The potential role of miRNAs 21 and 199-a in early diagnosis of hepatocellular carcinoma

Amr, Khalda; Ezzat, Wafaa M.; Elhosary, Yasser A.; Hegazy, Abdelfattah E.; Fahim, Hoda H.; Kamel, Rabab

doi:10.1016/j.gene.2015.08.038

Cited by 56 publications

(37 citation statements)

References 35 publications

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“…In tissues, high expression of miR-18b-5p, miR-200a-3p, miR-200b-3p, miR-21-5p, miR-224-5p and miR-29-5p were most frequently to be detected in HCC, and miR-139-5p was down-regulated. Therefore, they were valuable for diagnosis of HCC3951525354555657. Several circulating miRNA biomarkers also displayed signally correlation with tissue invasion and metastasis, including highly expressed miR-146a-5p, miR-181b-5p, miR-182-5p, miR-21-5p, miR-215, miR-24-3p, miR-224-5p, miR-296-5p, miR-331-3p and miR-96-5p and low expressed miR-125b-5p, miR-199a-3p, miR-122-5p, miR-139-5p, miR-150-5p, miR-195-5p and miR-19a-3p.…”

Section: Resultsmentioning

confidence: 99%

“…Senescence, just like apoptosis, is as a protective system that could be activated by opposite growth signals or shortened telomeres that drives abnormal cells irreversibly into a G0-like state, and it could prevent further proliferation31. High expression of miR-182-5p, miR-18b-5p, miR-21-5p and miR-224-5p, together with the down-regulated expression of miR-101-3p and miR-139-5p not only played important roles in the regulation of cell proliferation and limitless replicative potential, but also were diagnostic signals for HCC3839515254555685. High expression of miR-106b-5p, miR-21-5p, miR-331-3p and low expression of miR-101-3p, miR-125b-5p, miR-139-5p had great potential to be noninvasive and accurate circulating biomarkers for HCC preliminary screening103851555661.…”

Section: Resultsmentioning

confidence: 99%

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Biomarker MicroRNAs for Diagnosis, Prognosis and Treatment of Hepatocellular Carcinoma: A Functional Survey and Comparison

Shen

Lin

Yuan

et al. 2016

Sci Rep

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Hepatocellular Carcinoma (HCC) is one of the most common malignant tumors with high incidence and mortality rate. Precision and effective biomarkers are therefore urgently needed for the early diagnosis and prognostic estimation. MicroRNAs (miRNAs) are important regulators which play functions in various cellular processes and biological activities. Accumulating evidence indicated that the abnormal expression of miRNAs are closely associated with HCC initiation and progression. Recently, many biomarker miRNAs for HCC have been identified from blood or tissues samples, however, the universality and specificity on clinicopathological features of them are less investigated. In this review, we comprehensively surveyed and compared the diagnostic, prognostic, and therapeutic roles of HCC biomarker miRNAs in blood and tissues based on the cancer hallmarks, etiological factors as well as ethnic groups, which will be helpful to the understanding of the pathogenesis of biomarker miRNAs in HCC development and further provide accurate clinical decisions for HCC diagnosis and treatment.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Biomarker MicroRNAs for Diagnosis, Prognosis and Treatment of Hepatocellular Carcinoma: A Functional Survey and Comparison

Shen

Lin

Yuan

et al. 2016

Sci Rep

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“…miR‐199 reportedly suppresses HCV infection by connecting with their own targets on the HCV genome . Serum miR‐199a are decreased significantly among patients with cirrhosis and HCC, indicating that miR‐199a could be used as a potential circulating biomarker for HCC …”

Section: Introductionmentioning

confidence: 99%

Serum and exosomal miR‐122 and miR‐199a as a biomarker to predict therapeutic efficacy of hepatitis C patients

Jiao

Fan

Chen

et al. 2017

Journal of Medical Virology

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MicroRNA (miRNA), which has been shown to correlate with liver functions, has been proposed as a new biomarker reflecting liver injury. The aim of the study was to investigate miRNA-122 (miR-122) and mir-RNA-199a (miR-199a) as a biomarker for predicting therapeutic efficacy in hepatitis C (HepC) patients. A total of 47 HepC 1b patients and 16 healthy subjects were enrolled in the study. Serum and exosomal mir-RNAs and other conventional biomarkers reflecting liver function were evaluated. The miR-122 levels in serum (miR-122 ) and exosomes (miR-122 ) were significantly lower in the Hepatitis C virus (HCV) genotype 1b patients than in the normal controls, but these levels were higher compared to the non-genotype 1b group. The mean miR-122 level in the sustained virological response (SVR) group was significantly higher than that in the non-response (NR) group (P < 0.01), and the miR-122 level in the SVR group was also higher than that in the NR group (P > 0.05), although this difference was not significant. miR-199a levels showed similar trends with the miR-122 levels in serum and exosomes. HCV RNA was negatively correlated with the miR-122 (r = -0.473, P = 0.004) and miR-122 (r = -0.424, P = 0.009) levels. miR-122 levels were positively associated with miR-199a levels (r = 0.453, P = 0.002) Univariate and multivariate regression analyses reveal that the miR-122 levels and ALT/AST ratio demonstrated a predictive value in evaluating patient outcomes. Serum miR-122 and miR-199a are potential biomarkers that reflect therapeutic efficacy.

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“…The molecular mechanisms include up regulation of oncogenes, inhibition of malignancy oppressor genes, up regulation of growth agents[35], stimulation of telomerase and DNA mismatch repair error may share in the development of liver carcinogenesis[20,36,37]. In this context, over expression or down expression of the studied genes which are related to cell cycle progression, growth, disease creation, and reaction to surrounding stimulants cooperate leading to this sophisticated process.…”

Section: Genetic Changes During Hcv Related Liver Carcinogenesismentioning

confidence: 99%

Insights for hepatitis C virus related hepatocellular carcinoma genetic biomarkers: Early diagnosis and therapeutic intervention

Ezzat

Amr

2016

WJH

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The current review explores the role of emerging molecular contributing factors in liver carcinogenesis on top of hepatitis C virus (HCV). Here we will try to discuss the role genetic and epigenetic factors in pathogenesis of hepatocellular carcinoma. Understanding the role of these factors will help in discovering the mystery of liver carcinogenesis on top of chronic HCV infection. Moreover, use of the studied molecular factors will provide the hepatologists with tailored diagnostic promising biomarkers and flatten the way for establishment of emerging molecular treatment based on exploring the molecular subscription of this aggressive liver cancer.

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The potential role of miRNAs 21 and 199-a in early diagnosis of hepatocellular carcinoma

Cited by 56 publications

References 35 publications

Biomarker MicroRNAs for Diagnosis, Prognosis and Treatment of Hepatocellular Carcinoma: A Functional Survey and Comparison

Biomarker MicroRNAs for Diagnosis, Prognosis and Treatment of Hepatocellular Carcinoma: A Functional Survey and Comparison

Serum and exosomal miR‐122 and miR‐199a as a biomarker to predict therapeutic efficacy of hepatitis C patients

Insights for hepatitis C virus related hepatocellular carcinoma genetic biomarkers: Early diagnosis and therapeutic intervention

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