“…4-NP and 4-t-OP are both endocrine disruptors, which are able to mimic natural hormones and interact with estrogen receptor (Lee and Lee, 1996), posing harmful influences, including feminization and carcinogenesis, on several aquatic species (Schwaiger et al, 2002;Capaldo et al, 2012;Chen and Yen, 2013). Many researchers have shown that 4-NP and 4-t-OP widely exist in various mediums of water environment, such as water, sediments and biological bodies (Jonkers et al, 2005;Soares et al, 2008;Wang et al, 2010;Duan et al, 2014;Cheng et al, 2006a,b;Li et al, 2008;Lee et al, 2013), especially the sediments, which play the role of storing AP. According to some studies (David et al, 2009;Wang et al, 2010), the 4-NP and 4-t-OP contents of marine sediments are about 2.2-20 700 and 1.9-179 ng g À1 , respectively; the concentration of 4-NP is apparently higher than that of 4-t-OP, and is about 500 times the PNEC value (39 ng g À1 , predicted no effect concentration) (European Commission, 2002).…”