The Potential Role of Naringin and Naringenin as Nutraceuticals Against
Metabolic Syndrome

Valencia, Débora Villaño; Massaro, Luca; Raguzzini, Anna; Aiello, Paola

doi:10.2174/1871530322666220827141203

Cited by 9 publications

(4 citation statements)

References 191 publications

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“…On the other hand, NG, a phytochemical used as an ameliorative agent against hepatoxicity through lowered oxidative stress, inflammation and apoptotic damage in various studies (Shirani et al, 2020). W e select NG among many products because it has more absorption into the body with an increase in bioavailability than naringin powder (Massaro et al, 2023). This study, therefore, evaluates the chronic effects of NG at different intervals.…”

Section: Immunoexpression Of Nf-кb and Caspaes-3mentioning

confidence: 99%

Ameliorative Effect of Naringenin in 5-Fluorouracil-Induced Hepatotoxicity: An Experimental Study on Albino Wistar Rats

Vemula,

Mylaram,

Yadala

et al. 2024

IJAR

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Background: Hepatotoxicity is an adverse complication in 5-Fluorouracil cancer treatment. Inflammation, oxidative stress, apoptosis and DNA damage are essential in the pathogenesis of liver damage. The present study evaluated the ameliorative effect of Naringenin (NG) in 5-FU at two different intervals in hepatic damage. Methods: Total (n=48) Albino Wistar rats were divided into 4 groups (N=12), Control-normal saline (group-1) per oral, 5-FU (group-2) @ 20 mg/kg b.wt was injected intraperitoneal (IP) for first 5 days, NG (group-3) @100 mg/kg b. wt/day orally for 28 days. Another group-4 was concurrently treated with NG along with 5-FU for 28 days and sacrificed on the 14th and 28th day of the experiment. Result: On exposure to 5-FU, biochemical variation of liver enzymes (ALT, AST, ALP and TP) were significantly increased while NG treatment significantly reduced these biomarkers in group 2 on 14th day and 28th day of the experiment. Furthermore, NG treatment significantly reduced lipid peroxidation and increases the antioxidant profile. It also significantly reduced elevated concentrations of pro-inflammatory cytokines like tumour necrosis factor (TNF-α), interleukin -1β (IL-1β), interleukin-6 (IL-6) with increased concentrations of interleukin-10 (IL-10) along with reduced immunohistochemical expression of nuclear factor kappa light chain enhancer of activated B cells (NF-κB) and Caspases -3 (Cas-3) by NG. On histopathology, pathological lesions were observed to support biochemical variations in group-2 rats. In group-4 rats, NG ameliorates liver enzymes, inflammatory cytokines and oxidative indices through an anti-oxidant, anti-inflammatory and anti-apoptotic property.

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Section: Immunoexpression Of Nf-кb and Caspaes-3mentioning

confidence: 99%

Ameliorative Effect of Naringenin in 5-Fluorouracil-Induced Hepatotoxicity: An Experimental Study on Albino Wistar Rats

Vemula,

Mylaram,

Yadala

et al. 2024

IJAR

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“…Consequently, naringin not only suppressed their migration and invasion capabilities but also reversed their acquired resistance to gemcitabine [ 142 ]. In TNF-α-induced VSMC, treatment with the aglycone naringenin yielded comparable outcomes to naringin [ 143 ]. These included similar levels of MMP-9 expression, invasion, migration, and AKT phosphorylation.…”

Section: Flavonoids On Cancer Metastasismentioning

confidence: 99%

Unveiling the Power of Flavonoids: A Dynamic Exploration of Their Impact on Cancer through Matrix Metalloproteinases Regulation

Rajendran

2024

BioMedicine

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Cancer stands as a significant contributor to global mortality rates, primarily driven by its progression and widespread dissemination. Despite notable strides in cancer therapy, the efficacy of current treatment strategies is compromised due to their inherent toxicity and the emergence of chemoresistance. Consequently, there is a critical need to evaluate alternative therapeutic approaches, with natural compounds emerging as promising candidates, showcasing demonstrated anticancer capabilities in various research models. This review manuscript presents a comprehensive examination of the regulatory mechanisms governing the expression of matrix metalloproteinases (MMPs) and delves into the potential therapeutic role of flavonoids as agents exhibiting specific anticancer activity against MMPs. The primary aim of this study is to elucidate the diverse functions associated with MMP production in cancer and to investigate the potential of flavonoids in modulating MMP expression to inhibit metastasis.

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“…Naringin, a natural flavanone found in citrus fruits, and its aglycone have been demonstrated to ameliorate obesity and dyslipidemia. The principal mechanisms by which these flavonoids exert their action involve upregulation of peroxisome proliferator activated receptor α and adenosine 5′-monophosphate-activated protein kinase, and the downregulation of genes involved in lipid metabolism ( Massaro et al, 2022 ). Naringin is an effective therapeutic drug for the treatment of KOA and KOA-related symptoms, which can support the recovery of hind-limb weight-bearing ( Xu et al, 2017 ).…”

Section: Discussmentioning

confidence: 99%

Clinical efficacy of Yiqi Yangxue formula on knee osteoarthritis and unraveling therapeutic mechanism through plasma metabolites in rats

et al. 2023

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Objective: To observe the clinical efficacy and safety of Yiqi Yangxue formula (YQYXF) on knee osteoarthritis (KOA), and to explore the underlying therapeutic mechanism of YQYXF through endogenous differential metabolites and their related metabolic pathways.Methods: A total of 61 KOA patients were recruited and divided into the treatment group (YQYXF, 30 cases) and the control group (celecoxib, Cxb, 31 cases). Effects of these two drugs on joint pain, swelling, erythrocyte sedimentation rate (ESR) and c-reactive protein (CRP) were observed, and their safety and adverse reactions were investigated. In animal experiments, 63 SD rats were randomly divided into normal control (NC) group, sham operation (sham) group, model (KOA) group, Cxb group, as well as low-dose (YL), medium-dose (YM), and high-dose groups of YQYXF (YH). The KOA rat model was established using a modified Hulth method. Ultra-high-performance liquid chromatography/Q Exactive HF-X Hybrid Quadrupole-Orbitrap Mass (UHPLC-QE-MS)-based metabolomics technology was used to analyze the changes of metabolites in plasma samples of rats. Comprehensive (VIP) >1 and t-test p < 0.05 conditions were used to screen the disease biomarkers of KOA, and the underlying mechanisms of YQYXF were explored through metabolic pathway enrichment analysis. The related markers of YQYXF were further verified by ELISA (enzyme-linked immunosorbent assay).Results: YQYXF can improve joint pain, swelling, range of motion, joint function, Michel Lequesen index of severity for osteoarthritis (ISOA) score, Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) score, ESR, and CRP. No apparent adverse reactions were reported. In addition, YQYXF can improve cartilage damage in KOA rats, reverse the abnormal changes of 16 different metabolites, and exert an anti-KOA effect mainly through five metabolic pathways. The levels of reactive oxygen species (ROS) and glutathione (GSH) were significantly decreased after the treatment of YQYXF.Conclusion: YQYXF can significantly improve the clinical symptoms of KOA patients without obvious adverse reactions. It mainly improved KOA through modulating lipid metabolism-related biomarkers, reducing lipid peroxidation and oxidative stress.

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The Potential Role of Naringin and Naringenin as Nutraceuticals Against Metabolic Syndrome

Cited by 9 publications

References 191 publications

Ameliorative Effect of Naringenin in 5-Fluorouracil-Induced Hepatotoxicity: An Experimental Study on Albino Wistar Rats

Ameliorative Effect of Naringenin in 5-Fluorouracil-Induced Hepatotoxicity: An Experimental Study on Albino Wistar Rats

Unveiling the Power of Flavonoids: A Dynamic Exploration of Their Impact on Cancer through Matrix Metalloproteinases Regulation

Clinical efficacy of Yiqi Yangxue formula on knee osteoarthritis and unraveling therapeutic mechanism through plasma metabolites in rats

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