The potential of bromelain enzyme as a safe anthelmintic and minimume residues for livestock commodities

Abstract

Livestock are very important as a source of food products of of animal protein source for the Indonesian people. Worm infections are an infectious disease can reduce production, quality of animal health and cause hemorrhagic lesions in the intestinal mucosal layer during migration in the tissue phase and blockages often occur if the number of worms is so large that the food absorption process is disrupted. The use of anthelmintics requires attention to the incidence of target worm resistance to the drugs used. This is important because the incidence of anthelmintic resistance is a topic and is a problem of concern throughout the world and also needs to consider residues in food products of animal origin. Bromelain is a proteolytic sulphihydryl fraction components are peroxide, acid phosphatase and several protease inhibitors to play an important role in the antihelminthic effect. In silico molecular docking analysis using USF Chimera, Protox and Swiss Docking show that bromelain has anthelmintic potential which works as a destroyer of the cuticular tegument of parasitic walls and is able to bind to astekolin in nematode worms. Bromelain can be used as an anthelmintic compound in the future that is safe and free of residue in foods of animal origin.