The potential role of Piper guineense (black pepper) in managing geriatric brain aging: a review

Abstract

Brain aging is one of the unavoidable aspects of geriatric life. As one ages, changes such as the shrinking of certain parts (particularly the frontal cortex, which is vital to learning and other complex mental activities) of the brain may occur. Consequently, communications between neurons are less effective, and blood flow to the brain could also decrease. efforts made at the biological level for repair become inadequate, leading to the accumulation of β-amyloid peptide in the brain faster than its probable degradation mechanism, resulting in cognitive malfunction. Subsequent clinical usage of drugs in battling related brain-aging ailments has been associated with several undesirable side effects. However, recent research has investigated the potential use of natural compounds from food in combating such occurrences. This review provides information about the use of Piper guineense (black pepper) as a possible agent in managing brain aging because of its implications for practical brain function. P. guineense contains an alkaloid (piperine) reported to be an antioxidant, anti-depressant, and central nervous system stimulant. This alkaloid and other related compounds are neuroprotective agents that reduce lipid oxidation and inhibit tangles in the brain tissues.

Amide Alkaloids as Privileged Sources of Senomodulators for Therapeutic Purposes in Age-Related Diseases

“…When added at 70 μM, ROS production, SASP secretome, and SA-β-gal activity were all reduced, while cell division, marked by ERK1/2 phosphorylation, was recovered, ultimately leading to differentiation, migration, and survival . Furthermore, piperine has been shown to be neuroprotective in several models of brain aging and AD models. ,,− ,− Piperine was shown to promote reduction of lipid peroxidation, inhibition of acetylcholinesterase (AchE) and restoration of monoamine neurotransmission as well as neurotrophic effect in hippocampus, slowing down cognitive impairments in brain aging and AD context …”