2021
DOI: 10.34172/apb.2023.016
|View full text |Cite
|
Sign up to set email alerts
|

The Potential of Vouacapanes from Pterodon Emarginatus Vogel against COVID-19 Cytokine Storm

Abstract: Purpose: The emergence of the COVID-19 pandemic has led to the search for potential therapeutic responses for various aspects of this disease. Fruits of Pterodon emarginatus Vogel (Fabaceae), sucupira, have been used in Brazilian traditional medicine because of their anti-inflammatory properties, which have been proven in vivo, in vitro, and in silico. Therefore, the aim of this work is to evaluate P. emarginatus oleoresin and isolated diterpenes by in vitro anti-inflammatory models. Methods: In this study, th… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2

Citation Types

0
1
0

Year Published

2022
2022
2023
2023

Publication Types

Select...
2

Relationship

0
2

Authors

Journals

citations
Cited by 2 publications
(2 citation statements)
references
References 71 publications
0
1
0
Order By: Relevance
“…Pterodon emarginatus Vogel (Fabaceae) is a tree species of the Brazilian flora, which has proven pharmacological activities, especially anti-inflammatory (Pascoa et al, 2015;Goes et al, 2020;Lorenzi & Matos, 2021;Oliveira et al, 2023).…”
Section: Introductionmentioning
confidence: 99%
“…Pterodon emarginatus Vogel (Fabaceae) is a tree species of the Brazilian flora, which has proven pharmacological activities, especially anti-inflammatory (Pascoa et al, 2015;Goes et al, 2020;Lorenzi & Matos, 2021;Oliveira et al, 2023).…”
Section: Introductionmentioning
confidence: 99%
“…Although several biochemical pathways are known to foster the expression of secondary metabolites, the shikimic acid pathway is widely considered as the main contributor when the biosynthesis of antioxidants is concerned, especially upon drought stress (SOUZA et al, 2021;YADAV et al, 2021) mainly through phytohormones homeostasis and their signaling networks, which further initiate the biosynthesis of secondary metabolites (SMs). Among these free-radical scavenging metabolic products are monoaromatic phenolic compounds, which are acknowledged to exhibit thermodynamic feasibility to mop up reactive oxygen species, as well as interact with several bodily receptors; thereby promoting anti-inflammatory effects; gastroprotective, neuroprotective as well as anticancer activities (ALVES et al, 2020;OLIVEIRA et al, 2021;THOMAZ et al, 2018a) Regarding the building block of monoaromatic antioxidants, the good electron acceptor/donor behavior provided by the resonance allow these molecules to participate in charge-transfer reactions with many other chemical species (THOMAZ et al, 2020). Owing to this feature, many researchers have exploited the phenolic moiety as the backbone of synthetic antioxidant compounds, thereby employing medicinal chemistry strategies such as bioisosterism and latentiation to putatively enhance the antioxidant properties of these additives in dados e algoritmos de aprendizado de máquina geraram um modelo confiável e preciso para classificação imediata de antioxidantes monoaromáticos naturais e sintéticos.…”
Section: Introductionmentioning
confidence: 99%