The potential role of vitamin D for prevention and treatment of tuberculosis and infectious diseases

Dini, Carlotta Sorini; Bianchi, Antonio

doi:10.4415/ann_12_03_13

Cited by 50 publications

(34 citation statements)

References 85 publications

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“…In recent years, vitamin D deficiency in humans has received significant attention [7], [51], [52]. It has been shown to play a potent role in the susceptibility to respiratory infectious diseases [53], [54]. A still unresolved question arising from ongoing laboratory and clinical research is the serum vitamin D concentrations needed to elicit an optimal immune response [55].…”

Section: Discussionmentioning

confidence: 99%

Vitamin D Deficiency Causes Defective Resistance to Aspergillus fumigatus in Mice via Aggravated and Sustained Inflammation

Cao

et al. 2014

PLoS ONE

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BackgroundVitamin D plays an important role in pulmonary resistance and immunity, and its deficiency has been linked to various respiratory infections. Little is known about the effect of vitamin D deficiency on host pulmonary defense to Aspergillus fumigatus (A. fumigatus).MethodsMice raised on vitamin D sufficient or deficient diets were infected intratracheally with A. fumigatus conidia. Mortality, fungal growth, weight loss and lung histology were monitored. Alveolar macrophages (AMs) were stimulated with A. fumigatus conidia in vitro. The kinetics of pro-inflammatory cytokines (TNF-α, IL-1β and IL-6), chemokines (CXCL1, CCL3), and pattern recognition receptors (Toll-like receptor [TLR] 2, TLR 4 and dectin-1) expression in the lungs and AMs were measured.ResultsUpon A. fumigatus infection, vitamin D deficient mice showed higher mortality, greater fungal load, and more weight loss than its sufficient counterparts. Vitamin D deficient mice demonstrated aggravated and prolonged histological evidence of lung inflammation as well as enhanced BAL cell counts, dominated by neutrophils after A. fumigatus inoculation. Increased basal levels of pro-inflammatory cytokines in the lungs and AMs from naïve vitamin D deficient mice were observed. Upon A. fumigatus exposure, vitamin D deficiency led to enhanced and sustained expression of TNF-α, IL-1β, IL-6, CXCL1 and CCL3 both in vivo and in vitro. Up-regulation of TLR2, TLR4 and dectin-1was observed in the lungs and AMs from vitamin D deficient mice both at baseline and after A. fumigatus exposure.ConclusionsVitamin D deficiency causes defective pulmonary resistance to A. fumigatus in mice, possibly by the enhanced basal expression of pattern recognition receptors and pro-inflammatory cytokines, which induced excessive inflammatory response in response to A. fumigatus challenge.

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Section: Discussionmentioning

confidence: 99%

Vitamin D Deficiency Causes Defective Resistance to Aspergillus fumigatus in Mice via Aggravated and Sustained Inflammation

Cao

et al. 2014

PLoS ONE

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“…Calcitriol activation of VDRs induces cathelicidin antimicrobial peptide (CAMP) gene expression and subsequently production of cathelicidin [11]. This important antimicrobial peptide, cathelicidin, disrupts the bacterial cell membrane [12] and induces autophagy in monocytes, creating an antimicrobial effect (FIGURE 1) [13][14][15]. Of note, this vitamin D-directed antimicrobial action does not occur in the absence of cathelicidin; instead, enhanced intracellular mycobacterial growth takes place [16].…”

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confidence: 91%

Vitamin D supplementation: a comprehensive review on supplementation for tuberculosis prophylaxis

Turnbull¹,

Drobniewski

2015

Expert Review of Respiratory Medicine

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Vitamin D plays a large role in the innate immune response against Mycobacterium tuberculosis (MTB) infection, activation and progression. Likewise, vitamin D deficiency is shown by evidence presented here to be a known risk factor for developing both MTB infection and active tuberculosis (TB). This comprehensive review discusses the evidence and remaining questions regarding vitamin D supplementation as a prophylactic measure in those who are at high risk of MTB infection and active TB. Vitamin D supplementation is routinely prescribed for osteoporosis prevention; yet, guidelines are lacking for its prescription for TB prevention, despite the adverse effects being rare. Policymakers are urged here to review the literature and provide urgent guidelines on vitamin D supplementation for TB prophylaxis.

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“…Vitamins have been found to regulate immunity, and a number of studies have reported the effect of vitamins as adjunct to treat tuberculosis (Parida et al, 2015;He et al, 2018). For example, vitamins A, C and D have been used as adjunct to complement anti-tuberculosis drugs (Dini and Bianchi, 2012;Vilcheze et al, 2013;Syal et al, 2015). The active form of thiamin (Vitamin B1, V B1 ), thiamin diphosphate (ThDP) (Begley et al, 1999;Settembre et al, 2003;Pohl et al, 2004), is an essential cofactor in all organisms, taking an important role in energy metabolism and degradation of sugars.…”

Section: Introductionmentioning

confidence: 99%

Vitamin B and Vitamin C Affect DNA Methylation and Amino Acid Metabolism in Mycobacterium bovis BCG

et al. 2020

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Vitamins are essential nutrients and key cofactors of enzymes that regulate cellular metabolism, and also activate the immune system. Recent studies have shown that vitamin B1 (V B1 ) and vitamin C (Vc) can inhibit Mycobacterium tuberculosis growth, but the precise mechanism is still not well understood. In the present study, we have used RNA-sequencing (RNA-seq), liquid chromatography coupled to mass spectrometry (LC-MS) and single-molecule real-time (SMRT) sequencing to analyze the transcriptional, metabolic and methylation profiles of Mycobacterium bovis BCG when treated with V B1 and Vc. Our results show that, after vitamin treatment, variant metabolites were mainly clustered in pathways related to amino acid metabolism. Treatment with both vitamins significantly up-regulated the gene encoding cysteine synthase A. Additionally, only BCG that was treated with V C showed m4c modifications. Genes harboring this methylation were up-regulated, suggesting that m4c methylation can promote gene transcription to some extent. Overall, this study contributes to the understanding of the effects of V B1 and V C , and suggests that these vitamins constitute potential anti-tuberculosis drugs.

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The potential role of vitamin D for prevention and treatment of tuberculosis and infectious diseases

Cited by 50 publications

References 85 publications

Vitamin D Deficiency Causes Defective Resistance to Aspergillus fumigatus in Mice via Aggravated and Sustained Inflammation

Vitamin D Deficiency Causes Defective Resistance to Aspergillus fumigatus in Mice via Aggravated and Sustained Inflammation

Vitamin D supplementation: a comprehensive review on supplementation for tuberculosis prophylaxis

Vitamin B and Vitamin C Affect DNA Methylation and Amino Acid Metabolism in Mycobacterium bovis BCG

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