The Potential Role of Minoxidil in the Hair Transplantation Setting

Avram, Marc R.; Cole, John P.; Chase, Chevy; Gandelman, Marcelo; Haber, Robert; Knudsen, Russell; Leavitt, Matt; Leonard, Robert T.; Puig, Carlos J.; Rose, Paul T.; Vogel, James E.; Ziering, Craig

doi:10.1046/j.1524-4725.2002.02068.x

Cited by 41 publications

(13 citation statements)

References 20 publications

(26 reference statements)

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“…Complications include temporary loss of hair adjacent to the donor and recipient area due to decreased blood supply at the incision site, infection, pain, and failure of the transplanted hair to grow. The use of topical minoxidil may increase hair density and speed the regrowth of transplanted follicles following the surgical procedure 127. Referral to a dedicated and reputable hair transplantation specialist should be offered to those patients who desire this therapy.…”

Section: Treatmentmentioning

confidence: 99%

Female pattern alopecia: current perspectives

Levy¹,

Emer²

2013

IJWH

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Hair loss is a commonly encountered problem in clinical practice, with men presenting with a distinctive pattern involving hairline recession and vertex balding (Norwood-Hamilton classification) and women exhibiting diffuse hair thinning over the crown (increased part width) and sparing of the frontal hairline (Ludwig classification). Female pattern hair loss has a strikingly overwhelming psychological effect; thus, successful treatments are necessary. Difficulty lies in successful treatment interventions, as only two medications – minoxidil and finasteride – are approved for the treatment of androgenetic alopecia, and these medications offer mediocre results, lack of a permanent cure, and potential complications. Hair transplantation is the only current successful permanent option, and it requires surgical procedures. Several other medical options, such as antiandrogens (eg, spironolactone, oral contraceptives, cyproterone, flutamide, dutasteride), prostaglandin analogs (eg, bimatoprost, latanoprost), and ketoconazole are reported to be beneficial. Laser and light therapies have also become popular despite the lack of a profound benefit. Management of expectations is crucial, and the aim of therapy, given the current therapeutic options, is to slow or stop disease progression with contentment despite patient expectations of permanent hair regrowth. This article reviews current perspectives on therapeutic options for female pattern hair loss.

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Section: Treatmentmentioning

confidence: 99%

Female pattern alopecia: current perspectives

Levy¹,

Emer²

2013

IJWH

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“…Both minoxidil and finasteride have been approved by the US Food and Drug Administration for use in AGA. 5,12 Although the mechanism of action of minoxidil is not completely understood, it has been shown 5 to slow the rate of hair loss and, to a much lesser extent, increase hair growth and survival. The use of finasteride, a 5-a reductase inhibitor, is based on the association between AGA and androgen exposure.…”

mentioning

confidence: 99%

“…12 Hair restoration surgery in mainstream medicine dates back to the 1950s, and the seminal article describing this technique details the use of 4-mm punch grafts. 16 Today the most widely used technique is micrografting by the traditional strip method or the follicular unit extraction method.…”

mentioning

confidence: 99%

Perception of Hair Transplant for Androgenetic Alopecia

Bater

Ishii

Joseph

et al. 2016

JAMA Facial Plast Surg

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IMPORTANCEHair transplant is among the most common cosmetic services sought by men, with more than 11 000 procedures performed in 2014. Despite its growing popularity, the effect of hair transplant on societal perceptions of youth, attractiveness, or facets of workplace and social success is unknown.OBJECTIVES To determine whether hair transplant improves observer ratings of age, attractiveness, successfulness, and approachability in men treated for androgenetic alopecia and to quantify the effect of hair transplant on each of these domains. DESIGN, SETTING, AND PARTICIPANTSA randomized controlled experiment was conducted from November 10 to December 6, 2015, using web-based surveys featuring photographs of men before and after hair transplant. One hundred twenty-two participants recruited through various social media platforms successfully completed the survey. Observers were shown 2 side-by-side images of each man and asked to compare the image on the left with the one on the right. Of 13 pairs of images displayed, 7 men had undergone a hair transplant procedure and 6 had served as controls. Observers evaluated each photograph using various metrics, including age, attractiveness, successfulness, and approachability. A multivariate analysis of variance was performed to understand the effect of hair transplant on observer perceptions. Planned posthypothesis testing was used to identify which variables changed significantly as a result of the transplant. MAIN OUTCOMES AND MEASURESObserver ratings of age (in number of years younger) and attractiveness, successfulness, and approachability (on a scale of 0 to 100; scores higher than 50 indicate a positive change). RESULTSOf the 122 participants in the survey, 58 were men (47.5%); mean (range) age was 27.1 (18-52) years. The initial multivariate analysis of variance revealed a statistically significant multivariate effect for transplant (Wilks λ = 0.9646; P < .001). Planned posthypothesis analyses were performed to examine individual differences across the 4 domains. Findings determined with t tests showed a significant positive effect of hair transplant on observers' perceptions of age (mean [SD] number of years younger, 3.6 [2.9] years; P < .001), attractiveness (mean [SD] score, 58.5 [17.5]; P < .001), successfulness (mean [SD] score, 57.1 [17.1]; P = .008), and approachability (mean [SD] score, 59.2 [18.1]; P = .02).CONCLUSIONS AND RELEVANCE Men were perceived as being younger and more attractive by casual observers after undergoing hair transplant. Participants also rated posttransplant faces as appearing more successful and approachable relative to their pretransplant counterparts. These aspects have been shown to play a substantial role in both workplace and social success, and these data demonstrate that hair transplant can improve ratings universally across all 4 domains. LEVEL OF EVIDENCE NA.

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“…This clearly indicated that no new hair follicles formed in the treated areas. As an OTC drug for hair re-growth, minoxidil is known to dilate blood vessels surrounding hair bulbs and enhance the delivery of oxygen and nutrients to the cells of hair follicles [ 37 ]. However, the exact mechanism of the stimulation of hair growth is not known.…”

Section: Resultsmentioning

confidence: 99%

In vivo evaluation of insect wax for hair growth potential

Zhang

et al. 2018

PLoS ONE

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Insect wax is secreted by Ericerus pela Chavanness. It has been traditionally used to treat hair loss in China, but few reports have been published on the hair growth-promoting effect of insect wax. In this work, we examined the hair growth-promoting effects of insect wax on model animals. Different concentrations of insect wax were topically applied to the denuded backs of mice, and 5% minoxidil was applied topically as a positive control. We found that insect wax significantly promoted hair growth in a dose-dependent manner, 45% and 30% insect wax both induced hair to regrow, while less visible hair growth was observed in blank controls on the 16th day. The experimental areas treated with 45% and 30% insect wax exhibited significant differences in hair scores compared to blank controls, and hair lengths in the 45% and 30% insect wax group was significantly longer than in blank controls on the 16th and 20th days. There were no new hair follicles forming in the treated areas, and the hair follicles were prematurely converted to the anagen phase from the telogen phase in experimental areas treated with 45% and 30% insect wax. Both 45% and 30% insect wax upregulated vascular endothelial growth factor expression. The results indicated that 45% and 30% insect wax showed hair growth-promoting potential approximately as potent as 5% minoxidil by inducing the premature conversion of telogen-to-anagen and by prolonging the mature anagen phase rather than increasing the number of hair follicles, which was likely related to the upregulation of VEGF expression. The dissociative policosanol in insect wax was considered the key ingredient most likely responsible for the hair growth promoting potential.

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The Potential Role of Minoxidil in the Hair Transplantation Setting

Cited by 41 publications

References 20 publications

Female pattern alopecia: current perspectives

Female pattern alopecia: current perspectives

Perception of Hair Transplant for Androgenetic Alopecia

In vivo evaluation of insect wax for hair growth potential

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