The potential roles of Th17 cells in the pathogenesis of oral lichen planus

Afzali, Shima; Mohammadisoleimani, Elham; Mansoori, Yaser; Mohaghegh, Poopak; Bahmanyar, Maryam; Mansoori, Behnam; Pezeshki, Babak; Nikfar, Ghasem; Tavassoli, Alireza; Shahi, Abbas; Moravej, Ali

doi:10.1007/s00011-023-01763-7

Cited by 9 publications

(4 citation statements)

References 62 publications

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“… 6 Given the critical role of the IL-17/IL-23 axis and T helper 17 cells in numerous cutaneous and oral mucosal inflammatory conditions, we hypothesized that deucravacitinib should also be effective for OLP. 2 , 8 , 9 , 10 …”

Section: Discussionmentioning

confidence: 99%

Treatment of oral lichen planus using deucravacitinib

Vu,

Abdin,

Issa

2024

JAAD Case Reports

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Section: Discussionmentioning

confidence: 99%

Treatment of oral lichen planus using deucravacitinib

Vu,

Abdin,

Issa

2024

JAAD Case Reports

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“…OLP is related to autoimmune function, conventional T-cell subsets like CD4 + helper T (Th) cells and CD8 + cytotoxic T cells in ltrated by in ammation have garnered much attention [4,5]. Th1, Th2 cells, and Th17 are also well-accepted to be associated with OLP pathogenesis [3]. But much less is known about the roles of non-conventional T-cell subsets in the OLP process, particularly with regard to the potential in uence of innate-like lymphoid cells.…”

Section: Introductionmentioning

confidence: 99%

“…Oral lichen planus (OLP) is a common T cell-mediated in ammatory disease of the oral mucosa, with a global prevalence of 0.5-4% [1,2]. Clinically, OLP can occur at any site within the oral cavity and often manifests as in amed ulcerations with a white lace or linear patterns in a predominantly bilateral and symmetrical distribution [3]. Due to the chronic and prolonged course of the disease as well as the possibility of long-term erosion lesions leading to cancerous changes, WHO lists OLP as a precancerous state [2].…”

Section: Introductionmentioning

confidence: 99%

“…However, OLP often exhibits heterogeneous and prolonged disease course clinically. It is believed that the immune function disorders exist according to OLP evolution [3,17]. Despite this, there is still a lack of research on whether the frequency, phenotype, and function of circulating MAIT cells in OLP patients change during OLP evolution.…”

Section: Introductionmentioning

confidence: 99%

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Mucosal‐associated invariant T cell alterations in adults with recent-onset and long-term oral lichen planus

Wu,

Chen,

Yang

et al. 2024

Preprint

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Objectives Mucosal-associated invariant T (MAIT) cells play key roles in many immune-inflammatory diseases. However, their characteristics between the long-term course of oral lichen planus (OLP) and recent-onset OLP remains unknown. In this study, we aimed to investigate the function of MAIT cells in different process of OLP and to explore the immunological background of this disease. Methods The frequency, phenotype, cytokine secretion of MAIT cells and its clinical relevance by flow cytometry from the peripheral blood of 14 adults with recent-onset OLP (7-120 days after disease onset) and 16 adults with long-term course (>2 years after diagnosis) compared with 15 healthy blood donors. Statistical analyses were performed using the GraphPad Prism software. Results MAIT cells from adults with recent-onset OLP harbored an activated phenotype, as indicated by an increased frequency of CD69+ (p < 0.05) and CD38+MAIT cells (p < 0.01) and elevated production of proinflammatory cytokines IL-17A (p < 0.01), compared with healthy adult donors. In adults with long-term OLP, MAIT cells exhibit an activated and exhausted phenotype, characterized by high expression of CD69 (p < 0.01) and PD-1 (p < 0.001), as well as increased production of the granzyme B released by MAIT cells (p < 0.01). Compared with recent-onset OLP patients, long-term OLP patients show a decrease in the production of CD8+, and CD4−CD8− cells but an increase in PD-1+ production (p < 0.05). Conclusions The frequency, phenotype, and function of MAIT cells are more altered in adult OLP patients with long-term onset than in those with recent-onset OLP. Clinical Relevance With the prolonged course of OLP, MAIT cells play different functional roles.

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