The Potential Role of Seminal Plasma in the Fertilization Outcomes

Szczykutowicz, Justyna; Kałuża, Anna; Kaźmierowska-Niemczuk, Maria; Ferens-Sieczkowska, Mirosława

doi:10.1155/2019/5397804

Cited by 45 publications

(39 citation statements)

References 85 publications

(112 reference statements)

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“…The sperm membrane also acquires greater fluidity, by incorporating unsaturated fatty acids and gradually removing cholesterol and phospholipids [ 7 ]. Despite these changes occurring in the epididymal environment, sperm is still in a quiescent state by means of the acidic pH, as described above, and the “decapacitation” factors, such as the binder of sperm protein (BSP), that binds to the sperm membrane in order to protect SPZ until they reach the fallopian tube to achieve capacitation [ 63 , 64 ].…”

Section: Exosomes In the Male Reproductive Tract: Their Potential mentioning

confidence: 99%

“…Prostasomal proteins have antioxidant, antimicrobial and antibacterial properties; coagulant properties serve to prevent sperm contact with female blood, and protect SPZ against the immune response in the female reproductive tract by inhibiting monocyte and neutrophil phagocytosis [ 22 , 64 , 75 ]. Additionally, these vesicles play key roles, both inhibitory and stimulatory, in several physiological sperm functions, such as sperm motility, sperm capacitation and acrosome reaction [ 62 , 76 ].…”

Section: Exosomes In the Male Reproductive Tract: Their Potential mentioning

confidence: 99%

“…SP proteins are also involved in the regulation of sperm motility, hyperactivation and acrosomal reaction; they provide protection against oxidative processes and have immunosuppressive properties inducing an effective inhibition of lymphocytes, macrophages and the complement system [ 2 , 5 , 6 , 10 , 22 , 64 , 91 , 92 , 93 ]. SP has the additional advantage that it is usually obtained in large amounts, providing a good source for proteomic analysis.…”

Section: Proteomic Landscape Of Sp: a Potential Indicator Of Spermmentioning

confidence: 99%

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Exosome Composition and Seminal Plasma Proteome: A Promising Source of Biomarkers of Male Infertility

Candenas

Chianese

2020

IJMS

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Infertility has become a global health issue, with approximately 50% of infertility cases generated by disorders in male reproduction. Spermatozoa are conveyed towards female genital tracts in a safe surrounding provided by the seminal plasma. Interestingly, this dynamically changing medium is a rich source of proteins, essential not only for sperm transport, but also for its protection and maturation. Most of the seminal proteins are acquired by spermatozoa in transit through exosomes (epididymosomes and prostasomes). The high number of seminal proteins, the increasing knowledge of their origins and biological functions and their differential expression in the case of azoospermia, asthenozoospermia, oligozoospermia and teratozoospermia or other conditions of male infertility have allowed the identification of a wide variety of biomarker candidates and their involvement in biological pathways, thus to strongly suggest that the proteomic landscape of seminal plasma may be a potential indicator of sperm dysfunction. This review summarizes the current knowledge in seminal plasma proteomics and its potentiality as a diagnostic tool in different degrees of male infertility.

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Section: Exosomes In the Male Reproductive Tract: Their Potential mentioning

confidence: 99%

Section: Exosomes In the Male Reproductive Tract: Their Potential mentioning

confidence: 99%

Section: Proteomic Landscape Of Sp: a Potential Indicator Of Spermmentioning

confidence: 99%

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Exosome Composition and Seminal Plasma Proteome: A Promising Source of Biomarkers of Male Infertility

Candenas

Chianese

2020

IJMS

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“…This altered glycosylation profile would be more implicated with inhibition of the adaptive immune system and less so with inhibition of the innate immune response [146]. The presence of immunosuppressive glycans on sperm and in seminal plasma might function in improving fertilization outcomes [147].…”

Section: Glycosylation In Pregnancy Term and Preterm Labormentioning

confidence: 99%

Role of galectin-glycan circuits in reproduction: from healthy pregnancy to preterm birth (PTB)

Blois

Verlohren

et al. 2020

Semin Immunopathol

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Growing evidence suggests that galectins, an evolutionarily conserved family of glycan-binding proteins, fulfill key roles in pregnancy including blastocyst implantation, maternal-fetal immune tolerance, placental development, and maternal vascular expansion, thereby establishing a healthy environment for the growing fetus. In this review, we comprehensively present the function of galectins in shaping cellular circuits that characterize a healthy pregnancy. We describe the current understanding of galectins in term and preterm labor and discuss how the galectin-glycan circuits contribute to key immunological pathways sustaining maternal tolerance and preventing microbial infections. A deeper understanding of the glycoimmune pathways regulating early events in preterm birth could offer the broader translational potential for the treatment of this devastating syndrome.

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“…These SP proteins and peptides play a key role in regulating both sperm function, i.e., fertilizing ability, and even the uterine immune environment once deposited into the female genital tract [4][5][6]. Consequently, the SP proteome is currently being explored for potential biomarkers of male (in)fertility [7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Period of Boar Ejaculate Collection Contributes to the Yearly Intra-Male Variability of Seminal Plasma Cytokines

Padilla

Lucas

Parrilla

et al. 2020

Biology

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The concentrations of cytokines in seminal plasma (SP) fluctuate over time in healthy males, weakening their practical usefulness as diagnostic tools. This study evaluated the relevance of intra-male variability in SP cytokines and to what extent the period of the year when ejaculate is collected contributes to such variability. Thirteen cytokines (GM-CSF, IFNγ, IL-1α, IL-1β, IL-1ra, IL-2, IL-4, IL-6, IL-8, IL-10, IL-12, IL-18, and TNFα) were measured using the Luminex xMAP® technology for 180 SP samples of ejaculate collected over a year from nine healthy and fertile boars. The SP samples were grouped into two annual periods according to decreasing or increasing daylight and ambient temperature. Intra-male variability was higher than inter-male variability for all cytokines. All SP cytokines showed concentration differences between the two periods of the year, showing the highest concentration during the increasing daylength/temperature period, irrespective of the male. Similarly, some cytokines showed differences between daylength/temperature periods when focusing on their total amount in the ejaculate. No strong relationship (explaining more than 50% of the total variance) was found between annual fluctuations in SP-cytokine levels and semen parameters. In conclusion, the period of the year during which ejaculates were collected helps explain the intra-male variability of SP-cytokine levels in breeding boars.

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The Potential Role of Seminal Plasma in the Fertilization Outcomes

Cited by 45 publications

References 85 publications

Exosome Composition and Seminal Plasma Proteome: A Promising Source of Biomarkers of Male Infertility

Exosome Composition and Seminal Plasma Proteome: A Promising Source of Biomarkers of Male Infertility

Role of galectin-glycan circuits in reproduction: from healthy pregnancy to preterm birth (PTB)

Period of Boar Ejaculate Collection Contributes to the Yearly Intra-Male Variability of Seminal Plasma Cytokines

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