microbiome and the specific antibiotic type and timing of treatment. This approach can aid with emergency room triage and inpatient management but also requires a better understanding of and access to narrow-spectrum agents that target pathogenic bacteria.

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Section: Discussionmentioning

confidence: 99%

Hospital antimicrobial stewardship: profiling the oral microbiome after exposure to COVID-19 and antibiotics

Buendia,

Fernandez,

Raley

et al. 2024

Front. Microbiol.

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“…My suspicion, in fact, is that in explicit terms, this math may be less useful than can be the case for preclinical studies, if only because there is less opportunity to make the detailed measurements that many of these models require, e.g., such as of bacterial concentrations, phage titers in association with targeted bacteria, phage adsorption rate constants, phage burst sizes, etc. These are all as found in situ while treating infections caused by what are typically somewhat uncharacterized bacterial strains and, in many cases, also in combination with antibiotics [ 41 , 57 , 86 , 87 , 88 , 89 ], which can have antagonistic impacts on phage infection abilities [ 41 , 51 , 85 , 90 ]. In particular for the latter, note that of 18 clinical phage therapy studies that I was able to obtain—published in 2023 or, at the time of writing, which are published but still online ahead of print—at least 16 indicate treatments using phages in combination with antibiotics [ 57 , 91 , 92 , 93 , 94 , 95 , 96 , 97 , 98 , 99 , 100 , 101 , 102 , 103 , 104 , 105 , 106 , 107 , 108 ].…”

Section: Discussionmentioning

confidence: 99%

Automating Predictive Phage Therapy Pharmacology

Abedon

2023

Antibiotics

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Viruses that infect as well as often kill bacteria are called bacteriophages, or phages. Because of their ability to act bactericidally, phages increasingly are being employed clinically as antibacterial agents, an infection-fighting strategy that has been in practice now for over one hundred years. As with antibacterial agents generally, the development as well as practice of this phage therapy can be aided via the application of various quantitative frameworks. Therefore, reviewed here are considerations of phage multiplicity of infection, bacterial likelihood of becoming adsorbed as a function of phage titers, bacterial susceptibility to phages also as a function of phage titers, and the use of Poisson distributions to predict phage impacts on bacteria. Considered in addition is the use of simulations that can take into account both phage and bacterial replication. These various approaches can be automated, i.e., by employing a number of online-available apps provided by the author, the use of which this review emphasizes. In short, the practice of phage therapy can be aided by various mathematical approaches whose implementation can be eased via online automation.

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“…70a,96 Another way is to take alternatives to antibiotics, if there is no severe infection. There are several alternative antibiotic therapy [103][104][105][106] : i) Probiotics: Probiotics are live microorganisms (usually bacteria or yeast) that provide health benefits when consumed in adequate amounts. The mechanism of action of probiotic are as follows: a) Probiotics can restore and maintain gut microbial balance.…”

Section: Prevention and Control Of The Antibiotic Contaminationmentioning

confidence: 99%

Review on Various Antibiotic Contamination in Natural Sources: Effects on Environment Including Animals and Humans

Mandal

2024

Orient. J. Chem

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Antibiotics have been used as medicine to inhibit a large array of infections in humans, in animals and plants for nearly 100 years. Nonstop use and misapplication of antibiotics have triggered antibiotic contamination worldwide. Antibiotic contamination poses risks to microbial communities, aquatic ecosystems, and human health. If growth of antibiotic resistant bacteria occurs, then it may increase multidrug-resistant bacterial infections for the coming days, thus posing a terrific impact on human health, as well as on the ecosystem of the environment. So, proper management and awareness are crucial to mitigate the environmental impacts. In this review, the knowledge about the sources and existence of antibiotics, its side effects, contamination sources, prevention and control of antibiotics to reduce antibiotic contamination has been discussed in detail.

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The Potential of Bacteriophage-Antibiotic Combination Therapy in Treating Infections with Multidrug-Resistant Bacteria

Cited by 21 publications

References 128 publications

Hospital antimicrobial stewardship: profiling the oral microbiome after exposure to COVID-19 and antibiotics

Hospital antimicrobial stewardship: profiling the oral microbiome after exposure to COVID-19 and antibiotics

Automating Predictive Phage Therapy Pharmacology

Review on Various Antibiotic Contamination in Natural Sources: Effects on Environment Including Animals and Humans

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