The Potential of Magnetic Nanoparticles for Diagnosis and Treatment of Cancer Based on Body Magnetic Field and Organ-on-the-Chip

Abstract

Cancer is an abnormal cell growth which tends to proliferate in an uncontrolled way and, in some cases, leads to metastasis. If cancer is left untreated, it can immediately cause death. The use of magnetic nanoparticles (MNPs) as a drug delivery system will enable drugs to target tissues and cell types precisely. This study describes usual strategies and consideration for the synthesis of MNPs and incorporates payload drug on MNPs. They have advantages such as visual targeting and delivering which will be discussed in this review. In addition, we considered body magnetic field to make drug delivery process more effective and safer by the application of MNPs and tumor-on-chip.

Nanotechnology‐Based Strategies to Evaluate and Counteract Cancer Metastasis and Neoangiogenesis

“…Using MNPs in cancer therapy provides the possibility of drug accumulation into previously determined area, since MNPs can be manipulated by using static magnetic fields; moreover, they are also used for local hyperthermia since they can generate heating via an alternating magnetic field. [ 171 ]…”

Magnetic nanoparticles in microfluidic and sensing: From transport to detection

“…MNPs are nontoxic and well tolerated by living organisms, therefore, appropriate for bioapplications [64]. They can be synthesized in nanometer range by the different process making them ideal for probing and manipulating biomolecules with minimum undesirable interactions [65]. Magnetically labeled material can be integrated into microfluidic systems to facilitate targeting, imaging, detecting, delivering, and therapy simultaneously.…”

Dual Loading of Doxorubicin and Magnetic Iron Oxide into PLA‐TPGS Nanoparticles: Design, in vitro Drug Release Kinetics, and Biological Effects on Cancer Cells

“…In addition to chemotherapy agents, magnetic iron oxide nanoparticles (MIONs) have attracted much attention in cancer treatment and diagnosis thanks to their natural magnetic properties [15] . In cancer treatment, many functions of MIONs were exploited such as (i) drug carrier; [16] (ii) concentrating drug in tumor by external magnetic fiel; [17] (iii) hyperthermia effect [18] . For more details, magnetic iron oxide nanoparticles are widely used in drug delivery systems due to their good adsorption properties.…”