The Potential of Purple Waxy Corn Cob (Zea mays L.) Extract Loaded-Sericin Hydrogel for Anti-Hyperpigmentation, UV Protection and Anti-Aging Properties as Topical Product Applications

Abstract

Sericin-hydrogel formulations incorporating purple waxy corn (Zea mays L.) cob extract (PWCC) were developed as potential topical skin cosmetic products. Sericin has wound healing properties, protects against ultraviolet (UV) radiation, and exhibits anti-inflammatory, anti-oxidation, and anti-tyrosinase activities. PWCC is a rich source of anthocyanins with antioxidants, UV protective, anti-inflammatory, and collagen-enhancing activities. Six hydrogel formulations (S1–S6) were investigated for anti-melanogenesis on the B16F10 melanoma cell line and UV-protection on human keratinocytes (HaCaT) and anti-aging activities on normal human dermal fibroblasts (NHDFs). The results showed that the hydrogel formulations enhanced the anthocyanin permeation through the skin. The S4 formulation indicated the highest inhibition of tyrosinase activity and reduced the melanin pigment, increased the cell viability of the UV-induced HaCaT cells, the inhibition of collagenase and elastase, and increased the collagen type I production without cytotoxicity. Therefore, the PWCC loaded-sericin hydrogels show a high potential as a novel anti-hyperpigmentation, UV protection, and anti-aging products for topical applications.

The characteristics and biological activity enhancements of melatonin encapsulations for skin care product applications

“…Moreover, inflammatory molecules were related to collagen degradation caused to human skin aging ( Ansary et al, 2021 ) which is known melatonin can be an antioxidant agent ( Skobowiat et al, 2018 ; Slominski et al, 2014 ). Thus, melatonin can be anti-aging through reduced reactive oxygen species (ROS)-NO-mediated inflammation and stimulated collagen in dermis skin layers ( Kanpipit et al, 2023 ).…”

“…Melatonin, known for its antioxidant properties ( Skobowiat et al, 2018 ; Slominski et al, 2014 ), can potentially exhibit anti-aging effects. It achieves this by reducing reactive oxygen species (ROS)-NO-mediated inflammation and promoting collagen production in the dermal layers of the skin ( Kanpipit et al, 2023 ).…”

Melatonin/Sericin Wound Healing Patches: Implications for Melanoma Therapy

“…The most promising formulation using the purple waxy corn cob (Zea mays L.) extract demonstrated the highest tyrosinase activity inhibition, melanin pigment reduction, collagenase/elastase inhibition, collagen type I production, and elevation of cell viability. Thus, the purple waxy corn cob extract-loaded sericin hydrogel as a topical agent indicates a great potential in anti-aging products [148]. Namely, naringenin microemulsion-loaded sericin gel showed an inhibition of UVR-induced photoaging and increased free radical scavenging.…”

“…UV light up-regulates the nuclear factor kappa B (NF-κB) and releases pro-inflammatory cytokines, with a simultaneous increased generation of ROS/RNS. Next, free Thus, the purple waxy corn cob extract-loaded sericin hydrogel as a topical agent indicates a great potential in anti-aging products [148]. Namely, naringenin microemulsionloaded sericin gel showed an inhibition of UVR-induced photoaging and increased free radical scavenging.…”

“…The recent inventions using sericin in anti-aging treatments include extract loadedsericin hydrogel as a topical agent [148], naringenin microemulsion-loaded sericin gel [149], and gold silk sericin/niacinamide/signaline complex [150]. Extract-loaded sericin hydrogels in six formulations were examined for anti-melanogenesis on the B16F10 melanoma cell line, UVR-preventive properties of human keratinocytes (HaCaT), and anti-aging ef-fectiveness on normal human dermal fibroblasts.…”