The Potential Role of Korean Mistletoe Extract as an Anti-Inflammatory Supplementation

Ha, Sol; Kim, Ji-Hyeon; Kim, Jong-Won; Kim, Do-Yeon; Ha, Min‐Seong

doi:10.1155/2021/2183427

Cited by 4 publications

(7 citation statements)

References 37 publications

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“…A lack of alterations in performance with VA is in direct opposition to previous reports although no changes in HR are supported [13,14]. In contrast to current findings, Ha et al used an identical exercise bout but showed improved rowing efficiency (i.e., individuals took fewer strokes to complete the rowing trial in a similar time) following 8 weeks of twice-daily VA supplementation [14].…”

Section: Discussioncontrasting

confidence: 89%

“…Although VA has been used for centuries in folk medicine, the nutraceutical benefits have only recently been empirically investigated. Initial studies in animals and humans support the use of chronic VA supplementation as a means to improve aerobic exercise performance and possibly enhance oxidative capacity [2,4,14]. However, little to no information exists as to whether an acute dose of VA, which may be more practical for some individuals, imparts a performance enhancement.…”

Section: Discussionmentioning

confidence: 99%

“…Although VA is tolerated well in moderate to low doses, these factors are important for consideration in practical applications as some lectins in VA have cytotoxic properties and can result in illness when it is taken in larger quantities [28]. However, no adverse effects were noted with the current oral dosage and previous oral supplementation protocols have shown similar findings with chronic supplementation [14]. Future dose-response exercise studies with VA will be imperative in developing ideal dietary enrichment guidelines for performance enhancement and safety.…”

Section: Discussionmentioning

confidence: 99%

“…To date, only a small number of studies investigating VA and exercise performance exist in humans with almost exclusive use of chronic dosing protocols [13,14]. Lim et al reported increased knee strength and balance in elderly males and females with 12 weeks of VA supplementation [13].…”

Section: Introductionmentioning

confidence: 99%

“…Lim et al reported increased knee strength and balance in elderly males and females with 12 weeks of VA supplementation [13]. Furthermore, Ha et al reported that 8 weeks of twice-daily VA supplementation enhanced endurance rowing capacity and lowered inflammatory markers in young males [14]. While intriguing, chronic inter-day recurring dosing strategies may not be practical and/or desirable to some athletes and recreational exercisers.…”

Section: Introductionmentioning

confidence: 99%

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Effects of Acute Mistletoe (Viscum album L.) Ingestion on Aerobic Exercise Performance

Goode¹,

Duser²,

Rogers³

et al. 2022

Nutraceuticals

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Mistletoe (Viscum album L.; VA) has been traditionally used in folk medicine to combat fatigue and stress. Evidence has shown that chronic consumption of VA results in an enhancement of oxidative metabolism and exercise performance. However, no studies have investigated how acute VA consumption influences performance. The purpose of this brief report was to investigate the effects of acute VA ingestion on rowing exercise performance. Physically active females were recruited for this study. In a crossover, counterbalanced design, participants completed two trials each with a different treatment: (1) VA (2000 mg) and (2) placebo (PL; gluten-free cornstarch; 2000 mg). A total of 30 minutes prior to exercise, participants consumed their treatment. The participants were familiarized with the rowing ergometer and warmed up for 5 min at 50% of age-predicted heart rate max. Immediately following the warm-up, the participants completed a 2000 m rowing time trial. Blood lactate (La) was obtained with a lactate meter via finger prick before and after exercise. Power output, trial time, heart rate, rating of perceived exertion (RPE), and La were analyzed. The findings revealed no significant differences for the relative power output (p = 0.936), trial time (p = 0.842) or heart rate (p = 0.762). Rating of perceived exertion was lower with VA ingestion (p = 0.027). La was significantly higher post-exercise regardless of treatment (p < 0.001). However, post-exercise La was lower with VA ingestion (p = 0.032). Findings do not support VA as an ergogenic aid but suggest ingestion may alter metabolism resulting in less La formation and subjective fatigue.

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Section: Discussioncontrasting

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effects of Acute Mistletoe (Viscum album L.) Ingestion on Aerobic Exercise Performance

Goode¹,

Duser²,

Rogers³

et al. 2022

Nutraceuticals

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Sacha Inchi (Plukenetia volubilis L.) Protein Hydrolysate as a New Ingredient of Functional Foods

Lemus-Conejo,

Villanueva-Lazo,

Martin

et al. 2024

Foods

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Sacha inchi (Plukenetia volubilis L.) is an under-exploited crop with great potential due to its nutritional and medicinal characteristics. A Sacha inchi protein isolate (SII), obtained from defatted Sacha inchi flour (SIF), was hydrolyzed by Bioprotease LA 660 under specific conditions. The hydrolysates were characterized chemically, and their digestibility and antioxidant capacity were evaluated by in vitro cell-free experiments to select the hydrolysate with major antioxidant activity. Sacha inchi protein hydrolysate at 20 min (SIH20B) was selected, and the anti-inflammatory capacity was evaluated by RT-qPCR and ELISA techniques, using two different doses in monocytes THP-1 stimulated with lipopolysaccharide (LPS). The results obtained showed that the in vitro administration of SIH20B down-regulated the TNF-α gene and reduced the release of this cytokine, whereas the anti-inflammatory cytokines IL-10 and IL-4 were up-regulated in LPS-stimulated monocytes and co-administrated with SIH20B. The peptides contained in SIH20B were identified, and the 20 more relatively abundant peptides with a mass by 1 kDa were subjected to in silico analysis to hypothesize those that could be responsible for the bioactivity reported in the hydrolysate. From the identified peptides, the peptides AAGALKKFL and LGVKFKGGL, among others, are proposed as the most biologically actives. In conclusion, SIH20B is a novel, natural source of high-value-added biopeptides that could be used as an ingredient in formulations of food or nutraceutical compounds.

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The Anti-Inflammatory Activity of Viscum album

Nicoletti

2023

Plants

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The therapeutic story of European mistletoe (Viscum album L.) presents a seesawing profile. In ancient times, this hemiparasitic plant was considered a panacea and even to be endowed with exceptional beneficial properties. In more recent times, despite its multiple uses in traditional medicines, some parts of the plant, in particular the berries, were considered poisonous and dangerous, including concerns of cytotoxicity, which spread serious suspicion on its medicinal utility. However, since the last century, medical interest in mistletoe has come back in force due to its utilization in clinical cancer treatments, based on its selective action on tumor cells. In Central Europe, the hydro-alcoholic extracts of European mistletoe register a relevant and continuous utilization in anthroposophic medicine, which is a holistic system that includes the utilization of phytomedicinal substances. In Switzerland and Germany, most physicians and patients use these products as complementary therapy in oncological treatments. However, despite its increasing use in this field, the results of mistletoe’s use are not always convincing, and other aspects have appeared. Nowadays, products that contain mistletoe are utilized in several fields, including diet, phytotherapy, veterinary medicine and homeopathy, but in particular in cancer therapies as coadjuvant factors, in consideration of several positive effects including effects in the improvement of quality-of-life conditions and reinforcement of the immune system. In this review, based on the understanding of the association between cancer and inflammation, we propose a relationship between these recent uses of mistletoe, based on its antioxidant properties, which are supported by phytochemical and pharmacological data. The unicity of mistletoe metabolism, which is a direct consequence of its hemiparasitism, is utilized as a key interpretation element to explain its biological properties and steer its consequent therapeutic uses.

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The Potential Role of Korean Mistletoe Extract as an Anti-Inflammatory Supplementation

Cited by 4 publications

References 37 publications

Effects of Acute Mistletoe (Viscum album L.) Ingestion on Aerobic Exercise Performance

Effects of Acute Mistletoe (Viscum album L.) Ingestion on Aerobic Exercise Performance

Sacha Inchi (Plukenetia volubilis L.) Protein Hydrolysate as a New Ingredient of Functional Foods

The Anti-Inflammatory Activity of Viscum album

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