The potential of South African plants against Mycobacterium infections

McGaw, Lyndy Joy; Lall, Namrita; Meyer, J.J.M.; Eloff, Jacobus Nicolaas

doi:10.1016/j.jep.2008.08.022

Cited by 132 publications

(115 citation statements)

References 99 publications

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“…Adicionalmente, la creciente tendencia hacia el uso de compuestos de origen natural en diversos campos industriales así como los usos de las plantas en medicina tradicional, ha orientado la sospecha de la utilidad de los AEs y EVs en el manejo de la TB (Mohamad et al, 2011;McGaw et al, 2008;Baquero et al, 2007 (Pauli y Schilcher, 2009). Colombia, considerado como un país megadiverso, se ubica como la cuarta nación en biodiversidad a nivel mundial y por grupo taxonómico como el segundo en biodiversidad a nivel de plantas con 41.000 especies reportadas, lo que refleja su riqueza en fuentes naturales utilizables en la búsqueda de nuevos fitofármacos (Romero et al, 2008 Se han documentado lesiones compatibles con la enfermedad de Pott, caracterizada por las deformidades óseas a nivel de la columna vertebral; en momias egipcias y recientemente en momias peruanas y chilenas que datan del periodo precolombino (Daniel, 2006;Arriaza et al, 1995).…”

Section: Identificación Y Planteamiento Del Problemaunclassified

Search for synthetic and natural substances with in vitro bioactivity against Mycobacterium tuberculosis. Part I

Moreno¹,

Ribón²

2017

JOSHA

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Section: Identificación Y Planteamiento Del Problemaunclassified

Search for synthetic and natural substances with in vitro bioactivity against Mycobacterium tuberculosis. Part I

Moreno¹,

Ribón²

2017

JOSHA

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“…Tuberculosis is a leading cause of mortality worldwide, infecting about nine million people and killing about two million people annually [5]. The new infections and reactivation of latent tuberculosis is rising mainly in individuals with compromised immune systems, such as cases of HIV-positive individuals [6].…”

Section: Tuberculosis Is Caused By Mycobacterium Tuberculosis (Mbt) Amentioning

confidence: 99%

Performance Evaluation of Bidding-Based Multi-Agent Scheduling Algorithms for Manufacturing Systems

Gordillo¹,

Giret

2014

Machines

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Abstract:The potential bioactivity of dietary and medicinal endemic Helichrysum plants from Madeira Archipelago was explored, for the first time, in order to supply new information for the general consumer. In vitro antioxidant properties were investigated using DPPH, ABTS•+ , FRAP and β-Carotene assays, and the total phenolic content (TPC) and total flavonoid content (TFC) were also determined. Although the results generally showed a large variation among the three analyzed plants, the methanolic extracts showed the highest antioxidant capacity. Exception is made for H. devium n-hexane extract that showed good radical scavenger capacity associated to compounds with good reducing properties. In the Artemia salina toxicity assay and antimycobaterial activity, H. devium was the most potent plant with the lowest LD50 at 216.7 ± 10.4 and MIC ≤ 50 μg·mL 714(Principal Component Analysis-PCA) showed close interdependence between the ABTS, TPC and TFC methods and allowed to group H. devium samples.

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“…It is the leading cause of death worldwide from a single pathogen, claiming more lives than AIDS, malaria, diarrhea, leprosy, and all other tropical diseases combined [2]. TB is believed to be largely a disease of poverty, with the highest incidences occurring in Asia and Africa [3]. The increase in TB incidence in Africa is strongly associated with the prevalence of HIV infection among TB patients, exceeding 60% in South Africa, Botswana, Zambia, and Zimbabwe [4].…”

Section: Introductionmentioning

confidence: 99%

The Effect of Selected Combretum Species from Zimbabwe on the Growth and Drug Efflux Systems of Mycobacterium aurum and Mycobacterium smegmatis

Magwenzi

Nyakunu²,

Mukanganyama³

2011

JMBT

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Treatment of tuberculosis has become a challenge due to the rapid increase of multidrug and extensive drug resistant Mycobacterium tuberculosis. Medicinal plants might represent a possible source for new potent antibacterials to which pathogen strains are not resistant. In this study, five Combretum plant species-Combretum imberbe, Combretum zeyheri, Combretum hereroense, Combretum elaeagnoides and Combretum platypetalum used in traditional medicine were exposed to susceptibility tests to determine the effects of drug accumulation in avirulent M. smegmatis and M. aurum. The MIC values of the potent plant species was then determined. Using the agar disc diffusion assay, it was found out that the only the ethanolic extract from Combretum imberbe was active on M. smegmatis and it had an MIC of 125 µg/ml in the broth microdilution assay. However, using Sabouraud dextrose broth, Combretum platypetalum was found to have antimycobacterial effects which were not detected when using the agar disc diffusion assay. MIC of 63 and 125 µg/ml and MBCs of 250 and 500 µg/ml were obtained for C. platypetalum for M. smegmatis and M. aurum respectively. C. imberbe extract gave an MIC of 125 µg/ml but did not produce MBCs suggesting that it is bacteriostatic and not bactericidal. Drug accumulation transport assays were performed on C. imberbe, C. hereroense and C. platypetalum and results show that extracts from two plants are efflux pump inhibitors. Determination of the IC50 for the transport process was as conducted on Combretum imberbe using CCCP as the standard inhibitor. Both plants extract in addition to C. hereroense maybe potential sources for leads for efflux pump inhibitor in mycobacteria.

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The potential of South African plants against Mycobacterium infections

Cited by 132 publications

References 99 publications

Search for synthetic and natural substances with in vitro bioactivity against Mycobacterium tuberculosis. Part I

Search for synthetic and natural substances with in vitro bioactivity against Mycobacterium tuberculosis. Part I

Performance Evaluation of Bidding-Based Multi-Agent Scheduling Algorithms for Manufacturing Systems

The Effect of Selected Combretum Species from Zimbabwe on the Growth and Drug Efflux Systems of Mycobacterium aurum and Mycobacterium smegmatis

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