The potential role of miRNAs in the pathogenesis of salivary gland cancer – A Focus on signaling pathways interplay

Abulsoud, Ahmed I.; Elshaer, Shereen Saeid; El-Husseiny, Ahmed A.; Fathi, Doaa; Abdelmaksoud, Nourhan M.; Mageed, Sherif S. Abdel; Salman, Aya; Zaki, Mohamed Bakr; El-Mahdy, Hesham A.; Ismail, Ahmed; Elsakka, Elsayed G.E.; Abd-Elmawla, Mai A.; El-Husseiny, Hussein M.; Ibrahim, Wael; Doghish, Ahmed S.

doi:10.1016/j.prp.2023.154584

Cited by 36 publications

(1 citation statement)

References 166 publications

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“…Normally, there is a balance between the demyelination and remyelination processes inside the brain. miRNAs play an essential role in numerous diseases. − One of the main mechanisms that modulates neuronal remyelination is the production of microRNAs, especially miR-146a, which is known to contribute to repairing demyelinated lesions . Consequently, miR-146a is considered a vital target for different therapeutic approaches in treating MS. Nowadays, there are different treatment strategies for MS; however, none of them provide a complete cure for the disease. − Therefore, continuous studies are interested in attaining a therapeutic tool that may give promise for alleviating MS symptoms .…”

Section: Introductionmentioning

confidence: 99%

Modulating miR-146a Expression by Hydrogen Sulfide Ameliorates Motor Dysfunction and Axonal Demyelination in Cuprizone-Induced Multiple Sclerosis

Ghaiad

Abd-Elmawla

Gad

et al. 2023

ACS Chem. Neurosci.

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Multiple sclerosis (MS) is a progressive neuro-inflammatory and neuro-autoimmune disease. Although hydrogen sulfide has recently shown potential therapeutic impacts in different neurological diseases, its effects on MS are still obscure. MiR-146a is considered a vital target for different therapeutic approaches in treating MS. The present study is directed to explore the therapeutic effects of NaHS (hydrogen sulfide donor) on cuprizone-induced MS and to explore whether NaHS can mediate its effects via regulating miR-146a expression. A total of 28 male C57Bl/6 mice were divided into 4 groups; control, cuprizone-intoxicated, NaHS control (100 μmol/kg/day, i.p), and NaHS-treated groups. Intriguingly, NaHS treatment managed to improve locomotor coordination and curb neuronal inflammation and demyelination as evidenced by hematoxylin & eosin, and Luxol fast blue staining and the increased myelin basic protein (MBP) content. Additionally, NaHS reduced interleukin-1 receptorassociated kinase-1 (IRAK-1), nuclear transcription factor kappa B (NF-κB), interleukin (IL)-17, and IL-1β brain levels along with downregulation of miR-146a expression compared with the untreated cuprizone-intoxicated group. Furthermore, NaHS-treated animals revealed much less oxidative stress compared to the untreated animals as evidenced by elevated glutathione and reduced malondialdehyde contents. Altogether, the current work reported that NaHS could improve motor dysfunction and reduce axonal demyelination, oxidative stress, as well as neuro-inflammation in mice with MS. Thus, using H 2 S-releasing compounds could be a promising approach in MS treatment strategies. The mechanism of these beneficial effects may involve the regulation of miR-146a/ NF-κB/IL-1β axis.

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