2023
DOI: 10.1101/2023.12.19.572348
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The potential role of liquid-liquid phase separation in the cellular fate of the compartments for unconventional protein secretion

Luis Felipe S. Mendes,
Carolina O. Gimenes,
Marília D. O. da Silva
et al.

Abstract: Eukaryotic cells have developed sophisticated mechanisms for biomolecule transport, particularly under stress conditions. This study focuses on the unconventional protein secretion (UPS) pathways activated during starvation stress, facilitating the export of soluble leaderless proteins. Specifically, we examine the role of the GRASP family, which is crucial in these processes but has largely unexplored mechanisms, especially regarding the biogenesis and cargo recruitment for the vesicular-like compartment for … Show more

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