The Potential of Parsley Polyphenols and Their Antioxidant Capacity to Help in the Treatment of Depression and Anxiety: An In Vivo Subacute Study

Abstract

Depression and anxiety are major mental health problems in all parts of the world. These illnesses are associated with a number of risk factors, including oxidative stress. Psychotropic drugs of a chemical nature have demonstrated several side effects that elevated the impact of those illnesses. Faced with this situation, natural products appear to be a promising alternative. The aim of this study was to evaluate the anxiolytic and antidepressant effects of the Petroselinum sativum polyphenols in vivo, as well as its correlated antioxidant properties in vitro. Anxiolytic activity of the extract (50 and 100 mg/kg) was evaluated using the open field and the light-dark chamber tests, while the antidepressant activity was evaluated using the forced swimming test. The antioxidant activity of the extract was evaluated by the 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical test and the FRAP (iron-reducing capacity) test. The phenolic extract showed very powerful anxiolytic and antidepressant-like effects, especially at a dose of 100 mg/kg, decreasing the depressive behavior in mice (decreased immobility time) and also the anxiolytic behavior (tendency for discovery in the center and illuminated areas) better even than those of paroxetine and bromazepam (classic drugs) concomitant with those results the extract also showed an important antioxidant capacity. These preliminary results suggest that Petroselinum sativum exhibits anxiolytic and antidepressant potential for use as a complement or independent phytomedicine to treat depression and anxiety.

Assessment of Antidepressant-like, Anxiolytic Effects and Impact on Memory of Pimpinella anisum L. Total Extract on Swiss Albino Mice

“…Clinical and pre-clinical trials have reported successful use of medications for certain plant metabolites, such as alkaloids, terpenes, flavonoids, and sterols and others [ 24 , 25 ]. Medicinal plants have also proven efficacy against depression and anxiety, reported with the use of multiple plants, such as Carum carvi polyphenols at doses of 50 and 100 mg/kg [ 26 ], Coriandrum sativum at doses of 50, 100, and 200 mg/kg [ 27 ], Origanum majorana polyphenols at doses of 50 and 100 mg/kg [ 28 ], and Petroselinum sativum at doses of 50 and 100 mg/kg [ 29 ].…”

Protective Effect of Opuntia dillenii (Ker Gawl.) Haw. Seed Oil on Gentamicin-Induced Nephrotoxicity: A Biochemical and Histological Analysis

“…A study that concerns the chemical composition of ODSO has shown that it is also rich in phenolic compounds [33]. ese compounds are well known for their antioxidants power, and they are found in many foods and beverages and involved in the prevention of several major chronic illnesses [34,35]. erefore, the nephroprotective effect of ODSO may be related to its free radical trapping effect generated by gentamicin and related to its antioxidant activities.…”

Phytochemical Screening, In Vitro and In Silico Studies of Volatile Compounds from Petroselinum crispum (Mill) Leaves Grown in Saudi Arabia

“…The chemopreventive effects of parsley leaf oil were demonstrated in a study, and the potential cancer-preventive effects were attributed mainly to the presence of Myristicin [ 30 ]. Various other P. crispum has been reported in studies [ 31 , 32 ]. Myristicin was found to be the principal constituent of PCEO.…”