The Potential Roles of RNA N6-Methyladenosine in Urological Tumors

Yang, Li; Ge, Yu‐Zheng; Xu, Luwei; Xu, Zheng; Dou, Qingyu; Jia, Ru

doi:10.3389/fcell.2020.579919

Cited by 18 publications

(13 citation statements)

References 145 publications

(166 reference statements)

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“…We also explored the correlation between DNA alterations and the MCM complex, but we found that the frequency of DNA alterations was not high, and it was unlikely that DNA alterations led to dysregulation of the MCM complex. Non-coding RNA is a clear example of how inherited epigenetic changes can play a role in carcinogenesis, and non-coding RNA is the most abundant type of RNA ( 47 ). Therefore, we detected the potential regulatory association among miRNAs and the MCM complex.…”

Section: Discussionmentioning

confidence: 99%

Systemic Analysis of the DNA Replication Regulator MCM Complex in Ovarian Cancer and Its Prognostic Value

Zou

Zhang

et al. 2021

Front. Oncol.

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Microliposome maintenance (MCM) 2, MCM3, MCM4, MCM5, MCM6, and MCM7 are DNA replication regulators and are involved in the progression of multiple cancer types, but their role in ovarian cancer is still unclear. The purpose of this study is to clarify the biological function and prognostic value of the MCM complex in ovarian cancer (OS) progression. We analyzed DNA alterations, mRNA and protein levels, protein structure, PPI network, functional enrichment, and prognostic value in OC based on the Oncomine, cBioPortal, TCGA, CPTAC, PDB, GeneMANIA, DAVID, KEGG, and GSCALite databases. The results indicated that the protein levels of these DNA replication regulators were increased significantly. Moreover, survival analysis showed a prognostic signature based on the MCM complex, which performed moderately well in terms of OS prognostic prediction. Additionally, protein structure, functional enrichment, and PPI network analyses indicated that the MCM complex synergistically promoted OC progression by accelerating DNA replication and the cell cycle. In conclusion, our study suggested that the MCM complex might be a potential target and prognostic marker for OC patients.

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Section: Discussionmentioning

confidence: 99%

Systemic Analysis of the DNA Replication Regulator MCM Complex in Ovarian Cancer and Its Prognostic Value

Zou

Zhang

et al. 2021

Front. Oncol.

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“…A total of 22 m6A regulators were collected from relevant studies ( Li et al, 2020a ; Yi et al, 2020 ; Zheng et al, 2021 ); the regulators included 7 “writers” (WTAP, METTL16, VIRMA, RBM15B, METTL3, RBM15, and ZC3H13), 13 “readers” (YTHDC1, YTHDF1, YTHDC2, YTHDF3, IGF2BP2, LRPPRC, YTHDF2, HNRNPA2B1, HNRNPC, RBMX, EIF3A, G3BP1 and FXR1), and 2 “erasers” (ALKBH5 and FTO). The prognostic role of the m6A regulators was assessed using the Kaplan-Meier (KM) diagrams and Cox proportional hazards model.…”

Section: Methodsmentioning

confidence: 99%

Analysis of N6-Methyladenosine Modification Patterns and Tumor Immune Microenvironment in Pancreatic Adenocarcinoma

Liu

Yang

et al. 2022

Front. Genet.

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Background: Pancreatic adenocarcinoma (PAAD) is a rare cancer with a poor prognosis. N6-methyladenosine (m6A) is the most common mRNA modification. However, little is known about the relationship between m6A modification and the tumor immune microenvironment (TIME) in PAAD.Methods: Based on 22 m6A regulators, m6A modification patterns of PAAD samples extracted from public databases were systematically evaluated and correlated with the tumor immune and prognosis characteristics. An integrated model called the “m6Ascore” was constructed, and its prognostic role was evaluated.Results: Three different m6Aclusters and gene clusters were successively identified; these clusters were characterized by differences in prognosis, immune cell infiltration, and pathway signatures. The m6Ascore was constructed to quantify the m6A modifications of individual patients. Subsequent analysis revealed that m6Ascore was an independent prognostic factor of PAAD and could be a potential indicator to predict the response to immunotherapy.Conclusion: This study comprehensively evaluated the features of m6A modification patterns in PAAD. m6A modification patterns play a non-negligible role in the TIME of PAAD. m6Ascore provides a more holistic understanding of m6A modification in PAAD, and will help clinicians predict the prognosis and response to immunotherapy.

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“…In contrast with DNA modifications, which are known to mainly regulate gene expression [ 136 ], RNA modifications control many functions apart from transcription such as RNA stability, location, splicing, degradation or translation efficiency [ 134 , 137 , 138 ]. For instance, 5-methylcytosine (m 5 C) methylation of tRNAs stabilises their structure and protects them from nuclease-mediated cleavage [ 137 ].…”

Section: Epitranscriptomics Alterations In Prostate Cancermentioning

confidence: 99%

Epigenetic and Epitranscriptomic Control in Prostate Cancer

López

Añazco-Guenkova

Monteagudo-García

et al. 2022

Genes

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The initiation of prostate cancer has been long associated with DNA copy-number alterations, the loss of specific chromosomal regions and gene fusions, and driver mutations, especially those of the Androgen Receptor. Non-mutational events, particularly DNA and RNA epigenetic dysregulation, are emerging as key players in tumorigenesis. In this review we summarize the molecular changes linked to epigenetic and epitranscriptomic dysregulation in prostate cancer and the role that alterations to DNA and RNA modifications play in the initiation and progression of prostate cancer.

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The Potential Roles of RNA N6-Methyladenosine in Urological Tumors

Cited by 18 publications

References 145 publications

Systemic Analysis of the DNA Replication Regulator MCM Complex in Ovarian Cancer and Its Prognostic Value

Systemic Analysis of the DNA Replication Regulator MCM Complex in Ovarian Cancer and Its Prognostic Value

Analysis of N6-Methyladenosine Modification Patterns and Tumor Immune Microenvironment in Pancreatic Adenocarcinoma

Epigenetic and Epitranscriptomic Control in Prostate Cancer

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