The Potential Role of IL-6 in Monitoring Coronavirus Disease 2019

Liu, Tao; Zhang, Jieying; Yang, Yuhui; Zhang, Liling; Ma, Hong; Li, Zhengyu; Zhang, Jiaoyue; Cheng, Ji; Zhang, Xiaoyun; Wu, Gang; Yi, Jianhua

doi:10.2139/ssrn.3548761

Cited by 58 publications

(91 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Further analysis demonstrated that the variations of IL6 were closely related to the disease progression of COVID-19 patients. This result is consistent with a previous study, which suggests IL6 as an effective target for disease monitoring and treatment [14,21] . IL6, as an acute phase inflammatory cytokine, plays an important role in regulating inflammatory responses.…”

Section: Discussionsupporting

confidence: 94%

Potential Factors for Prediction of Disease Severity of COVID-19 Patients

zhang

wang

et al. 2020

Preprint

View full text Add to dashboard Cite

Objective: Coronavirus disease 2019 is an escalating global epidemic caused by SARS-CoV-2, with a high mortality in critical patients. Effective indicators for predicting disease severity in SARS-CoV-2 infected patients are urgently needed. Methods: In this study, 43 COVID-19 patients admitted in ChongqingPublic Health Medical Center were involved. Demographic data, clinical features, and laboratory examinations were obtained through electronic medical records. Peripheral blood specimens were collected from COVID-19 patients and examined for lymphocyte subsets and cytokine profiles by flow cytometry. Potential contributing factors for prediction of disease severity were further analyzed.Results: A total of 43 COVID-19 patients were included in this study, including 29 mild patients and 14 sever patients. Severe patients were significantly older (61.9±9.4 vs 44.4±15.9) and had higher incidence in co-infection with bacteria compared to mild group (85.7%vs27.6%).Significantly more severe patients had the clinical symptoms of anhelation (78.6%) and asthma (71.4%). For laboratory examination, 57.1% severe cases showed significant reduction in lymphocyte count.The levels of Interluekin-6 (IL6), IL10, erythrocyte sedimentation rate (ESR) and D-Dimer (D-D) were significantly higher in severe patients than mild patients, while the level of albumin (ALB) was remarkably : medRxiv preprint lower in severe patients. Further analysis demonstrated that ESR, D-D, age, ALB and IL6 were the major contributing factors for distinguishing severe patients from mild patients. Moreover, ESR was identified as the most powerful factor to predict disease progression of COVID-19 patients. Conclusion:Age and the levels of ESR, D-D, ALB and IL6 are closely related to the disease severity of COVID-19 patients. ESR can be used as a valuable indicator for distinguishing severe COVID-19 patients in early stage, so as to increase the survival of severe patients.

show abstract

Section: Discussionsupporting

confidence: 94%

Potential Factors for Prediction of Disease Severity of COVID-19 Patients

zhang

wang

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…Also, high levels of lactate dehydrogenase (LDH), and ferritin are suggestive due to the cytokine storm in Laboratory ndings. Also, elevated Ferritin and Lactate dehydrogenase (LDH) levels due to cytokine storm syndrome have been reported in severe COVID-19 patients (13). In hospitalized patients, serum ferritin testwhich is widely available and affordable-is a good quali ed screening tool for informing physicians of cytokine storm syndrome for COVID-19 patients (14).…”

Section: Introductionmentioning

confidence: 99%

Diagnosis of Coronavirus disease by measuring serum concentrations of IL-6 and blood Ferritin

Yazdanpanah

Vafaei

Javdansirat

et al. 2020

Preprint

View full text Add to dashboard Cite

Objectives: Coronavirus disease 2019 (COVID-19) associated by infection and high death rate. The unresolved questions about the fatality rate of COVID-19 is most probably related to cytokine storm syndrome. There is currently no specific medication. Understanding the pathogenic pathway of this disease will lead to production of treatment and decreases of death rate. The aim of this study is to investigate changes of peripheral blood parameters (Interleukin-6 and Ferritin) in COVID-19 patients, which may be beneficial in the management of patients.Methods: In this case-control study, we collected data of 270 subjects in two groups including 133 patients with severe type COVID-19 (case) and 137 patients with nonsevere (control) between March 20 and May 21, 2020, and the clinical symptoms and inflammatory indications of patients diagnosed by laboratory test in Shahid Jalil hospital of Yasuj University of medical Sciences were collected to explore potential markers for disease monitoring. The data were analyzed by SPSS software version 20. Descriptive statistics, T-test and bivariate correlation tests were used to analyze. Results: The enrolled COVID-19 patients consisted of 53.4% males and 46.6% females with the medium age of 45.56±18.55 years and there were 50.04% males and 49.6% females with the medium age of 45.59±17.0 years for non COVID-19 patients. There was no significant difference in the age and sex ratio between two population under study. The proportion interstitial abnormalities evidenced by CT imaging in COVID-19 patients was 91.0%, while, 4.4% abnormalities was found in non COVID-19 patients. The frequency of positive RT-PCR test for case and control groups were 88.0% and 3.6%, respectively. The mean IL-6 and Ferritin levels and hematological parameters in two groups of patients with COVID-19 and non- COVID-19, were significantly different across all comparisons.There was a direct positively correlated between serum level of IL-6, Ferritin levels and hematological parameters including WBC, Lymphocytes, Neutrophils and Hb, except for platelets (negatively correlate), with COVID-19. Conclusions: In conclusion, inflammatory markers specifically IL-6 and Ferritin and hematological parameters (WBC, Lymphocytes, Neutrophils, Platelet and Hb) were correlated with the severity of COVID-19. Measurement of IL-6, Ferritin and hematological indices might be workable tests to diagnosis and prognosis of patients with COVID-19.

show abstract

“…Among cytokines, specificity of IL-6 in COVID-19 comes from that Elevated IL-6 is correlated with inflammatory cytokine storm severity. therefore targeting IL-6 and its receptor (IL6R) by Siltuximab and tocilizumab monoclonal antibodies (mAb) Could mitigate cytokine storm-related symptoms in severe COVID-19 patients [13].…”

Section: Discussionmentioning

confidence: 99%