The potential of desferrioxamine-gallium as an anti-
            <i>Pseudomonas</i>
            therapeutic agent

Banin, Ehud; Lozinski, Alina; Brady, Keith M.; Berenshtein, Eduard; Butterfield, Phillip W.; Moshe, Maya; Chevion, Mordechai; Greenberg, E. Peter; Banin, Eyal

doi:10.1073/pnas.0808608105

Cited by 241 publications

(217 citation statements)

References 36 publications

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“…Banin et al [60] have used siderophore-metal complex combining a strong siderophore, DFO with non-radioactive gallium for the treatment of Pseudomonas aeruginosa (P.a.) infection.…”

Section: Siderophores For Molecular Imaging Of Infectionmentioning

confidence: 99%

Siderophores for molecular imaging applications

Petřík

Zhai

Haas

et al. 2016

Clin Transl Imaging

110

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This review covers publications on siderophores applied for molecular imaging applications, mainly for radionuclide-based imaging. Siderophores are low molecular weight chelators produced by bacteria and fungi to scavenge essential iron. Research on these molecules has a continuing history over the past 50 years. Many biomedical applications have been developed, most prominently the use of the siderophore desferrioxamine (DFO) to tackle iron overload related diseases. Recent research described the upregulation of siderophore production and transport systems during infection. Replacing iron in siderophores by radionuclides, the most prominent Ga-68 for PET, opens approaches for targeted imaging of infection; the proof of principle has been reported for fungal infections using 68 Ga-triacetylfusarinine C (TAFC). Additionally, fluorescent siderophores and therapeutic conjugates have been described and may be translated to optical imaging and theranostic applications. Siderophores have also been applied as bifunctional chelators, initially DFO as chelator for Ga-67 and more recently for Zr-89 where it has become the standard chelator in Immuno-PET. Improved DFO constructs and bifunctional chelators based on cyclic siderophores have recently been developed for Ga-68 and Zr-89 and show promising properties for radiopharmaceutical development in PET. A huge potential from basic biomedical research on siderophores still awaits to be utilized for clinical and translational imaging.

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“…Banin et al [60] have used siderophore-metal complex combining a strong siderophore, DFO with non-radioactive gallium for the treatment of Pseudomonas aeruginosa (P.a.) infection.…”

Section: Siderophores For Molecular Imaging Of Infectionmentioning

confidence: 99%

Siderophores for molecular imaging applications

Petřík

Zhai

Haas

et al. 2016

Clin Transl Imaging

110

View full text Add to dashboard Cite

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“…15 In other studies, da Silva et al reported on the effect of the coordination of Ga 3+ on the antibacterial activity of N(4)-phenyl-2-formylpyridine thiosemicarbazone and N(4)-phenyl-2-benzoylpyridine thiosemicarbazone against P. aeruginosa, 16 and Bernstein illustrated how solution chemistry and the versatility of bacterial metabolic networks could increase or decrease the toxicity of Ga for a pathogenic bacterium. 17 In addition to the reports on the activity of Ga ions against P. aeruginosa, 3,14 there are also several recent reports detailing the antibacterial activity of C-dots 18,19 and a C-dot-Ag nanocomposite. 20 However, to the best of our knowledge, no reports on the antibacterial activity of Ga doped in C-dots (Ga@C-dots) have been published.…”

Section: Introductionmentioning

confidence: 99%

Ga@C-dots as an antibacterial agent for the eradication of <em>Pseudomonas aeruginosa</em>

Kumar¹,

Natan²,

Jacobi³

et al. 2017

IJN

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The opportunistic pathogen Pseudomonas aeruginosa causes infections that are difficult to treat by antibiotic therapy. This research article reports on the synthesis of gallium (Ga) doped in carbon (C)-dots (Ga@C-dots) and their antimicrobial activity against free-living P. aeruginosa bacteria. The synthesis of Ga@C-dots was carried out by sonicating molten Ga (for 2.5 h) in polyethylene glycol-400, which acts as both a medium and carbon source. The resultant Ga@C-dots, having an average diameter of 9±2 nm, showed remarkably enhanced antibacterial activity compared with undoped C-dots. This was reflected by the much lower concentration of Ga doped within Ga@C-dots which was required for full inhibition of the bacterial growth. These results highlight the possibility of using Ga@C-dots as potential antimicrobial agents.

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“…Есть ряд работ, посвященных ингибированию роста Ps. aeruginosa наряду с биопленкой, форми-руемой этим микроорганизмом, в которых показаны различные пути доставки галлия в бактериальную клетку -использующие нитрит галлия Ga(NO 3 ) 3 [2] и соединение дезферриоксамина с галлием [38]. В по-следнем случае хоть и не был установлен механизм действия антибактериального агента, тем не менее желаемый эффект был достигнут -было отмечено подавле-ние инфекционного процесса, вызванного Ps.…”

Section: разрушение бактериальной клеточной стенки и нарушение внутреunclassified

Современные Экспериментальные Методы Предотвращения Бактериальной Адгезии И Нарушения Внутреннего Гомеостаза Бактерий: Обзор Литературы

Самохин¹,

Козлова²,

Корнеев³

et al. 2017

IJAFR (МЖПФИ)

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В настоящем обзоре рассмотрены два направления по предотвращению бактериальных инфекций: предотвращение адгезии к защищаемой поверхности, а также разрушение бактериальной клеточной стенки с нарушением/повреждением систем поддержания внутреннего гомеостаза бактерий. Показаны существу-ющие проблемы в части защиты имплантатов путем нанесения на них разного рода покрытий, обладающих бактерицидным либо бактериостатическим действием, в качестве которых могут выступать катионы ме-таллов, наночастицы, полиэлектролитных многослойных покрытий. Рассмотрены ограничения, связанные с возможностью использования ионов серебра в прикладных клинических применениях, наряду с освеще-нием вопросов, касающихся их токсичности. Дано представление о различных ингибиторах эффлюксных насосов бактерий, экспериментальных работах по извращению метаболизма бактерий в рамках концепции «троянского коня» путем подмены ионов, участвующих в окислительно-восстановительных реакциях. Также представлены сведения об ингибиторах систем межмикробных взаимодействий (quorum sensing inhibitors) и о перспективности попыток создать антимикробные средства, выключающие указанные системы и/или нарушающие их работу. In the present review two different classes of prevention of the bacterial infection were summarized, with aim to adhesion prevention to the target surface, destruction of the bacterial cell wall with mechanisms of impairment of the bacterial cell internal homeostasis. Current disadvantages in the implant protective coatings with bactericide or bacteriostatic action are reviewed (metal ions, nanoparticles, polyelectrolyte multilayered coatings), silver ions toxicity and limitations of its use in medicine was discussed. Paper also presented data on a different efflux pump inhibitors, experimental studies on induction of impairment in the bacterial metabolism («Trojan horse» concept), for example, replacement of an ions that plays crucial role in the redox reactions; quorum sensing inhibitors are reviewed with focus on the perspectives of antimicrobials on its basis.

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The potential of desferrioxamine-gallium as an anti- Pseudomonas therapeutic agent

Cited by 241 publications

References 36 publications

Siderophores for molecular imaging applications

Siderophores for molecular imaging applications

Ga@C-dots as an antibacterial agent for the eradication of <em>Pseudomonas aeruginosa</em>

Современные Экспериментальные Методы Предотвращения Бактериальной Адгезии И Нарушения Внутреннего Гомеостаза Бактерий: Обзор Литературы

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