The potential role of G2- but not of G0-radiosensitivity for predisposition of prostate cancer

Borgmann, Kerstin; Raabe, Annette; Reuther, Sebastian; Szymczak, Silke; Schlomm, Thorsten; Isbarn, Hendrik; Gomolka, Maria; Busjahn, Andreas; Bonin, Michael; Ziegler, Andreas; Dikomey, Ekkehard

doi:10.1016/j.radonc.2010.04.018

Cited by 17 publications

(14 citation statements)

References 41 publications

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“…With reference to the ring construction mechanism in chromosomal injury, no ring will be expected to be seen at doses less than 1 Gy. Detecting no difference between the PCC rings yields of the healthy and prostate cancer cases can confirm Borgmann et al, [ 13 ] consideration about endpoints. This means that the genomic problems of prostate cancer patients do not show themselves in the form of rings in the chemical PCC test, as they did not show themselves in dicentric test in Borgmann et al, [ 13 ] experiment.…”

Section: Discussionsupporting

confidence: 62%

“…One of the most important studies done for comparing healthy individuals with prostate cancer patients from the raddiosensitivity point of view is that of Borgmann et al, [ 13 ]. They claimed that healthy and prostate cancer cases demonstrate no difference from radiosensitivity point of view based on the dicentric test and G 0 phase, while they reported a significant difference based on G 2 phase.…”

Section: Discussionmentioning

confidence: 99%

“…Borgmann et al, [ 13 ] used dicentric test for the comparison of healthy individuals and prostate cancer patients after irradiation of their lymphocytes in G 0 and G 2 phases. Their results showed that there was no significant difference between the two groups in G 0 unlike G 2 phase which demonstrated a significant difference.…”

Section: Introductionmentioning

confidence: 99%

“…Considering other researches registering differences between healthy individuals and cancerous patients using MN assay in G 0 phase, Borgmann et al, declared that it was possible that the mechanism of identifying chromosomal aberrations was different in dicentric and MN assays or the radiosensitivity of lymphocytes in various cancers as being different [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

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Comparing Lymphocyte Radiosensitivity of Prostate Cancer Patients with Healthy Donors using Micronuclei and Chemical Premature Chromosome Condensation Tests

Golfam

Hashemi

Haeri³

et al. 2019

jbpe

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Background: Cytogenetic tests are usually used for diagnosing predisposed individuals to cancer by determining their lymphocyte radiosensitivity. Objective: To determine the potential role of radiosensitivity in predisposition of prostate cancer by comparing lymphocyte radiosensitivity of prostate cancer patients with healthy donors. Materials and Methods: In this experimental study, the blood samples of 10 prostate cancer patients and 10 healthy donors were irradiated to 0.25, 0.5, 1, 2, 4 and 6 Gy ionizing radiation produced by a 6MV Linac. One sample of each group receiving no radiation was regarded as the background. The micronuclei (MN) and chemical premature chromosome condensation (PCC) cytogenetic tests were performed on all samples and the numbers of MN and PCC rings were scored. Dose-response curves were plotted for both healthy and cancerous groups with two tests. Results: There was a significant difference between the numbers of MN within each group due to different levels of radiation doses. There was also a significant difference between the two groups in all identical doses, with the exception of 6 Gy. The chemical PCC test indicated a significant difference between the scored PCC rings in each group at doses higher than 0.25 Gy. However, no differences were noted between the healthy donors and prostate cancer patients receiving the same level of doses. Conclusion: MN test can be considered as a reliable indicator of predisposition of prostate cancer. On the other hand, the chemical PCC test could not differentiate between healthy donors and prostate cancer patients at the dose range examined in this study.

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Section: Discussionsupporting

confidence: 62%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Comparing Lymphocyte Radiosensitivity of Prostate Cancer Patients with Healthy Donors using Micronuclei and Chemical Premature Chromosome Condensation Tests

Golfam

Hashemi

Haeri³

et al. 2019

jbpe

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“…Radiosensitivity, a trait of utmost relevance for cancer in terms of causality as well as therapy, was studied based on cultured blood cells from MZ twins (Borgmann et al, 2007(Borgmann et al, , 2010.…”

Section: Major Research Focus and Findingsmentioning

confidence: 99%

HealthTwiSt: The Berlin Twin Registry for Health Research

Busjahn¹

2012

Twin Res Hum Genet

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The Berlin Twin Registry has its focus on health research. It is operated as a private company, making twin studies available to academic institutions as well as commercial partners in the area of biotechnology and nutrition. Recruitment is based on invitation in the context of mass media coverage of scientific results. Phenotyping in the unselected twin subjects is directed toward intermediate phenotypes that can bear on common diseases. These phenotypes include proteomic approaches and gene expression. Some results are briefly described to give an impression of the range of research topics and related opportunities for retrospective and prospective collaborative research. RecruitmentOur main recruitment strategy is to increase awareness of the twin registry's existence, along with the uniqueness of twins in research. This includes mass media advertisements for specific projects as well as publication of results in nonscientific newspapers. Motivation comes from demonstrating value for the general population as well as the individual benefits for the twins who participate. As an incentive for participation, we provide a free health checkup and free zygosity testing to twins. Aside from recruiting new twin pairs, keeping in contact with the current registry members is the second important part of maintaining a vibrant twin registry. While some twins will have been participating in ongoing studies, a larger portion may either not be suitable for the current projects or currently not available. It is crucial to keep ties and maintain involvement even if no immediate participation is possible. Regular newsletters and participation in local twin conventions are currently our main activities; extensions to our Web site for interaction between twins are under development. Data and SamplesData storage is accomplished in a MySQL database with Web front end. This includes all personal as well as phenotypic information. A major part of our internal resources are devoted to the continuing database development.In most projects, complex measurement schemes are applied to balance effort in recruitment, time strain for the twins, and scientific value. As long as there is a balance between research interest and burden to the twins, combining studies is a suitable strategy to maximize the power of phenotyping in twins.Our twin sample is a self-selected adult sample with a wide age range (38 ± 15 years) (Table 1) without specific diseases; we have directed our phenotyping at intermediate traits and studied the influence of genetic variability on normal physiological variation. Direct measurements of traits like blood pressure were extended by functional assays to determine venous function (e.g., Brinsuk et al., 2004). Molecular phenotyping has been included in one study in which we counted the percentage of neutrophils expressing Proteinase 3 on their cell surface as a potential risk factor for Wegener granulomatosis, finding a heritability of 0.99

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Strahlenresistenzforschung

Petersen

Dikomey

2011

Forum

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The potential role of G2- but not of G0-radiosensitivity for predisposition of prostate cancer

Cited by 17 publications

References 41 publications

Comparing Lymphocyte Radiosensitivity of Prostate Cancer Patients with Healthy Donors using Micronuclei and Chemical Premature Chromosome Condensation Tests

Comparing Lymphocyte Radiosensitivity of Prostate Cancer Patients with Healthy Donors using Micronuclei and Chemical Premature Chromosome Condensation Tests

HealthTwiSt: The Berlin Twin Registry for Health Research

Strahlenresistenzforschung

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