The potential relationship of coronary artery disease and hyperuricemia: A cardiometabolic risk factor

Li, Kongwei; Yao, Qingmei; Shui, Xiaorong; Zheng, Jing; He, Yuan; Lei, Wei

doi:10.1016/j.heliyon.2023.e16097

Cited by 11 publications

(8 citation statements)

References 113 publications

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“…Related animal experiments have shown that the use of RAS inhibitors (enalapril and losartan) can prevent hypertension and arteriolar lesions caused by hyperuricemia in rats [45] . In addition, studies have shown that UA stimulates vascular smooth muscle cell proliferation by activating RAS organization in vascular smooth muscle cells, and this stimulation is mediated by UA increasing PDGF A and C chain expression, local thromboxane production, and cyclooxygenase-2 stimulation to induce specific MAPK pathways [46] . Notably, UA not only activate the RAS pathway involved in oxidative stress and inflammation but also elicits more complex inflammatory and oxidative responses when combined with AngII [47] .…”

Section: Activation Of the Rasmentioning

confidence: 99%

The relationship between hyperuricemia and hypertension: a short review of current evidence

Wang,

Yao,

Yan

et al. 2024

Metab Target Organ Damage

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The investigation of the relationship between hyperuricemia and hypertension is a captivating field in hypertension research. The final product of purine metabolism is uric acid (UA), and the elevation of serum UA (SUA) levels directly contributes to the development of hypertension. Numerous studies have substantiated that hyperuricemia is a significant risk factor for hypertension. Furthermore, initial clinical trials have demonstrated that therapeutic interventions aimed at reducing SUA levels lower blood pressure (BP) in individuals with hypertension attributed to hyperuricemia. Recent research has demonstrated that hyperuricemia can facilitate the onset of hypertension via multiple mechanisms, including oxidative stress, inflammation, diminished nitric oxide (NO) synthesis, activation of reactive oxygen species (ROS), insulin resistance, vascular smooth muscle proliferation, and renal impairment. Given the interconnectedness between hyperuricemia and hypertension, it is advantageous to identify potential therapeutic approaches for timely intervention in order to impede the advancement of hypertension in individuals with hyperuricemia. This article reviews the research progress on the pathogenesis of hyperuricemia-induced hypertension.

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Section: Activation Of the Rasmentioning

confidence: 99%

The relationship between hyperuricemia and hypertension: a short review of current evidence

Wang,

Yao,

Yan

et al. 2024

Metab Target Organ Damage

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“…Similarly, the increase of the sweat uric acid (UA) level is related to the occurrence and progression of metabolic syndrome, obesity, diabetes, coronary heart disease, and other diseases. 18,19 However, most of the current wearable sensors for UA detection are tested in exercise sweat, 20−23 and there is a lack of sensors that can detect UA in resting sweat.…”

Section: Introductionmentioning

confidence: 99%

“…Nyein et al developed wearable patches to detect resting sweat pH, Cl – , and l -dopamine for continuous and autonomous monitoring of body physiology at rest; Zhao et al analyzed stress biomarkers (cortisol, Mg 2+ , and pH) in resting sweat by integrating a wearable sweat sensing patch for diagnostic studies of psychological stress; Saha et al developed a lactate transient sensor under low sweat secretion to continuously monitor sweat lactate changes. Similarly, the increase of the sweat uric acid (UA) level is related to the occurrence and progression of metabolic syndrome, obesity, diabetes, coronary heart disease, and other diseases. , However, most of the current wearable sensors for UA detection are tested in exercise sweat, − and there is a lack of sensors that can detect UA in resting sweat.…”

Section: Introductionmentioning

confidence: 99%

Fe Single-Atom Nanozyme-Modified Wearable Hydrogel Patch for Precise Analysis of Uric Acid at Rest

Zhang,

Hou,

Zhao

et al. 2023

ACS Appl. Mater. Interfaces

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Resting sweat analysis could provide unique insight into the metabolic levels of physiological and pathological states. However, the low secretion rate of resting sweat and the low concentration of metabolic molecules pose challenges for the development of noninvasive wearable sensors. Here, we demonstrated a wearable patch for the precise analysis of uric acid at rest. Fe single-atom nanozymes (FeSAs) with excellent electrocatalytic activity were used to develop a sensor for selective catalysis of uric acid (UA, 1–425 μM), and the catalytic mechanism of UA was later explored by density functional theory. In addition, polyaniline was integrated into the wearable patch for pH detection; thus, accurate analysis of sweat UA molecules can be achieved by pH calibration. Then, we explored the possibility of collecting resting sweat with different ratios of agarose hydrogels to reduce the sweat accumulation time. Finally, the possibility of a wearable patch for accurate UA detection in volunteer sweat samples was experimentally verified. We believe that our work provides novel insights and ideas for the analysis of resting sweat using wearable devices, further driving advancements in the field of personalized medicine.

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“…Nowadays, hyperuricemia is considered one of the risk factors for the development and progression of CVD, in addition to other well-known risk factors such as AH, diabetes, dyslipidemia, and obesity. Increased levels of sUA influence the onset of CVD, specifically coronary artery disease (CAD), through many different pathological mechanisms [8]. Atherosclerosis is known as an inflammatory disease and sUA itself induces inflammation by causing the production and activation of different inflammatory factors, also the extracellular signal-regulated kinase (ERK) and p38 mitogen-activated protein kinase (MAPK) cascade reaction [8][9][10].…”

Section: Introductionmentioning

confidence: 99%

“…Increased levels of sUA influence the onset of CVD, specifically coronary artery disease (CAD), through many different pathological mechanisms [8]. Atherosclerosis is known as an inflammatory disease and sUA itself induces inflammation by causing the production and activation of different inflammatory factors, also the extracellular signal-regulated kinase (ERK) and p38 mitogen-activated protein kinase (MAPK) cascade reaction [8][9][10]. Increased sUA levels also reduce nitric oxide (NO) production, which is one of the factors in the development of endothelial dysfunction, which is considered an early manifestation of the atherosclerosis process [11].…”

Section: Introductionmentioning

confidence: 99%

Effect of Alcohol Consumption Habits on Early Arterial Aging in Subjects with Metabolic Syndrome and Elevated Serum Uric Acid

et al. 2023

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Background: Hyperuricemia is perceived as one of the risk factors for developing and progressing cardiovascular disease and metabolic syndrome through various pathological mechanisms. Endogenous synthesis and exogenous factors such as diet and beverages consumed play a major role in determining serum uric acid (sUA) levels. The aim of this study was to evaluate the effect of alcohol consumption on early arterial aging in middle-aged patients with metabolic syndrome (MetS) and hyperuricemia. Materials and Methods: This study included 661 middle-aged subjects (241 men and 420 women) from the Lithuanian High Cardiovascular Risk (LitHiR) primary prevention program. Characteristics of subjects such as blood pressure, laboratory testing, and the specialized nutrition profile questionnaire were evaluated. As an early marker of arterial stiffness, carotid–femoral pulse wave velocity (cfPWV) was assessed using a non-invasive applanation tonometry technique. Results: Hyperuricemia was present in 29% of men and 34% of women. Hyperuricemic men reported 1.6 times higher rates of alcohol drinking compared to men with normal sUA levels. After analyzing the correlation between alcohol consumption and cfPWV, no statistically significant relationships were found at a significance level of α = 0.05 but lowering the significance level to 0.06 revealed significant associations in men with normal sUA (ε2ordinal = 0.05, p = 0.06) and in women with increased sUA levels (ε2ordinal = 0.05, p = 0.08). Regression analysis showed that hyperuricemic men, consuming more than one unit of alcohol per week, had a significant impact on increasing cfPWV, while men with normal sUA levels, abstaining from alcohol entirely, resulted in a statistically significant decrease in cfPWV. Our results showed statistically significant relationships only among a group of men, although the women in the hyperuricemic group had a statistically higher cfPWV than women with normal sUA levels. Conclusions: Drinking alcohol is associated with increased arterial stiffness among hyperuricemic middle-aged men with MetS.

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The potential relationship of coronary artery disease and hyperuricemia: A cardiometabolic risk factor

Cited by 11 publications

References 113 publications

The relationship between hyperuricemia and hypertension: a short review of current evidence

The relationship between hyperuricemia and hypertension: a short review of current evidence

Fe Single-Atom Nanozyme-Modified Wearable Hydrogel Patch for Precise Analysis of Uric Acid at Rest

Effect of Alcohol Consumption Habits on Early Arterial Aging in Subjects with Metabolic Syndrome and Elevated Serum Uric Acid

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