The potential role of adjunctive ascorbic acid in the prevention of colistin-induced nephrotoxicity in critically ill patients: A retrospective study

Sulaiman, Khalid Al; Aljuhani, Ohoud; Alhammad, Abdullah; Aamer, Kholoud Al; Alshehri, Sara; Alhuwahmel, Abdulmohsen; Kharbosh, Abdullah; Alshehri, Areej; Shareef, Hanan Al; Sulaihim, Ibrahim Al; Alghamdi, Albandari; Harbi, Shmeylan Al; Vishwakarma, Ramesh; Abdan, Numan; Alrajhi, Yousef; Katheri, Abdulmalik Al; Alenazi, Abeer A.; Alalawi, Mai; Ghamdi, Ghassan Al

doi:10.1016/j.jsps.2022.10.003

Cited by 2 publications

(2 citation statements)

References 24 publications

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“…Nowadays, natural antioxidants, rather than chemical drugs, are used as protective agents against organ damage in many diseases [17]. Polyphenols are herbal agents abundant in marine pine bark and contain some antioxidant flavonoids [18,19]. Despite the fact that data regarding the biological functions of polyphenols are abundant, evidence is still inadequate to support the clear beneficial effects on human chronic diseases [20].…”

Section: Introductionmentioning

confidence: 99%

Renoprotective Effect of Taxifolin in Paracetamol-Induced Nephrotoxicity: Emerging Evidence from an Animal Model

Topal

Özdamar

ÇATAKLI>

et al. 2023

JCM

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Background: Taxifolin (TXF) is a flavonoid found abundantly in citrus/onion. Encouraging results on its renoprotective effect have been reported in a limited number of drug-induced nephrotoxicity animal models. The present study aimed to evaluate for the first time the potential renoprotective effects of TXF in a paracetamol (PAR)-induced nephrotoxicity rat model. Methods: Rats were divided into three equal groups (n = 6 animals per group). Group 1 (PAR group, PARG) received PAR diluted in normal saline by gavage (1000 mg/kg). Group 2 (TXF group, TXFG) received TXF diluted in normal saline by gavage (50 mg/kg) one hour after PAR administration. Group 3 (control group, CG) received normal saline. Twenty-four hours after PAR administration, all animals were sacrificed using high-dose anesthesia. Blood samples were collected and kidneys were removed. Results: The serum blood urea nitrogen, creatinine levels and serum malondialdehyde levels were significantly increased in the PARG. The serum glutathione peroxidase, glutathione reductase and total glutathione levels were significantly higher in the TXFG. At the same time, the kidneys of the PARG animals demonstrated tubular epithelium swelling, distension and severe vacuolar degeneration. The kidneys of the TXFG animals showed mildly dilated/congested blood vessels. Conclusions: The TXF renoprotective effects are promising in preventing PAR-induced nephrotoxicity, mainly through antioxidant activity, and warrant further testing in future studies.

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Section: Introductionmentioning

confidence: 99%

Renoprotective Effect of Taxifolin in Paracetamol-Induced Nephrotoxicity: Emerging Evidence from an Animal Model

Topal

Özdamar

ÇATAKLI>

et al. 2023

JCM

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“…In particular, ascorbic acid and carotenoids were reported for their role in protection against oxidative damage and cell aging [ 27 , 28 ].…”

Section: Introductionmentioning

confidence: 99%

Voghera Sweet Pepper: A Potential Ally against Oxidative Stress and Aging

Gola

Gaiaschi

Roda

et al. 2023

IJMS

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In the present study, the potential functional properties of the extracts from the edible part of Capsicum annuum L. var. Peperone di Voghera (VP) were studied. The phytochemical analysis revealed a high amount of ascorbic acid, paralleled by a low carotenoid content. Normal human diploid fibroblasts (NHDF) were chosen as the in vitro model models to investigate the effects of the VP extract on oxidative stress and aging pathways. The extract of Carmagnola pepper (CP), another important Italian variety, was used as the reference vegetable. The cytotoxicity evaluation was performed firstly, using a 3-(4,5-dimethylthiazolyl-2)-2,5-diphenyltetrazolium bromide (MTT) assay, while the VP potential antioxidant and antiaging activity was investigated by immunofluorescence staining focusing on specifically selected proteins. The MTT data revealed the highest cell viability at a concentration of up to 1 mg/mL. The immunocytochemical analyses highlighted an increased expression of transcription factors and enzymes involved in redox homeostasis (Nrf2, SOD2, catalase), improved mitochondrial functionality, and the up-regulation of the longevity gene SIRT1. The present results supported the functional role of the VP pepper ecotype, suggesting a feasible use of its derived products as valuable food supplements.

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The potential role of adjunctive ascorbic acid in the prevention of colistin-induced nephrotoxicity in critically ill patients: A retrospective study

Cited by 2 publications

References 24 publications

Renoprotective Effect of Taxifolin in Paracetamol-Induced Nephrotoxicity: Emerging Evidence from an Animal Model

Renoprotective Effect of Taxifolin in Paracetamol-Induced Nephrotoxicity: Emerging Evidence from an Animal Model

Voghera Sweet Pepper: A Potential Ally against Oxidative Stress and Aging

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