The potential of herbal drugs to treat heart failure: The roles of Sirt1/AMPK

Zhang, Tao; Xu, Lei; Guo, Xiaowei; Tao, Honglin; Liu, Yue; Liu, Xianfeng; Zhang, Yi; Meng, Xianli

doi:10.1016/j.jpha.2023.09.001

Cited by 9 publications

(5 citation statements)

References 221 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Most compounds from Coicis semen primarily impact mitochondrial function rather than mitochondrial biogenesis or structure ( Table 2 ; Figure 3 ). Berberine, a bioactive component of Coicis semen, may increase the Klotho/SIRT1 signaling pathway to alleviate mitochondrial dysfunction and cardiac senescence ( Zhang T. et al, 2023 ). Klotho is an anti-aging protein that effectively reduces oxidative stress, inhibits apoptosis, and preserves mitochondrial function ( Li et al, 2022 ; Donate-Correa et al, 2023 ).…”

Section: The Potential Impact Of Yyfz On Mitochondria-er Interactionsmentioning

confidence: 99%

Cardiovascular protection of YiyiFuzi powder and the potential mechanisms through modulating mitochondria-endoplasmic reticulum interactions

Ding,

Ji,

Wang

et al. 2024

Front. Pharmacol.

View full text Add to dashboard Cite

Cardiovascular diseases (CVD) remain the leading cause of death worldwide and represent a major public health challenge. YiyiFuzi Powder (YYFZ), composed of Coicis semen and Fuzi, is a classical traditional Chinese medicine prescription from the Synopsis of Golden Chamber dating back to the Han Dynasty. Historically, YYFZ has been used to treat various CVD, rooted in Chinese therapeutic principles. Network pharmacology analysis indicated that YYFZ may exhibit direct or indirect effects on mitochondria-endoplasmic reticulum (ER) interactions. This review, focusing on the cardiovascular protective effects of Coicis semen and Fuzi, summarizes the potential mechanisms by which YYFZ acts on mitochondria and the ER. The underlying mechanisms are associated with regulating cardiovascular risk factors (such as blood lipids and glucose), impacting mitochondrial structure and function, modulating ER stress, inhibiting oxidative stress, suppressing inflammatory responses, regulating cellular apoptosis, and maintaining calcium ion balance. The involved pathways include, but were not limited to, upregulating the IGF-1/PI3K/AKT, cAMP/PKA, eNOS/NO/cGMP/SIRT1, SIRT1/PGC-1α, Klotho/SIRT1, OXPHOS/ATP, PPARα/PGC-1α/SIRT3, AMPK/JNK, PTEN/PI3K/AKT, β2-AR/PI3K/AKT, and modified Q cycle signaling pathways. Meanwhile, the MCU, NF-κB, and JAK/STAT signaling pathways were downregulated. The PERK/eIF2α/ATF4/CHOP, PERK/SREBP-1c/FAS, IRE1, PINK1-dependent mitophagy, and AMPK/mTOR signaling pathways were bidirectionally regulated. High-quality experimental studies are needed to further elucidate the underlying mechanisms of YYFZ in CVD treatment.

show abstract

Section: The Potential Impact Of Yyfz On Mitochondria-er Interactionsmentioning

confidence: 99%

Cardiovascular protection of YiyiFuzi powder and the potential mechanisms through modulating mitochondria-endoplasmic reticulum interactions

Ding,

Ji,

Wang

et al. 2024

Front. Pharmacol.

View full text Add to dashboard Cite

show abstract

“…4−6 The calcium imbalance, inflammatory response, and oxidative stress that occur after cardiac I/R injury gradually channel blockers, and diuretics. 8,9 These treatment measures can reduce myocardial oxygen consumption, improve heart function to prolong lifespan, but they have side effects such as edema, hyperkalemia, fatigue, and dizziness, which affect the quality of life of patients. 8 Due to the complexity of the pathogenesis of cardiovascular and cerebrovascular diseases, the existing single treatment methods often fail to meet clinical needs.…”

Section: Introductionmentioning

confidence: 99%

“…After the occurrence of cardiac ischemia/reperfusion (I/R) injury, dendritic spine loss leads to the appearance of anxiety, depression, insomnia, and even cognitive impairment. − The calcium imbalance, inflammatory response, and oxidative stress that occur after cardiac I/R injury gradually disrupt the blood–brain barrier (BBB), exacerbating damage to the brain. , Ischemic stroke (IS) is one of the most serious complications. Currently, anti-I/R injury often uses angiotensin-converting enzyme inhibitors, beta-blockers, calcium channel blockers, and diuretics. , These treatment measures can reduce myocardial oxygen consumption, improve heart function to prolong lifespan, but they have side effects such as edema, hyperkalemia, fatigue, and dizziness, which affect the quality of life of patients . Due to the complexity of the pathogenesis of cardiovascular and cerebrovascular diseases, the existing single treatment methods often fail to meet clinical needs.…”

Section: Introductionmentioning

confidence: 99%

“… 8 , 9 These treatment measures can reduce myocardial oxygen consumption, improve heart function to prolong lifespan, but they have side effects such as edema, hyperkalemia, fatigue, and dizziness, which affect the quality of life of patients. 8 Due to the complexity of the pathogenesis of cardiovascular and cerebrovascular diseases, the existing single treatment methods often fail to meet clinical needs. Therefore, seeking comprehensive treatment methods for brain damage caused by cardiac I/R injury (BD-CI/R) has become a new research focus.…”

Section: Introductionmentioning

confidence: 99%

“…Studies have confirmed that natural ingredients such as flavonoids like quercetin, terpenes like catalpol, polyphenols like resveratrol, saponins like dioscin, derived from herbs, can improve I/R injury through antioxidative, anti-inflammatory, antiapoptotic, and regulation of energy metabolism pathways. 8 , 10 − 12 This indicates that natural products have the comprehensive therapeutic advantage of multiple components, targets, and mechanisms of action. Danhong Injection (DHI) is composed of Salviae Miltiorrhizae Radix et Rhizoma, known as Danshen in Chinese (DS), and Carthami Flos, known as Honghua in Chinese (HH).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Investigating the Mechanistic of Danhong Injection in Brain Damage Caused by Cardiac I/R Injury via Bioinformatics, Computer Simulation, and Experimental Validation

Wang,

Guo,

Zhou

et al. 2024

ACS Omega

View full text Add to dashboard Cite

Objective: Cardiac ischemia-reperfusion (I/R) injury has negative effects on the brain and can even lead to the occurrence of ischemic stroke. Clinical evidence shows that Danhong injection (DHI) protects the heart and brain following ischemic events. This study investigated the mechanisms and key active compounds underlying the therapeutic effect of DHI against brain damage induced by cardiac I/R injury. Methods: The gene expression omnibus database provided GSE66360 and GSE22255 data sets. The R programming language was used to identify the common differentially expressed genes (cDEGs). Gene ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analysis were performed, and protein−protein interaction network was constructed. Active compounds of DHI were collected from the Traditional Chinese Medicine Systems Pharmacology database. Molecular docking and molecular dynamics simulations were performed. The MMPBSA method was used to calculate the bindingfree energy. The pkCSM server and DruLiTo software were used for Absorption, Distribution, metabolism, excretion, and toxicity (ADMET) analysis and drug-likeness analysis. Finally, in vitro experiments were conducted to validate the results. Results: A total of 27 cDEGs had been identified. The PPI and enrichment results indicated that TNF-α was considered to be the core target. A total of 80 active compounds were retrieved. The molecular docking results indicated that tanshinone I (TSI), tanshinone IIA (TSIIA), and hydroxyl safflower yellow A (HSYA) were selected as core active compounds. Molecular dynamics verification revealed that the conformations were relatively stable without significant fluctuations. MMPBSA analysis revealed that the binding energies of TSI, TSIIA, and HSYA with TNF-α were −36.01, −21.71, and −14.80 kcal/mol, respectively. LEU57 residue of TNF-α has the highest contribution. TSI and TSIIA passed both the ADMET analysis and drug-likeness screening, whereas HSYA did not. Experimental verification confirmed that DHI and TSIIA reduced the expression of TNF-α, NLRP3, and IL-1β in the injured H9C2 and rat brain microvascular endothelial cells. Conclusion: TNF-α can be considered to be a key target for BD-CI/R. TSIIA in DHI exerts a significant inhibitory effect on the inflammatory damage of BD-CI/R, providing new insights for future drug development.

show abstract

The role of quercetin in ameliorating bleomycin-induced pulmonary fibrosis: insights into autophagy and the SIRT1/AMPK signaling pathway

Li,

Jiao,

et al. 2024

Mol Biol Rep

View full text Add to dashboard Cite

The potential of herbal drugs to treat heart failure: The roles of Sirt1/AMPK

Cited by 9 publications

References 221 publications

Cardiovascular protection of YiyiFuzi powder and the potential mechanisms through modulating mitochondria-endoplasmic reticulum interactions

Cardiovascular protection of YiyiFuzi powder and the potential mechanisms through modulating mitochondria-endoplasmic reticulum interactions

Investigating the Mechanistic of Danhong Injection in Brain Damage Caused by Cardiac I/R Injury via Bioinformatics, Computer Simulation, and Experimental Validation

The role of quercetin in ameliorating bleomycin-induced pulmonary fibrosis: insights into autophagy and the SIRT1/AMPK signaling pathway

Contact Info

Product

Resources

About