The potential of platelet-rich plasma injections and stem cell therapy for penile rejuvenation

Israeli, Joseph M.; Lokeshwar, Soum D.; Efimenko, Iakov; Masterson, Thomas A.; Ramasamy, Ranjith

doi:10.1038/s41443-021-00482-z

Cited by 21 publications

(3 citation statements)

References 60 publications

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“…In the current study, there were improved IIEF‐5 scores, recovered responses to on‐demand PDE5 inhibitors, better responses to ICI testing, better‐quality pharmaco‐penile duplex (higher mean PSV and lower mean EDV) among both investigated groups. Israeli et al (2021) showed that PRP therapy rehabilitated the endothelial function and/or improved the nerve function. However, the beneficial effect obtained in the current study cannot be attributed alone to ICI therapy of PRP, but it can be due to the combined effect of both 5mg daily tadalafil and the ICI of PRP.…”

Section: Discussionmentioning

confidence: 99%

Assessment of the intracavernosal injection platelet‐rich plasma in addition to daily oral tadalafil intake in diabetic patients with erectile dysfunction non‐responding to on‐demand oral PDE5 inhibitors

et al. 2022

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This study aimed to evaluate the effectiveness of ICI of platelet‐rich plasma (PRP) in addition to daily oral tadalafil intake in diabetic erectile dysfunction (ED) patients non‐responding to PDE5 inhibitors. Overall, 48 patients complaining of ED non‐responding to on‐demand PDE5 inhibitors were allocated into 2 equal groups, diabetics and non‐diabetics that were given a daily dose of 5 mg tadalafil plus vardenafil 20 mg on demand during the study besides being subjected to 3 doses of ICI of PRP, 4 weeks apart. Responses to on‐demand PDE5 inhibitors, International index of erectile function‐5 (IIEF‐5) score, erection hardness scores (EHS) and pharmaco‐dynamic duplex studies were assessed. After PRP injections, 33% and 50% of cases were satisfied with on‐demand PDE5 inhibitors, respectively, whereas 41% and 66% of them showed improved EHS response. Compared with baseline scores, the mean IIEF‐5 scores were significantly improved after PRP therapy in the diabetic ED group (12.1 vs. 8.04, p = 0.003) as well as in the non‐diabetic ED group (14.8 vs. 10.2, p = 0.001) linked to pharmaco‐penile duplex readings. Both good and fair diabetic control exhibited significant responses to ICI therapy of PRP compared with bad controlled cases. The significant improvement included; the IIEF‐5 score increase (86.7%, 126% vs. 16.1%), improved EHS as well as penile duplex readings. Baseline HbA1C demonstrated a significant negative correlation with IIEF‐5 score before (p = 0.019) and after PRP therapy (p = 0.002) respectively. It could be concluded that ICI of PRP could be an effective therapy for treating ED patients non‐responding to on‐demand oral PDE5 treatment.

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Section: Discussionmentioning

confidence: 99%

Assessment of the intracavernosal injection platelet‐rich plasma in addition to daily oral tadalafil intake in diabetic patients with erectile dysfunction non‐responding to on‐demand oral PDE5 inhibitors

et al. 2022

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“…There are multiple centrifuges on the market, many that come with their own collection kits, that create specific volumes of PRP. 5 Importantly, volume is unrelated to the concentration of platelets or growth factors contained within the PRP. Heterogeneity in platelet and growth factor concentration is a substantial problem and plagues all PRP studies.…”

Section: Platelet-rich Plasma For the Treatment Of Erectilementioning

confidence: 99%

Platelet-rich Plasma for the Treatment of Erectile Dysfunction: A Prospective, Randomized, Double-blind, Placebo-controlled Clinical Trial. Reply.

Masterson,

Molina,

Ledesma

et al. 2023

Journal of Urology

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“…Механизм действия тСК основан на том, что стволовые клетки, введённые в кавернозное тело, дифференцируются в другие клетки, такие как гладкомышечные клетки, клетки эндотелия и нейроны. Кроме того, паракринные факторы могут стимулировать миграцию других клеток в кавернозные тела, тем самым стимулируя восстановление кавернозной ткани [44].…”

Section: анализ данных и обсуждениеunclassified

Penile rehabilitation in patients following surgical treatment of Peyronie’s disease

et al. 2023

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Peyronie's disease (PD) is an acquired disease, which is based on a violation of the wound healing process, which results in the formation of fibrous plaques in the tunica albuginea of the cavernous bodies. The prevalence of erectile dysfunction (ED) among patients with PD ranges from 22% to 54%, according to various studies. Surgical treatment remains the "gold standard" for correcting penile curvature in PD. It is important to note that the existing methods of PD surgery (techniques with shortening or lengthening of the tunica albuginea) carry the risks of developing ED or aggravating its severity. At the same time, the absence of adequate sexual rehabilitation following PD surgery is associated with a significant deterioration in functional outcomes. In view of the above, the article is aimed to systematise information on penile rehabilitation methods in patients following PD surgery, which showed that the problem remains relevant to the present day. Most existing penile rehabilitation methods are currently not sufficiently investigated, and it is therefore impossible to give clear recommendations on the use of any method. The small number of well-designed and randomised studies on this problem is noteworthy, most likely due to the relative rarity of the disease.

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The potential of platelet-rich plasma injections and stem cell therapy for penile rejuvenation

Cited by 21 publications

References 60 publications

Assessment of the intracavernosal injection platelet‐rich plasma in addition to daily oral tadalafil intake in diabetic patients with erectile dysfunction non‐responding to on‐demand oral PDE5 inhibitors

Assessment of the intracavernosal injection platelet‐rich plasma in addition to daily oral tadalafil intake in diabetic patients with erectile dysfunction non‐responding to on‐demand oral PDE5 inhibitors

Platelet-rich Plasma for the Treatment of Erectile Dysfunction: A Prospective, Randomized, Double-blind, Placebo-controlled Clinical Trial. Reply.

Penile rehabilitation in patients following surgical treatment of Peyronie’s disease

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