The potential of geraniol to reduce cytotoxic and genotoxic effects of MNNG in plant and human lymphocyte test-systems

Gateva, Svetla; Jovtchev, Gabriele; Stankov, Alexander; Georgieva, Almira; Dobreva, Ana; Mileva, Milka

doi:10.1016/j.sajb.2019.03.005

Cited by 13 publications

(14 citation statements)

References 52 publications

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“…Although geraniol was the active agent used in smaller amounts in the formulations, the presence of this compound could help to explain the low genotoxicity observed. Gateva et al reported that the use of geraniol at low concentrations could have a genoprotective effect, reducing the cytotoxicity and genotoxicity caused by the alkylating agent N -methyl- N ′-nitro- N -nitrosoguanidine, which is often used to study lesions produced in DNA, as well as possible repair mechanisms.…”

Section: Resultsmentioning

confidence: 99%

Cellulose Hydrogels Containing Geraniol and Icaridin Encapsulated in Zein Nanoparticles for Arbovirus Control

Rogério

Abrantes

Oliveira

et al. 2022

ACS Appl. Bio Mater.

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The most important arboviruses are those that cause dengue, yellow fever, chikungunya, and Zika, for which the main vector is the Aedes aegypti mosquito. The use of repellents is an important way to combat mosquito-borne pathogens. In this work, a safe method of protection employing a repellent was developed based on a slow release system composed of zein nanoparticles containing the active agents icaridin and geraniol incorporated in a cellulose gel matrix. Analyses were performed to characterize the nanoparticles and the gel formulation. The nanoparticles containing the repellents presented a hydrodynamic diameter of 229 ± 9 nm, polydispersity index of 0.38 ± 0.10, and zeta potential of +29.4 ± 0.8 mV. The efficiencies of encapsulation in the zein nanoparticles exceeded 85% for icaridin and 98% for geraniol. Rheological characterization of the gels containing nanoparticles and repellents showed that the viscoelastic characteristic of hydroxypropylmethylcellulose gel was preserved. Release tests demonstrated that the use of nanoparticles in combination with the gel matrix led to improved performance of the formulations. Atomic force microscopy analyses enabled visualization of the gel network containing the nanoparticles. Cytotoxicity assays using 3T3 and HaCaT cell cultures showed low toxicity profiles for the active agents and the nanoparticles. The results demonstrated the potential of these repellent systems to provide prolonged protection while decreasing toxicity.

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Section: Resultsmentioning

confidence: 99%

Cellulose Hydrogels Containing Geraniol and Icaridin Encapsulated in Zein Nanoparticles for Arbovirus Control

Rogério

Abrantes

Oliveira

et al. 2022

ACS Appl. Bio Mater.

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“…The chemical constituents identified in higher quantities in our previous study [12] included geraniol and nerol. They belong to the group of monoterpene oxygenated derivatives, and manifest cytotoxic activity in a concentration-dependent manner in various cell types [48,49]. Geraniol treatment at concentrations of 10-100 µg/mL causes no high cytotoxicity in human lymphocytes, whereas it does not inhibit cell viability in barley cells [49].…”

Section: Discussionmentioning

confidence: 99%

Genotoxic and Anti-Genotoxic Potential of Hydrosols from Water–Steam Distillation of Oil-Bearing Roses Rosa centifolia L. and Rosa gallica L. from Bulgaria

Gateva,

Jovtchev,

Angelova

et al. 2024

Pharmaceuticals

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Rosa centifolia L. and Rosa gallica L. (Rosaceae) are grown as raw materials for valuable essential oils and hydrosols. There are scarce data about the biological activities and the genoprotective potential of the hydrosols of these roses. The aim of the study was to provide information on their cytotoxic/genotoxic activity and anti-cytotoxic/anti-genotoxic capacity against mutagenic N-methyl-N′-nitro-N-nitrosoguanidine (MNNG). The evaluation was performed using classical tests for chromosomal aberrations and micronuclei in the higher plant Hordeum vulgare and human lymphocyte test systems. The experimental schemes included combined hydrosol and mutagen treatment. Both hydrosols (6, 14, 20%) had no cytotoxic effect on barley and showed low genotoxicity in both test systems as the injuries were enhanced to a lesser extent compared to the controls. Lymphocytes were more susceptible than H. vulgare. Under the conditions of combined treatment, it was found that the two hydrosols possessed good anti-cytotoxic and anti-genotoxic potential against MNNG. Both rose products exerted genoprotective potential to a similar extent, decreasing the frequencies of aberrations in chromosomes and micronuclei to a significant degree in both types of cells when non-toxic concentrations of hydrosols were applied before MNNG. This was performed both with and without any inter-treatment time. The observed cytoprotective/genoprotective potential suggests that these hydrosols are promising for further application in phytotherapy and medicine.

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“…As it can be seen, they are a mixture of many biologically active substances that belong to the groups of oxidised monoterpenes, benzoid components, oxidised aliphatics and pentacyclic terpenoids. In the literature, there is much information about the biological activities of the components included in this composition [ 3 , 11 , 12 , 13 , 14 , 16 , 17 , 18 ]. The most important ingredients in rose oils are nerol, citronellal, citronellol, geraniol, eugenol and others.…”

Section: Discussionmentioning

confidence: 99%

“…The data about their cytotoxic/anticytotoxic, mutagenic/antimutagenic and genotoxic/antigenotoxic potentials are of particular importance for the protection of the cell genome from damage induced by various factors. The results reported showed that these oils are cytotoxically and genotoxically safe products [ 15 , 16 , 17 ].…”

Section: Introductionmentioning

confidence: 99%

Antiviral Activity of Rosa damascena Mill. and Rosa alba L. Essential Oils against the Multiplication of Herpes Simplex Virus Type 1 Strains Sensitive and Resistant to Acyclovir

Vilhelmova-Ilieva

Dobreva²,

Doynovska

et al. 2021

Biology

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Background: The specific chemotherapeutics against herpes simplex virus type 1 (HSV) are nucleoside analogues such as acyclovir (ACV), but the most important problem is the formation of resistant mutants. The search for new therapeutic alternatives leads us to the purpose of investigating the effects of Rosa damascena Mill. and Rosa alba L. essential oils on the viral reproduction of susceptible (Victoria) and acyclovir-resistant (R-100) strains of HSV-1 replication in vitro, individually and in combination with acyclovir. Methods: Cytopathic effect inhibition test was used for assessment of antiviral activity of the oils, and the three-dimensional model of Prichard and Shipman was applied to evaluate the combined effect of oils with ACV on HSV-1 replication. Results: Both oils do not affect the replication of viral strains; they are able to influence only viral adsorption and extracellular virions and protect healthy cells from subsequent infection. In combination with lower doses of acyclovir, both oils demonstrate a significant synergistic effect on the replication of HSV-1, which is more contagious than the Victoria strain. Conclusions: The nonspecific mechanism of the reduction in viral reproduction caused by rose oils and the synergistic effect of their co-administration with the lower doses of specific inhibitor ACV makes them suitable therapeutics for overcoming viral resistance to HSV-1 infections.

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The potential of geraniol to reduce cytotoxic and genotoxic effects of MNNG in plant and human lymphocyte test-systems

Cited by 13 publications

References 52 publications

Cellulose Hydrogels Containing Geraniol and Icaridin Encapsulated in Zein Nanoparticles for Arbovirus Control

Cellulose Hydrogels Containing Geraniol and Icaridin Encapsulated in Zein Nanoparticles for Arbovirus Control

Genotoxic and Anti-Genotoxic Potential of Hydrosols from Water–Steam Distillation of Oil-Bearing Roses Rosa centifolia L. and Rosa gallica L. from Bulgaria

Antiviral Activity of Rosa damascena Mill. and Rosa alba L. Essential Oils against the Multiplication of Herpes Simplex Virus Type 1 Strains Sensitive and Resistant to Acyclovir

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