The potential role of extracellular vesicles in bioactive compound-based therapy: A review of recent developments

Liu, Huifan; Liang, Jiaxi; Xia, Ye; Huang, Miaoru; Ma, Lukai; Xie, Xi; Liu, Dongjie; Cao, Hui; Simal-Gándara, Jesús; Rengasamy, Kannan R.R.; Wang, Qin; Xiao, Gengsheng; Xiao, Jianbo

doi:10.1080/10408398.2022.2081667

Cited by 5 publications

(7 citation statements)

References 111 publications

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“…However, it is postulated that donor cell cytoplasmic proteins and RNA-enriched EVs can have the potential to modulate the stress response mechanisms of recipient cells. Moreover, EVs are widely accepted for their physiochemical traits to foster therapeutic applications primarily on EV-delivered bioactive compounds (mRNA, miRNA, long non-coding RNAs, DNAs, proteins, and lipids) with biological regulatory functions ( Liu et al, 2022 ). Exosome-mediated transfer of miRNA in bovine follicular GCs has been evidenced in our previous study ( Sohel et al, 2013 ).…”

Section: Discussionmentioning

confidence: 99%

Granulosa cell-derived extracellular vesicles mitigate the detrimental impact of thermal stress on bovine oocytes and embryos

Menjivar

Gad

Gebremedhn

et al. 2023

Front. Cell Dev. Biol.

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Climate change-induced global warming results in rises in body temperatures above normal physiological levels (hyperthermia) with negative impacts on reproductive function in dairy and beef animals. Extracellular vesicles (EVs), commonly described as nano-sized, lipid-enclosed complexes, harnessed with a plethora of bioactive cargoes (RNAs, proteins, and lipids), are crucial to regulating processes like folliculogenesis and the initiation of different signaling pathways. The beneficial role of follicular fluid-derived EVs in inducing thermotolerance to oocytes during in vitro maturation (IVM) has been evidenced. Here we aimed to determine the capacity of in vitro cultured granulosa cell-derived EVs (GC-EVs) to modulate bovine oocytes’ thermotolerance to heat stress (HS) during IVM. Moreover, this study tested the hypothesis that EVs released from thermally stressed GCs (S-EVs) shuttle protective messages to provide protection against subsequent HS in bovine oocytes. For this, sub-populations of GC-EVs were generated from GCs subjected to 38.5°C (N-EVs) or 42°C (S-EVs) and supplemented to cumulus-oocyte complexes (COCs) matured in vitro at the normal physiological body temperature of the cow (38.5°C) or HS (41°C) conditions. Results indicate that S-EVs improve the survival of oocytes by reducing ROS accumulation, improving mitochondrial function, and suppressing the expression of stress-associated genes thereby reducing the severity of HS on oocytes. Moreover, our findings indicate a carryover impact from the addition of GC-EVs during oocyte maturation in the development to the blastocyst stage with enhanced viability.

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Section: Discussionmentioning

confidence: 99%

Granulosa cell-derived extracellular vesicles mitigate the detrimental impact of thermal stress on bovine oocytes and embryos

Menjivar

Gad

Gebremedhn

et al. 2023

Front. Cell Dev. Biol.

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“…By contrast to purification methods used in other studies, this method was mainly based on cell disruption and centrifugation steps, with the vesicles being more similar to those that could be formed in the organism after food consumption because additional purification steps after isolation, such as filtration, were not carried out 75,76 . Thus, the membrane vesicles obtained possess suitable physicochemical properties for use as nanocarriers in biotechnological applications, given that they are natural vesicles composed of sustainable and biodegradable materials that can be isolated in large quantities 22 …”

Section: Discussionmentioning

confidence: 99%

“…plant–animal). These vesicles contain natural bioactive compounds, such as lipids, proteins, RNAs or other active components 22,23 . Recently, advances have been made on elucidating the functions of plant‐derived membrane vesicles on mammals through in vitro assays.…”

Section: Introductionmentioning

confidence: 99%

“…These vesicles contain natural bioactive compounds, such as lipids, proteins, RNAs or other active components. 22,23 Recently, advances have been made on elucidating the functions of plant-derived membrane vesicles on mammals through in vitro assays. For example, vesicles isolated from grapes showed a protective effect against colitis, 24 broccoli vesicles exerted an anti-inflammatory activity in macrophages 25 and citrus membrane vesicles inhibited cell proliferation of cancer cells without affecting normal cells.…”

Section: Introductionmentioning

confidence: 99%

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Exploring membrane vesicles in citrus fruits: a comparative analysis of conventional and organic farming approaches

Olmos‐Ruiz,

Garcia‐Gomez,

Carvajal

et al. 2023

J Sci Food Agric

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BackgroundRecently, vesicles derived from plant cell membranes received attention for their potential use as active biomolecules and nanocarriers, and obtaining them from organic crops may be an interesting option, as different farming systems can affect production, plant secondary metabolism, and biochemistry of cell membranes. This study aims to determine how organic and conventional farming affect the mineral nutrition, gas exchange, CO2 fixation, and biochemical composition of lemon fruits, which could have an impact on the different fractions of cell membranes in pulp and juice.ResultsThe results showed that organic trees had higher intrinsic water use efficiency (WUEi) but conventional trees had higher stomatal conductance (gs) and nitrogen use efficiency (NUtE). Also, organic lemons had significantly higher levels of some micronutrients (Ca, Cu, Fe, and Zn). Secondly, the main differences in the membrane vesicles showed that organic pulp vesicles had a higher antioxidant activity and more oleic acid, while both types of vesicles from conventional lemons had more linoleic acid.ConclusionsIn conclusion, organic farming did not alter carbon fixation parameters but impacted nitrogen fixation and water uptake, and resulted in higher micronutrient levels in lemons. These mineral nutritional changes could be related to the higher production of membranes that showed suitable morphological traits and a high antioxidant activity, positively correlated with a high amount of oleic acid, which could have stronger cell protection characteristics.This article is protected by copyright. All rights reserved.

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“…Exosomes are endosomal membrane-derived vesicles, approximately 50–150 nm in size, formed during endocytosis and secreted by almost all types of cells, and are present in large numbers in body fluids such as blood, urine, cerebrospinal fluid, tears, and saliva. Their main constituents are lipids, proteins, and nucleic acids, including microRNAs (miRNAs), messenger RNA (mRNA), and DNA derived from secretory cells transferred to other cells [ 12 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 , 85 , 86 , 87 , 88 , 89 , 90 , 91 , 92 , 93 , 94 , 95 , 96 , 97 , 98 , 99 , 100 , 101 , 102 , 103 , 104 , 105 , 106 ,…”

Section: Introductionmentioning

confidence: 99%

Regulation of Extracellular Vesicle-Mediated Immune Responses against Antigen-Specific Presentation

Matsuzaka

Yashiro

2022

Vaccines

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Extracellular vesicles (EVs) produced by various immune cells, including B and T cells, macrophages, dendritic cells (DCs), natural killer (NK) cells, and mast cells, mediate intercellular communication and have attracted much attention owing to the novel delivery system of molecules in vivo. DCs are among the most active exosome-secreting cells of the immune system. EVs produced by cancer cells contain cancer antigens; therefore, the development of vaccine therapy that does not require the identification of cancer antigens using cancer-cell-derived EVs may have significant clinical implications. In this review, we summarise the molecular mechanisms underlying EV-based immune responses and their therapeutic effects on tumour vaccination.

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The potential role of extracellular vesicles in bioactive compound-based therapy: A review of recent developments

Cited by 5 publications

References 111 publications

Granulosa cell-derived extracellular vesicles mitigate the detrimental impact of thermal stress on bovine oocytes and embryos

Granulosa cell-derived extracellular vesicles mitigate the detrimental impact of thermal stress on bovine oocytes and embryos

Exploring membrane vesicles in citrus fruits: a comparative analysis of conventional and organic farming approaches

Regulation of Extracellular Vesicle-Mediated Immune Responses against Antigen-Specific Presentation

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