The Potential of Molecular Diagnostics in Routine Dermatology

Kupsch, Christiane; Gräser, Yvonne

doi:10.1007/978-3-030-67421-2_16

Cited by 1 publication

(4 citation statements)

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“…6 Common target sequences for PCR include the ribosomal internal transcribed spacer (ITS) and translation elongation factor 1α (EF1α). 6,7 Conserved sequences (i.e. ITS) are ideal PCR targets for broad dermatophyte detection; however, greater specificity is achieved when less conserved sequences, such as EF1α, are targeted.…”

Section: Polymerase Chain Reaction (Pcr) Is a Sensitive Technique Usedmentioning

confidence: 99%

“…Polymerase chain reaction (PCR) is a sensitive technique used for dermatophyte identification at both genus and species levels 6 . Common target sequences for PCR include the ribosomal internal transcribed spacer (ITS) and translation elongation factor 1‐α (EF1‐α) 6,7 . Conserved sequences (i.e.…”

Section: Diagnosismentioning

confidence: 99%

“…This technique relies on in silico matching of dermatophyte mass spectra to spectra maintained in publicly available or in-house developed databases. 6 Previously, inabilities to differentiate Trichophyton spp. have been reported; however, updated databases allow for increased specificity.…”

Section: Polymerase Chain Reaction (Pcr) Is a Sensitive Technique Usedmentioning

confidence: 99%

“…The use of matrix‐assisted laser desorption ionization: time of flight mass spectrometry (MALDI‐TOF/MS) has also become more popular for dermatophyte identification. This technique relies on in silico matching of dermatophyte mass spectra to spectra maintained in publicly available or in‐house developed databases 6 . Previously, inabilities to differentiate Trichophyton spp .…”

Section: Diagnosismentioning

confidence: 99%

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Tinea capitis: An update

Gupta

Friedlander

Simkovich

2022

Pediatric Dermatology

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Tinea capitis is an important superficial infection and affects children globally. A literature review was conducted to identify recent findings and the current understanding of this fungal infection. Here, we highlight updates on important aspects of tinea capitis including advances in dermatophyte detection and diagnosis and comparing these new methods to more traditional techniques. Additionally, aspects of treating tinea capitis are discussed, including the importance of mycological confirmation and current means of treatment, and the treatment of asymptomatic carriers are reviewed. This review also examines the subject of laboratory monitoring of patients undergoing treatment with systemic antifungals; we discuss the opinions of prominent researchers and currently accepted guidelines. Lastly, we provide answers to several common questions that practitioners may encounter when treating a child with tinea capitis.

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Section: Polymerase Chain Reaction (Pcr) Is a Sensitive Technique Usedmentioning

confidence: 99%

Section: Diagnosismentioning

confidence: 99%

Section: Polymerase Chain Reaction (Pcr) Is a Sensitive Technique Usedmentioning

confidence: 99%

Section: Diagnosismentioning

confidence: 99%

See 2 more Smart Citations