The (potential) role of apolipoproteins in nasal mucus of allergic rhinitis patients

Tomazic, Peter Valentin; Birner-Grünberger, Ruth; Obrist, Britta; Spörk, Stefan; Leitner, Anita; Lang‐Loidolt, Doris

doi:10.1186/2045-7022-4-s2-p19

Cited by 3 publications

(2 citation statements)

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“…The compositional alterations of HDL are closely linked to alterations of HDL functional properties [29]. Other studies reported an increase in apoA-I and apoA-II, which are the major HDL apolipoproteins, in the mucus proteome of allergic rhinitis patients, suggesting a direct modulation of the immune response by HDL apolipoproteins [127][128][129]. Increased apoA-I levels were also detected in nasal lavage fluids of subjects with persulfate-associated rhinitis after challenge with potassium persulfate [130].…”

Section: Allergic Rhinitis Is Associated With Complex Alterations In ...mentioning

confidence: 94%

High-Density Lipoprotein (HDL) in Allergy and Skin Diseases: Focus on Immunomodulating Functions

Trakaki

Marsche

2020

Biomedicines

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From an evolutionary perspective, lipoproteins are not only lipid transporters, but they also have important functions in many aspects of immunity. High-density lipoprotein (HDL) particles are the most abundant lipoproteins and the most heterogeneous in terms of their composition, structure, and biological functions. Despite strong evidence that HDL potently influences the activity of several immune cells, the role of HDL in allergies and skin diseases is poorly understood. Alterations in HDL-cholesterol levels have been observed in allergic asthma, allergic rhinitis, atopic dermatitis (eczema), psoriasis, urticaria, and angioedema. HDL-associated apolipoprotein (apo) A-I, apoA-IV, and apoC-III, and lyso-phosphatidylcholines potently suppress immune cell effector responses. Interestingly, recent studies provided evidence that allergies and skin diseases significantly affect HDL composition, metabolism, and function, which, in turn, could have a significant impact on disease progression, but may also affect the risk of cardiovascular disease and infections. Interestingly, not only a loss in function, but also, sometimes, a gain in function of certain HDL properties is observed. The objective of this review article is to summarize the newly identified changes in the metabolism, composition, and function of HDL in allergies and skin diseases. We aim to highlight the possible pathophysiological consequences with a focus on HDL-mediated immunomodulatory activities.

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Section: Allergic Rhinitis Is Associated With Complex Alterations In ...mentioning

confidence: 94%

High-Density Lipoprotein (HDL) in Allergy and Skin Diseases: Focus on Immunomodulating Functions

Trakaki

Marsche

2020

Biomedicines

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“…In a previous report, Tomazic et al, revealed the presence of apoA-IV in mucus samples of allergic rhinitis patients [ 43 , 108 ]. Similar to allergy, chronic rhinosinusitis is characterized by a pronounced eosinophilic inflammation of the lining of the nose and paranasal sinuses.…”

Section: Apolipoproteinsmentioning

confidence: 99%

Role of Short Chain Fatty Acids and Apolipoproteins in the Regulation of Eosinophilia-Associated Diseases

Sturm

Knuplez

Marsche

2021

IJMS

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Eosinophils are key components of our host defense and potent effectors in allergic and inflammatory diseases. Once recruited to the inflammatory site, eosinophils release their cytotoxic granule proteins as well as cytokines and lipid mediators, contributing to parasite clearance but also to exacerbation of inflammation and tissue damage. However, eosinophils have recently been shown to play an important homeostatic role in different tissues under steady state. Despite the tremendous progress in the treatment of eosinophilic disorders with the implementation of biologics, there is an unmet need for novel therapies that specifically target the cytotoxic effector functions of eosinophils without completely depleting this multifunctional immune cell type. Recent studies have uncovered several endogenous molecules that decrease eosinophil migration and activation. These include short chain fatty acids (SCFAs) such as butyrate, which are produced in large quantities in the gastrointestinal tract by commensal bacteria and enter the systemic circulation. In addition, high-density lipoprotein-associated anti-inflammatory apolipoproteins have recently been shown to attenuate eosinophil migration and activation. Here, we focus on the anti-pathogenic properties of SCFAs and apolipoproteins on eosinophil effector function and provide insights into the potential use of SCFAs and apolipoproteins (and their mimetics) as effective agents to combat eosinophilic inflammation.

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Allergic rhinitis is associated with complex alterations in high-density lipoprotein composition and function

Trakaki

Sturm

Pregartner

et al. 2019

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biolog

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The (potential) role of apolipoproteins in nasal mucus of allergic rhinitis patients

Cited by 3 publications

References 0 publications

High-Density Lipoprotein (HDL) in Allergy and Skin Diseases: Focus on Immunomodulating Functions

High-Density Lipoprotein (HDL) in Allergy and Skin Diseases: Focus on Immunomodulating Functions

Role of Short Chain Fatty Acids and Apolipoproteins in the Regulation of Eosinophilia-Associated Diseases

Allergic rhinitis is associated with complex alterations in high-density lipoprotein composition and function

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