The potential of tear proteomics for diagnosis and management of orbital inflammatory disorders including Graves’ ophthalmopathy

Khazaei, Hadi; Khazaei, Danesh; Verma, Rohan; Ng, John D.; Wilmarth, Phillip A.; David, Larry L.; Rosenbaum, James T.

doi:10.1016/j.exer.2021.108813

Cited by 6 publications

(5 citation statements)

References 73 publications

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“…Although further research is needed, increased evidence suggests a potential role for tears as a source of biomarkers, highlighting a potential role as a diagnostic and clinical management tool [152]. Overall, these findings point to a potential role for tears as a biomarker fluid which could shape the future management of TED.…”

Section: Implications For Treatmentmentioning

confidence: 84%

Orbital Inflammation in Thyroid Eye Disease: Stress Responses and Their Implications

Aoun,

Danielova Gueorguieva,

2024

Stresses

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Thyroid Eye Disease (TED) is a debilitating autoimmune condition characterized by significant inflammation of orbital tissues, including the extraocular muscles and adipose tissues. The pathological mechanisms underlying this inflammation involve a complex interplay of stress responses at the cellular and molecular level. This review aims to critically evaluate and synthesize existing literature on the mechanisms of orbital inflammation in TED. We discuss the role of autoantibodies, cytokines, and reactive oxygen species (ROS) in the initiation and propagation of the inflammatory process. Additionally, we explore how stress responses triggered by these elements affect the integrity of orbital tissues and contribute to its remodeling. Our review underscores the need for continued research in this field, which may pave the way for novel therapeutic strategies for TED.

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Section: Implications For Treatmentmentioning

confidence: 84%

Orbital Inflammation in Thyroid Eye Disease: Stress Responses and Their Implications

Aoun,

Danielova Gueorguieva,

2024

Stresses

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“…Tear fluid represents a promising sample type for proteomics analyses. Several studies using tear fluid have provided new insights into common ocular surface and corneal diseases, such as dry eye disease, , Sjogren’s syndrome, keratoconus, and inflammatory orbital disorders . Due to the high accessibility of tear fluid, tear proteomics represents a promising tool for molecular characterization of ocular surface disease that could lead to personalized therapies and the monitoring of therapeutic response.…”

Section: Tear Proteomicsmentioning

confidence: 99%

“…Several studies using tear fluid have provided new insights into common ocular surface and corneal diseases, such as dry eye disease, 94 , 95 Sjogren’s syndrome, 31 keratoconus, 96 and inflammatory orbital disorders. 97 Due to the high accessibility of tear fluid, tear proteomics represents a promising tool for molecular characterization of ocular surface disease that could lead to personalized therapies and the monitoring of therapeutic response. The low volume of only a few microliters represents an important challenge in tear proteomics studies, and new methods are continuously developing.…”

Section: Tear Proteomicsmentioning

confidence: 99%

Liquid Biopsy Proteomics in Ophthalmology

Wolf,

Franco,

Yip

et al. 2024

J. Proteome Res.

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Minimally invasive liquid biopsies from the eye capture locally enriched fluids that contain thousands of proteins from highly specialized ocular cell types, presenting a promising alternative to solid tissue biopsies. The advantages of liquid biopsies include sampling the eye without causing irreversible functional damage, potentially better reflecting tissue heterogeneity, collecting samples in an outpatient setting, monitoring therapeutic response with sequential sampling, and even allowing examination of disease mechanisms at the cell level in living humans, an approach that we refer to as TEMPO (Tracing Expression of Multiple Protein Origins). Liquid biopsy proteomics has the potential to transform molecular diagnostics and prognostics and to assess disease mechanisms and personalized therapeutic strategies in individual patients. This review addresses opportunities, challenges, and future directions of high-resolution liquid biopsy proteomics in ophthalmology, with particular emphasis on the large-scale collection of high-quality samples, cutting edge proteomics technology, and artificial intelligence-supported data analysis.

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“…Nevertheless, the potential significance of tear biomarkers should not be undervalued. As a non-invasive technique, tear sampling endows better advantage in providing longitudinal sampling results, which aligns well with the disease progress ( 48 ). Although specific tear biomarkers for treatment response prediction have not yet been discovered, some studies have attempted to compare tear biomarkers with CAS changes before and after treatment, suggesting its promising correlation with orbital inflammation and providing evidence for its potential application in predicting treatment response.…”

Section: Body Fluid Biomarkersmentioning

confidence: 99%

Predictive markers for anti-inflammatory treatment response in thyroid eye disease

Zhang,

Fan,

et al. 2023

Front. Endocrinol.

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Anti-inflammatory treatment is the primary and vital therapeutic approach for active, moderate-to-severe thyroid eye disease (TED). Accurate pretreatment prediction of treatment response is of paramount importance for the prognosis of patients. However, relying solely on the clinical activity score asa determinant of activity has led to unsatisfactory treatment outcomes. In recent years, significant advancements have been made in identifying predictive markers for anti-inflammatory treatment response in TED, clinical markers, body fluid biomarkers and imaging biomarkers. Several clinical studies have developed prediction models based on these markers. However, there is still a lack of comprehensive elucidation or comparison between the different markers. Therefore, this review aims to provide a detailed analysis of the definition, characteristics, and application of predictive markers for anti-inflammatory treatment response in TED. Through detailed literature search, 26 articles applying anti-inflammatory treatment effect prediction with a total of 1948 TED patients were used for analysis and discussion. By gaining a better understanding of the current research on predictive markers, we can accelerate and guide the exploration of treatment prediction strategies, leading us towards an era of precise therapy for TED.

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The potential of tear proteomics for diagnosis and management of orbital inflammatory disorders including Graves’ ophthalmopathy

Cited by 6 publications

References 73 publications

Orbital Inflammation in Thyroid Eye Disease: Stress Responses and Their Implications

Orbital Inflammation in Thyroid Eye Disease: Stress Responses and Their Implications

Liquid Biopsy Proteomics in Ophthalmology

Predictive markers for anti-inflammatory treatment response in thyroid eye disease

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