The potential role of miR‐29 in health and cancer diagnosis, prognosis, and therapy

Alizadeh, Mohammad; Safarzadeh, Ali; Beyranvand, Fatemeh; Ahmadpour, Fatemeh; Hajiasgharzadeh, Khalil; Baghbanzadeh, Amir; Baradaran, Behzad

doi:10.1002/jcp.28607

Cited by 59 publications

(50 citation statements)

References 200 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The miR-29 family is one of the most intensively examined groups of miRNAs. Previous studies have revealed that miR-29 plays an important role in various biological processes such as cell proliferation, apoptosis, invasion and angiogenesis and that downregulation of the miR-29 family is associated with aging, pathogenesis of neurodegenerative or fibrotic diseases, as well as tumor development and progression (19,20). However, there is little information regarding miRNAs in peritoneal fluid.…”

Section: Introductionmentioning

confidence: 99%

Reduced expression of exosomal miR‑29s in peritoneal fluid is a useful predictor of peritoneal recurrence after curative resection of gastric cancer with serosal involvement

et al. 2020

View full text Add to dashboard Cite

The peritoneal surface is the most frequent site of metastasis disease in patients with gastric cancer. Even after curative surgery and adjuvant chemotherapy, peritoneal recurrences often develop. Exosomes play pivotal roles in tumor metastasis via the transfer of microRNAs (miRNAs). In the present study, exosomes were isolated from peritoneal lavage fluid or ascites in 85 patients with gastric cancer and the relative expression levels of miR-29s were examined. The expression of miR-29a-3p, miR-29b-3p and miR-29c-3p in peritoneal exosomes were all downregulated in patients with peritoneal metastases (PM) compared to those without PM. In 30 patients who underwent curative gastrectomy with serosa-involved (T4) gastric cancer, 6 patients exhibited recurrence in the peritoneum within 12 months. The expression levels of miR-29s at gastrectomy tended to be lower in these 6 patients than in the other 24 patients with significant differences in miR-29b-3p (P=0.003). When the patients were divided into two groups based on median levels of miR-29s, peritoneal recurrence developed more frequently in patients with low expression of miR-29b-3p, and lower expression of miR-29s were related with worse overall survival. miR-29s are thought to play a suppressive role in the growth of disseminated peritoneal tumor cells. Reduced expression of miR-29b in peritoneal exosomes is a strong risk factor of developing postoperative peritoneal recurrence.

show abstract

Section: Introductionmentioning

confidence: 99%

Reduced expression of exosomal miR‑29s in peritoneal fluid is a useful predictor of peritoneal recurrence after curative resection of gastric cancer with serosal involvement

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Deregulation of miRNAs frequently occurs in cancer and is thought to play critical roles in all aspects of tumorigenesis. Here, we investigated the deregulation of miR-29, a miRNA with tumor suppressive properties in various cancer types (reviewed in (Alizadeh et al 2019 Previous studies have shown that p53 regulates the expression of both miR-29b1~a and miR-29b2~c (Ugalde et al 2011;Chen et al 2018). However, our results indicate that transcription of miR-29b1~a is independent of p53, both in MEFs and in melanocytes.…”

Section: Discussionmentioning

confidence: 99%

“…The miR-29 family is encoded by two clusters, miR-29b1~a and miR-29b2~c, located on chromosomes 7q32.2 and 1q32.2 in humans, respectively (Kriegel et al 2012;Alizadeh et al 2019). Expression of the miR-29 clusters produces primary transcripts pri-miR-29b1~a and pri-miR-29b2~c, which are processed to generate three mature miRNAs, miR-29a, miR-29b, and miR-29c, that are highly conserved across species and share identical seed sequences (Kriegel et al 2012).…”

Section: Introductionmentioning

confidence: 99%

MAPK-induced miR-29 targets MAFG and suppresses melanoma development

Vera

Bok

Jasani

et al. 2020

Preprint

View full text Add to dashboard Cite

The tumor suppressive miR-29 family of microRNAs is encoded by two clusters, miR-29b1~a and miR-29b2~c, and is regulated by several oncogenic and tumor suppressive stimuli. Here we investigated whether oncogenic MAPK hyperactivation regulates miR-29 abundance and how this signaling axis impacts melanoma development. Using mouse embryonic fibroblasts and human melanocytes, we found that oncogenic MAPK signaling stimulates p53-independent and p53-dependent transcription of pri-miR-29b1~a and pri-miR-29b2~c, respectively. Expression analyses revealed that while pri-miR-29a~b1 remains elevated, pri-miR-29b2~c levels decrease during melanoma progression. Using a rapid mouse modeling platform, we showed that inactivation of miR-29 in vivo accelerates the development of frank melanomas and decreases overall survival. We identified MAFG as a relevant miR-29 target that has oncogenic potential in melanocytes and is required for growth of melanoma cells. Our findings suggest that MAPK-driven miR-29 induction constitutes a tumor suppressive barrier by targeting MAFG, which is overcome by attenuation of miR-29b2~c expression.

show abstract

“…Three groups of miRNAs, namely miR-29, miR-34 family, and miR-223, exhibited pro-and anti-calcification properties in different reports ( Table 1). The MiR-29 family contain three members, namely miR-29a, 29b, and 29c; these members exhibit immunoregulatory ability, affect muscle cell physiology, and modulate cell survival [98]. Experiments based on rat, human VSMCs, and calcified arteries from rat showed that miR-29a/29b/29c could ameliorate [14,34,44] or aggravate [26,32] calcification progression (Table 1).…”

Section: Mirnas With Controversial Influences On Vcmentioning

confidence: 99%

The Epigenetic Landscape of Vascular Calcification: An Integrative Perspective

Hou

Yuan

et al. 2020

IJMS

View full text Add to dashboard Cite

Vascular calcification (VC) is an important complication among patients of advanced age, those with chronic kidney disease, and those with diabetes mellitus. The pathophysiology of VC encompasses passive occurrence of physico-chemical calcium deposition, active cellular secretion of osteoid matrix upon exposure to metabolically noxious stimuli, or a variable combination of both processes. Epigenetic alterations have been shown to participate in this complex environment, through mechanisms including DNA methylation, non-coding RNAs, histone modifications, and chromatin changes. Despite such importance, existing reviews fail to provide a comprehensive view of all relevant reports addressing epigenetic processes in VC, and cross-talk between different epigenetic machineries is rarely examined. We conducted a systematic review based on PUBMED and MEDLINE databases up to 30 September 2019, to identify clinical, translational, and experimental reports addressing epigenetic processes in VC; we retrieved 66 original studies, among which 60.6% looked into the pathogenic role of non-coding RNA, followed by DNA methylation (12.1%), histone modification (9.1%), and chromatin changes (4.5%). Nine (13.6%) reports examined the discrepancy of epigenetic signatures between subjects or tissues with and without VC, supporting their applicability as biomarkers. Assisted by bioinformatic analyses blending in each epigenetic component, we discovered prominent interactions between microRNAs, DNA methylation, and histone modification regarding potential influences on VC risk.

show abstract

The potential role of miR‐29 in health and cancer diagnosis, prognosis, and therapy

Cited by 59 publications

References 200 publications

Reduced expression of exosomal miR‑29s in peritoneal fluid is a useful predictor of peritoneal recurrence after curative resection of gastric cancer with serosal involvement

Reduced expression of exosomal miR‑29s in peritoneal fluid is a useful predictor of peritoneal recurrence after curative resection of gastric cancer with serosal involvement

MAPK-induced miR-29 targets MAFG and suppresses melanoma development

The Epigenetic Landscape of Vascular Calcification: An Integrative Perspective

Contact Info

Product

Resources

About