The Potential of Plant Phenolics in Prevention and Therapy of Skin Disorders

Abstract

Phenolic compounds constitute a group of secondary metabolites which have important functions in plants. Besides the beneficial effects on the plant host, phenolic metabolites (polyphenols) exhibit a series of biological properties that influence the human in a health-promoting manner. Evidence suggests that people can benefit from plant phenolics obtained either by the diet or through skin application, because they can alleviate symptoms and inhibit the development of various skin disorders. Due to their natural origin and low toxicity, phenolic compounds are a promising tool in eliminating the causes and effects of skin aging, skin diseases, and skin damage, including wounds and burns. Polyphenols also act protectively and help prevent or attenuate the progression of certain skin disorders, both embarrassing minor problems (e.g., wrinkles, acne) or serious, potentially life-threatening diseases such as cancer. This paper reviews the latest reports on the potential therapy of skin disorders through treatment with phenolic compounds, considering mostly a single specific compound or a combination of compounds in a plant extract.

Potent anti-oxidant and anti-inflammatory potentials of Punica granatum leaf and flower hydromethanolic extracts in vitro

“…Previous studies on medicinal plants reviewed by (WYNN;FOUGÈRE, 2007) have indicated that some of them have good potentials as antioxidants including Ginger (Zingiber officinale), Ginkgo biloba, Grapeseed (Vitis vinifera), Green tea (Camellia sinensis), Reishi (Ganoderma lucidum), Rosemary (Rosmarinus officinale), Skullcap (Scutellaria lateriflora), Milk thistle (Silybum marianum), and Turmeric (Curcuma longa). The antioxidant potential of those plants was attributable to their content of one or more of active ingredients belong to phenolics, flavonoids and tannins (DZIAŁO et al, 2016).…”

Evaluation of Phytochemical and Antioxidant Activity of Tridax procumbens Extract

“…One of the special sources of antioxidants is plant-based natural phenolic compounds. Phenolic compounds are found to be one of the most important groups of plant secondary metabolites, due to their great participation in morphological development, physiological processes and reproduction 4 . …”

Morin Prevents Ultraviolet-B Radiation-Induced Photocarcinogenesis Through Activating Thrombospondin-1 in the Mouse Skin

“…Polyphenols and flavonoids are widely spread in plants, mainly in fruits and vegetables, contributing to their flavor and color [27]. The flavonoids constitute a large group of compounds containing a number of phenolic hydroxyl groups attached to ring structures and it possesses significant antioxidant activity [28,29].…”