The potential role of serum angiotensin-converting enzyme in the coronavirus disease 2019

Zhu, Zhe; Cai, Ting; Fan, Limin; Lou, Kehong; Hua, Xin; Huang, Zuoan; Gao, Guosheng

doi:10.21203/rs.3.rs-35018/v1

Cited by 8 publications

(15 citation statements)

References 26 publications

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“…5 Schematic outline of low serum ACE level in relation to inflammation, immune status, and clinical outcome normal level with disease remission. In that study, although the lowest ACE level was noted in the group with more severe infection, baseline ACE failed to serve as an independent risk factor for disease severity of COVID-19 [8]. To the best of our knowledge, this is the first investigation into whether, and to what extent, a relationship exists between ACE level and COVID-19 disease progression.…”

Section: Discussionmentioning

confidence: 80%

“…It has been indicated in recent years that serum ACE level correlates with the diagnosis and prognosis of a variety of respiratory disorders [7]; however, the potential relationship between ACE level and clinical outcomes of SARS-CoV-2 infection is not adequately understood. The latest research based on 136 patients with confirmed COVID-19 suggested that serum ACE level could serve as a marker to reflect the clinical condition of COVID-19 rather than an independent risk factor for disease severity [8]. In our study, 120 patients with confirmed COVID-19 who underwent measurement of serum ACE levels on admission were retrospectively enrolled, to evaluate the potential role of serum ACE level in combination with other risk factors in predicting disease progression of COVID-19 and further investigate the possible mechanisms involved.…”

Section: Introductionmentioning

confidence: 99%

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Lower Serum Angiotensin-Converting Enzyme Level in Relation to Hyperinflammation and Impaired Antiviral Immune Response Contributes to Progression of COVID-19 Infection

et al. 2021

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Introduction: As a homologue of the angiotensin-converting enzyme (ACE), angiotensinconverting enzyme 2 (ACE2) has been identified as the main receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) invasion. We aimed to investigate the role of serum ACE in predicting the coronavirus disease 2019 (COVID-19) disease progression and the underlying mechanisms. Methods: We retrospectively enrolled 120 patients with confirmed COVID-19 who underwent serum ACE detection on admission.The clinical characteristics and laboratory findings during hospitalization were evaluated dynamically to identify the potential risk factors for disease progression.Results: ACE level was demonstrated as one of the independent risk factors. Patients with ACE level B 33.5 U/L showed a higher cumulative virus RNA detection rate, elevated pro-inflammatory mediators levels, declined lymphocyte count, and decreased SARS-CoV-2-specific antibodies than those with ACE level [ 33.5 U/L. Conclusion: Lower serum ACE levels in relation to delayed virus elimination, hyperinflammatory condition, and impaired host antiviral immune responses contribute to disease progression of COVID-19.

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Section: Discussionmentioning

confidence: 80%

Section: Introductionmentioning

confidence: 99%

Lower Serum Angiotensin-Converting Enzyme Level in Relation to Hyperinflammation and Impaired Antiviral Immune Response Contributes to Progression of COVID-19 Infection

et al. 2021

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“…The meta-analysis that we carried out in the previous section has shed some light on these questions to a certain extent, but many points remain obscure. Indeed, the experimental and clinical data that we collected from the literature about e.g., the levels of proteins and peptides involved in RAS and the activity of the enzymes, partially disagree [77,78,79,80,81,82,83,84,85,86,87,88,89,90,91,92].…”

Section: Discussionmentioning

confidence: 99%

“…We review here recent data about measurements of RAS components in COVID-19. For that purpose, we manually collected and screened a series of clinical and experimental results from [77,78,79,80,81,82,83,84,85,86,87,88,89,90,91,92], listed in Supplementary Table S1. The individuals enrolled in these studies were classified into two or three classes: COVID-19 patients or severe and moderate COVID-19 patients, and controls or asymptomatic patients.…”

Section: Meta-analysis On Ras Components In Covid-19mentioning

confidence: 99%

Quantifying renin-angiotensin-system alterations in COVID-19

Pucci

Annoni

Santos

et al. 2021

Preprint

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The renin-angiotensin system (RAS) plays a pivotal role in a wide series of physiological processes. One of its key components, the angiotensin-converting enzyme 2, has been identified as the entry point of the SARS-CoV-2 virus into the host cells, so many studies have been devoted to study RAS dysregulation in COVID-19. Here we discuss the alterations of the regulatory RAS axes due to SARS-CoV-2 infection on the basis of a series of recent clinical and experimental analyzes, which, for example, quantify the levels and activity of RAS components, in order to disentangle the links between the impaired RAS functioning and the pathophysiological characteristics of COVID-19. Finally, we discussed the effects of some RAS-targeting drugs, and how they could potentially contribute to restore the normal RAS functionality and minimize COVID-19 severity.

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“…Immune-inflammatory disorders can be associated with ACE/ACE2 [41]. The role of ACE2 in SARS-CoV-2 infection stands itself as an irony.…”

Section: Angiotensin-converting Enzyme (Ace)-dependent Pathwaymentioning

confidence: 99%

COVID-19 and Rheumatoid Arthritis Crosstalk: Emerging association, therapeutic options, and challenges

Kandimalla¹,

Dewanjee²,

Kalra³

et al. 2021

Preprint

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Excessive immune activation and cytokine release in alveoli/lung structures is a prominent sign of coronavirus disease 2019 (COVID-19) pathology caused by infectious severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The progressive sign of pro-inflammatory cytokines elicited in COVID-19 clinically resembles hyper immune-reactive features often seen in rheumatoid arthritis (RA), an autoimmune disorder. Recent clinical data from the ongoing COVID-19 pandemic conferred the severity and risk of COVID-19 to RA patients. Amid the evidence of musculoskeletal manifestations involving immune-inflammation-dependent mechanisms and cases of arthralgia and/or myalgia in COVID-19, crosstalk between COVID-19 and RA is debated. The present review sheds light on the overlapping COVID-19 and RA clinical features, aspects of SARS-CoV-2 infection in RA development, and associated risks. It also confers whether RA can worsen COVID-19 outcomes based on available clinical readouts. To gain mechanistic insights into the overlapping immune-inflammatory features in SARS-CoV-2 infection and RA, we reviewed the emerging links of angiotensin-converting enzyme (ACE)-dependent and macrophage-mediated pathways. Moreover, a detailed review of immediate challenges and key recommendations for anti-rheumatic drugs in the COVID-19 setting was presented for better clinical monitoring and management of RA patients. Taken together, present review summarizes available knowledge on the emerging COVID-19 and RA crosstalk and their mechanistic overlaps, challenges, and therapeutic options.

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The potential role of serum angiotensin-converting enzyme in the coronavirus disease 2019

Cited by 8 publications

References 26 publications

Lower Serum Angiotensin-Converting Enzyme Level in Relation to Hyperinflammation and Impaired Antiviral Immune Response Contributes to Progression of COVID-19 Infection

Lower Serum Angiotensin-Converting Enzyme Level in Relation to Hyperinflammation and Impaired Antiviral Immune Response Contributes to Progression of COVID-19 Infection

Quantifying renin-angiotensin-system alterations in COVID-19

COVID-19 and Rheumatoid Arthritis Crosstalk: Emerging association, therapeutic options, and challenges

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