The Potential of Flavonoids and Tannins from Medicinal Plants as Anticancer Agents

Teodor, Eugenia Dumitra; Ungureanu, Oana; Gatea, Florentina; Radu, Gabriel Lucian

doi:10.2174/1871520620666200516150829

Cited by 35 publications

(20 citation statements)

References 137 publications

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“…The already published results of research on potential pharmaceutical and medical applications of tannins point out to their positive effect on the functionality of intestinal as well as to anticancer, anti-inflammatory, anti-allergic or antiviral activity [ 43 , 50 , 51 , 56 , 64 , 65 , 66 , 67 , 68 , 69 ]. The specific properties of tannins that enable their irreversible binding to proteins make them also a useful weapon against microorganisms.…”

Section: Antifungal Substances Of Plant Originmentioning

confidence: 99%

Natural Compounds for Wood Protection against Fungi—A Review

Broda

2020

Molecules

130

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Wood is a renewable, versatile material with multiple applications and the largest terrestrial pool of sequestered carbon. However, it is susceptible to degradation, mainly caused by wood-decaying fungi. Since several traditional wood preservatives have been banned owing to their detrimental effects on humans and the environment, extending the lifespan of wood products using new generation natural preservatives is an imperative from the perspectives of human health and environmental protection. Several natural compounds of plant and animal origin have been tested for their fungicidal properties, including essential oils, tannins, wood extractives, alkaloids, propolis or chitosan; and their enormous potential in wood protection has been shown. Although they are not free of limitations, the potential methods to overcome their drawbacks and enhance their bioactivity already exist, such as co-impregnation with different polymers, cross-linkers, metal chelators or antioxidants. The presence of the discrepancies between laboratory tests and the field performance, as well as legislation-related problems resulting from the lack of standards defining the quality and performance of natural protective formulations, however, create an urgent need for further thorough research and arrangements. The collaboration with other industries interested in the utilisation of natural active compounds will reduce the associated costs, thus, will facilitate the successful implementation of alternative antifungal agents.

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Section: Antifungal Substances Of Plant Originmentioning

confidence: 99%

Natural Compounds for Wood Protection against Fungi—A Review

Broda

2020

Molecules

130

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“…Meanwhile, 3 similar wood samples contained slight tannin compounds. These compounds are obtained from various plant extracts, which possess anti-cancer and anti-microbial properties [53,54]. Based on the results, the different lianas types used by the Kaili tribe were detected to contain tannin used as kidney, cancer, and tumor medicines.…”

Section: Taninmentioning

confidence: 99%

“…Although several studies have reported that relatively 1.5 to 23% are also found in plant roots, it is also found in leaves [58]. Saponin compounds in various medicinal plants have been globally proven to possess anti-cancer and other pharmacological properties [54,59].…”

Section: Saponinmentioning

confidence: 99%

Ethnopharmacology and Antioxidant Activity Studies of Woody Liana Original Wallacea

Hapid¹,

Napitupulu²,

Zubair³

2021

IJDNE

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Lore Lindu National Park is a habitat located in the middle of the Wallacea Region, consisting of various types of medicinal plants, including lianas. This area is surrounded by the Kaili Tribe, which possesses adequate ethnopharmacology knowledge and local wisdom in managing living natural resources. Studies on the medicinal plant species of lianas original Wallacea have not been conducted. Therefore, this study aims to reveal Kaili’s ethnopharmacology of woody liana plants and identify the metabolic content and antioxidant activity. This study was carried out at the Lore Lindu National Park with the purposive and snowball sampling methods used to determine the respondents. Furthermore, the Harborne and 2,2-diphenyl-1-picrylhydrazyl (DPPH) methods were used to analyze the phytochemical content and antioxidant activities. The results showed that the Kaili people used the lianas Poikilospermum suaveolens (Blume) Merr, Arcangelisia Flava (L.) Merr, Fibrauea Tinctoria Lour, and Maclura cochinchinensis (Lour.) Corner are medicine for treating various types of chronic diseases. The plant's bark and wood are used as medicine by processing boiled/brewed hot water, or by pounded, and smeared over the wound. The phytochemical analysis results showed that alkaloids are contained in all types of lianas, while flavonoids and tannins are found only in 3 types. Meanwhile, the P. suaveolens contained saponin, A. flava bark extract has potential to be developed as an antioxidant.

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“…Natural compounds and antioxidants are no exception, and are superior to synthetic compounds with their exceptionally broad activity [ 370 , 371 ]. A large number of these compounds are at various stages of clinical and preclinical research [ 365 , 372 ].…”

Section: Natural Compounds and Important Targets Associated With Chronic Inflammation And Oxidative Stress In Cancer Treatmentmentioning

confidence: 99%

Therapeutic Influence on Important Targets Associated with Chronic Inflammation and Oxidative Stress in Cancer Treatment

Neganova

Liu

Aleksandrova

et al. 2021

Cancers

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Chronic inflammation and oxidative stress are the interconnected pathological processes, which lead to cancer initiation and progression. The growing level of oxidative and inflammatory damage was shown to increase cancer severity and contribute to tumor spread. The overproduction of reactive oxygen species (ROS), which is associated with the reduced capacity of the endogenous cell defense mechanisms and/or metabolic imbalance, is the main contributor to oxidative stress. An abnormal level of ROS was defined as a predisposing factor for the cell transformation that could trigger pro-oncogenic signaling pathways, induce changes in gene expression, and facilitate accumulation of mutations, DNA damage, and genomic instability. Additionally, the activation of transcription factors caused by a prolonged oxidative stress, including NF-κB, p53, HIF1α, etc., leads to the expression of several genes responsible for inflammation. The resulting hyperactivation of inflammatory mediators, including TNFα, TGF-β, interleukins, and prostaglandins can contribute to the development of neoplasia. Pro-inflammatory cytokines were shown to trigger adaptive reactions and the acquisition of resistance by tumor cells to apoptosis, while promoting proliferation, invasion, and angiogenesis. Moreover, the chronic inflammatory response leads to the excessive production of free radicals, which further aggravate the initiated reactions. This review summarizes the recent data and progress in the discovery of mechanisms that associate oxidative stress and chronic inflammation with cancer onset and metastasis. In addition, the review provides insights for the development of therapeutic approaches and the discovery of natural substances that will be able to simultaneously inhibit several key oncological and inflammation-related targets.

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The Potential of Flavonoids and Tannins from Medicinal Plants as Anticancer Agents

Cited by 35 publications

References 137 publications

Natural Compounds for Wood Protection against Fungi—A Review

Natural Compounds for Wood Protection against Fungi—A Review

Ethnopharmacology and Antioxidant Activity Studies of Woody Liana Original Wallacea

Therapeutic Influence on Important Targets Associated with Chronic Inflammation and Oxidative Stress in Cancer Treatment

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