The potential of NMDA antagonists for stroke treatment

Scatton, B.; Carter, C; Poignet, H.; Duval, D.; Bénavidès, J.

doi:10.1016/0924-977x(91)90504-n

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Excitatory Amino Acid-induced Damage1

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1994

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“…), increase the release of EAA, which may lead to neuronal overexcitation. This may initiate a complex cascade of deleterious biochemical events, starting with massive influx of calcium into the cell via NMDA-receptor-gated channels, and resulting in neurotoxic destruction of the nerve cell (Mayer et al 1989;Scatton et al 1991).…”

Section: Excitatory Amino Acid-induced Damagementioning

confidence: 99%

Neuropathobiology of Senile Dementia and Mechanism of Action of Nootropic Drugs

Benešová

1994

Drugs & Aging

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Recent advances in neuroscience and molecular neurochemistry have substantially increased the knowledge of the neuropathobiology of senile dementia and Alzheimer's disease. On the basis of various hypotheses concerning degenerative processes in aging brains, new therapeutic strategies have been developed, including nootropic drugs with different mechanisms of action and heterogenous chemical structures. Mutual relationships exist between neuroscientific research and nootropic drug development. To date, such areas of research and drug development have involved deficits of brain neurotransmission (cholinergic, monoaminergic, peptidergic), free radical-induced damage, disturbances of calcium homeostasis and excitatory amino acid function, and deposition of amyloid protein.

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Section: Excitatory Amino Acid-induced Damagementioning

confidence: 99%

Neuropathobiology of Senile Dementia and Mechanism of Action of Nootropic Drugs

Benešová

1994

Drugs & Aging

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show abstract

The potential of NMDA antagonists for stroke treatment

Cited by 1 publication

References 4 publications

Neuropathobiology of Senile Dementia and Mechanism of Action of Nootropic Drugs

Neuropathobiology of Senile Dementia and Mechanism of Action of Nootropic Drugs

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