The potential role of Bifidobacterium spp. as a preventive and therapeutic agent in controlling inflammation via affecting inflammatory signalling pathways

Aghamohammad, Shadi; Sepehr, Amin; Miri, Seyedeh Tina; Najafi, Saeideh; Pourshafie, Mohammad Reza; Rohani, Mahdi

doi:10.1111/lam.13793

Cited by 9 publications

(4 citation statements)

References 31 publications

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“…One study pointed out that Bifidobacterium strains inhibit inflammation by regulating the inflammatory pathway and could be used as a supplementary treatment for IBD. 51 The increase in Bifidobacterium was related to the success of anti-TNF-α treatment. 52 However, some studies have different opinions.…”

Section: Discussionmentioning

confidence: 99%

Selenium Yeast Alleviates Dextran Sulfate Sodium-Induced Chronic Colitis in Mice by Reducing Proinflammatory Cytokines and Regulating the Gut Microbiota and Their Metabolites

Wu,

Li,

Jiang

et al. 2024

JIR

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Background Inflammatory bowel disease (IBD) is a chronic recurrent gastrointestinal inflammatory disease. Selenium has been reported to have therapeutic potential in IBD. Selenium yeast is a common selenium supplement that is convenient to access. This study explored the effect of selenium yeast on dextran sulfate sodium- (DSS-)induced chronic colitis in mice. Methods Mice were randomly divided into four groups: the control group, selenium yeast group, chronic colitis group, and chronic colitis+selenium yeast group (n=6). Mice were killed on the 26th day. The disease activity index (DAI) score and histological damage score were calculated. Cytokines, serum selenium, colonic tissue selenium, gut microbiota and their metabolites short-chain fatty acids (SCFAs) were evaluated. Results Selenium yeast lowered IL-1β, IL-6, TNF-α, IL-17A, IL-22 and IFN-γ ( P <0.05). In addition, selenium yeast significantly elevated Turicibacter, Bifidobacterium, Allobaculum, Prevotella, Halomonas, Adlercreutzia ( P <0.05), and butyric acid ( P <0.05). Conclusion Selenium yeast could improve DSS-induced chronic colitis in mice by regulating cytokines, gut microbiota and their metabolites.

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Section: Discussionmentioning

confidence: 99%

Selenium Yeast Alleviates Dextran Sulfate Sodium-Induced Chronic Colitis in Mice by Reducing Proinflammatory Cytokines and Regulating the Gut Microbiota and Their Metabolites

Wu,

Li,

Jiang

et al. 2024

JIR

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“…Immunomodulatory effect was evaluated by measuring reduction of LPS-stimulated IL-8 secretion by bifidobacteria strains in a HT-29 cell culture model. This model was largely described in literature [ 33 , 50 – 58 ] with different stimulants at various concentrations to induce inflammatory response and different incubation times. Here, the model was adapted for high throughput screening to a 96-well MTP assay and optimal amount of HT29 cells per well, cell/bacteria ratio, LPS concentration and incubation times were defined after multiple tests during method set-up.…”

Section: Methodsmentioning

confidence: 99%

Taxonomic and phenotypic analysis of bifidobacteria isolated from IBD patients as potential probiotic strains

Bosselaar,

Dhelin,

Dautel

et al. 2024

BMC Microbiol

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Background Inflammatory Bowel Diseases (IBD) are a major public health issue with unclear aetiology. Changes in the composition and functionality of the intestinal microbiota are associated with these pathologies, including the depletion of strict anaerobes such as Feacalibacterium prausnitzii. Less evidence is observed for depletion in other anaerobes, among which bifidobacteria. This study characterized the taxonomic and functional diversity of bifidobacteria isolated from the human intestinal microbiota in active and non-active IBD patients by a culturomics approach and evaluated if these bifidobacteria might be used as probiotics for gut health. Results A total of 341 bifidobacteria were isolated from the intestinal microbiota of IBD patients (52 Crohn’s disease and 26 ulcerative colitis patients), with a high proportion of Bifidobacterium dentium strains (28% of isolated bifidobacteria). In ulcerative colitis, the major species identified was B. dentium (39% of isolated bifidobacteria), in active and non-active ulcerative colitis. In Crohn’s disease, B. adolescentis was the major species isolated from non-active patients (40%), while similar amounts of B. dentium and B. adolescentis were found in active Crohn’s disease patients. The relative abundance of B. dentium was increased with age, both in Crohn’s disease and ulcerative colitis and active and non-active IBD patients. Antibacterial capacities of bifidobacteria isolated from non-active ulcerative colitis against Escherichia coli LF82 and Salmonella enterica ATCC 14028 were observed more often compared to strains isolated from active ulcerative colitis. Finally, B. longum were retained as strains with the highest probiotic potential as they were the major strains presenting exopolysaccharide synthesis, antibacterial activity, and anti-inflammatory capacities. Antimicrobial activity and EPS synthesis were further correlated to the presence of antimicrobial and EPS gene clusters by in silico analysis. Conclusions Different bifidobacterial taxonomic profiles were identified in the microbiota of IBD patients. The most abundant species were B. dentium, mainly associated to the microbiota of ulcerative colitis patients and B. adolescentis, in the intestinal microbiota of Crohn’s disease patients. Additionally, the relative abundance of B. dentium significantly increased with age. Furthermore, this study evidenced that bifidobacteria with probiotic potential (antipathogenic activity, exopolysaccharide production and anti-inflammatory activity), especially B. longum strains, can be isolated from the intestinal microbiota of both active and non-active Crohn’s disease and ulcerative colitis patients.

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“…Probiotics may act by ameliorating oxidative stress, repairing the intestinal barrier, or performing immunomodulation. Most of the strains of probiotics currently used as adjunctive therapy for IBD belong to the Lactobacillus and Bifidobacterium genera, which are probably miracle powers for curing IBD (Aghamohammad et al., 2022; Hasannejad‐Bibalan et al., 2020; Qin et al., 2022). Some Lactobacillus have been shown to restore altered immune cell ratios, reduce inflammation, and more (Je et al., 2018).…”

Section: Application Status and Concernsmentioning

confidence: 99%

Probiotic characterization of Bacillus smithii: Research advances, concerns, and prospective trends

Zhao,

Huang,

Liu

et al. 2024

Comp Rev Food Sci Food Safe

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Bacillus smithii is a thermophilic Bacillus that can be isolated from white wine, hot spring soil, high‐temperature compost, and coffee grounds, with various biofunctions and wide applications. It is resistant to both gastric acid and high temperature, which makes it easier to perform probiotic effects than traditional commercial probiotics, so it can maintain good vitality during food processing and has great application prospects. This paper starts with the taxonomy and genetics and focuses on aspects, including genetic transformation, functional enzyme production, waste utilization, and application in the field of food science as a potential probiotic. According to available studies during the past 30 years, we considered that B. smithii is a novel class of microorganisms with a wide range of functional enzymes such as hydrolytic enzymes and hydrolases, as well as resistance to pathogenic bacteria. It is available in waste degradation, organic fertilizer production, the feed and chemical industries, the pharmaceutical sector, and food fortification. Moreover, B. smithii has great potentials for applications in the food industry, as it presents high resistance to the technological processes that guarantee its health benefits. It is also necessary to systematically evaluate the safety, flavor, and texture of B. smithii and explore its biological mechanism of action, which is of great value for further application in multiple fields, especially in food and medicine.

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The potential role of Bifidobacterium spp. as a preventive and therapeutic agent in controlling inflammation via affecting inflammatory signalling pathways

Cited by 9 publications

References 31 publications

Selenium Yeast Alleviates Dextran Sulfate Sodium-Induced Chronic Colitis in Mice by Reducing Proinflammatory Cytokines and Regulating the Gut Microbiota and Their Metabolites

Selenium Yeast Alleviates Dextran Sulfate Sodium-Induced Chronic Colitis in Mice by Reducing Proinflammatory Cytokines and Regulating the Gut Microbiota and Their Metabolites

Taxonomic and phenotypic analysis of bifidobacteria isolated from IBD patients as potential probiotic strains

Probiotic characterization of Bacillus smithii: Research advances, concerns, and prospective trends

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