The potential role of ferroptosis in COVID-19-related cardiovascular injury

Yang, Lei; Wu, Yunyi; Jin, Weidong; Mo, Nan; Ye, Gaoqi; Su, Zixin; Tang, Lusheng; Wang, Ying; Li, Yanchun; Du, Jing

doi:10.1016/j.biopha.2023.115637

Cited by 7 publications

(2 citation statements)

References 178 publications

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“…These PUFA-OOH molecules become key players in lipid peroxidation, a process linked to ferroptosis. This coordinated dance of biochemical events highlights the profound impact of lipid metabolism on the composition of cellular membranes and the generation of lipid mediators crucial for various cellular processes, including the intriguing phenomenon of ferroptosis ( Figure 2 ) ( Yang et al, 2023a ).…”

Section: Overview Of Ferroptosismentioning

confidence: 99%

Ferroptosis-related exosomal non-coding RNAs: promising targets in pathogenesis and treatment of non-malignant diseases

Zhang,

Xie

2024

Front. Cell Dev. Biol.

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Ferroptosis, an iron-dependent form of programmed cell death, introduces a novel perspective on cellular demise. This study investigates the regulatory network of exosomal non-coding RNAs (ncRNAs), including miRNAs, circRNAs, and lncRNAs, in ferroptosis modulation. The primary goal is to examine the pathological roles of ferroptosis-related exosomal ncRNAs, particularly in ischemic reperfusion injuries. The research reveals intricate molecular interactions governing the regulatory interplay between exosomal ncRNAs and ferroptosis, elucidating their diverse roles in different non-malignant pathological contexts. Attention is given to their impact on diseases, including cardiac, cerebral, liver, and kidney ischemic injuries, as well as lung, wound, and neuronal injuries. Beyond theoretical exploration, the study provides insights into potential therapeutic applications, emphasizing the significance of mesenchymal stem cells (MSCs)-derived exosomes. Findings underscore the pivotal role of MSC-derived exosomal ncRNAs in modulating cellular responses related to ferroptosis regulation, introducing a cutting-edge dimension. This recognition emphasizes the importance of MSC-derived exosomes as crucial mediators with broad therapeutic implications. Insights unveil promising avenues for targeted interventions, capitalizing on the diverse roles of exosomal ncRNAs, providing a comprehensive foundation for future therapeutic strategies.

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Section: Overview Of Ferroptosismentioning

confidence: 99%

Ferroptosis-related exosomal non-coding RNAs: promising targets in pathogenesis and treatment of non-malignant diseases

Zhang,

Xie

2024

Front. Cell Dev. Biol.

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“…Similarly, a dysregulation of iron homeostasis including anemia of inflammation has been observed in patients with COVID-19 [ 75 ]. Recently, ferroptosis has been identified as a potential cause of cell death in sepsis and cardiovascular damages in COVID-19 patients [ 76 ]. While iron accumulation in macrophages can promote pathogen destruction, ferroptosis can also lead to the death of macrophages and facilitate bacterial invasion [ 22 , 77 ].…”

Section: Sources Of Catalytic Iron In Critically Ill Patientsmentioning

confidence: 99%

Iron as an emerging therapeutic target in critically ill patients

Grange,

Lux,

Brichart

et al. 2023

Crit Care

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The multiple roles of iron in the body have been known for decades, particularly its involvement in iron overload diseases such as hemochromatosis. More recently, compelling evidence has emerged regarding the critical role of non-transferrin bound iron (NTBI), also known as catalytic iron, in the care of critically ill patients in intensive care units (ICUs). These trace amounts of iron constitute a small percentage of the serum iron, yet they are heavily implicated in the exacerbation of diseases, primarily by catalyzing the formation of reactive oxygen species, which promote oxidative stress. Additionally, catalytic iron activates macrophages and facilitates the growth of pathogens. This review aims to shed light on this underappreciated phenomenon and explore the various common sources of NTBI in ICU patients, which lead to transient iron dysregulation during acute phases of disease. Iron serves as the linchpin of a vicious cycle in many ICU pathologies that are often multifactorial. The clinical evidence showing its detrimental impact on patient outcomes will be outlined in the major ICU pathologies. Finally, different therapeutic strategies will be reviewed, including the targeting of proteins involved in iron metabolism, conventional chelation therapy, and the combination of renal replacement therapy with chelation therapy.

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