The potential significance of vitamin D binding protein polymorphism in COVID-19

Speeckaert, Marijn M.; Delanghe, Joris

doi:10.1016/j.ijid.2021.06.044

Cited by 3 publications

(1 citation statement)

References 9 publications

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“…Interferon-induced GTP-binding protein Mx1 (MX1)) as well as inter-alpha-trypsin inhibitor family (ITIH) proteins, known acute phase proteins that are upregulated during inflammation [ 18 ]. Also other inflammatory proteins were more abundant in COVID-19 lungs, including different isoforms of alpha-1-acid glycoprotein [ 19 ] as well as vitamin D binding protein (GC), which not only transports vitamin D but also acts as immune system activator [ 20 , 21 ]. In addition, we report a prominent upregulation of proteins active in blood clot formation, including prothrombin (F2), coagulation factor XII (F12), antithrombin-III (SERPINC1), plasminogen (PLG) and others (Additional file 3 : Table S2).…”

Section: Resultsmentioning

confidence: 99%

Proteomic profiling of end-stage COVID-19 lung biopsies

et al. 2022

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The outbreak of a novel coronavirus (SARS-CoV-2) in 2019 led to a worldwide pandemic, which remains an integral part of our lives to this day. Coronavirus disease (COVID-19) is a flu like condition, often accompanied by high fever and respiratory distress. In some cases, conjointly with other co-morbidities, COVID-19 can become severe, leading to lung arrest and even death. Although well-known from a clinical standpoint, the mechanistic understanding of lethal COVID-19 is still rudimentary. Studying the pathology and changes on a molecular level associated with the resulting COVID-19 disease is impeded by the highly infectious nature of the virus and the concomitant sampling challenges. We were able to procure COVID-19 post-mortem lung tissue specimens by our collaboration with the BSL-3 laboratory of the Biobanking and BioMolecular resources Research Infrastructure Austria which we subjected to state-of-the-art quantitative proteomic analysis to better understand the pulmonary manifestations of lethal COVID-19. Lung tissue samples from age-matched non-COVID-19 patients who died within the same period were used as controls. Samples were subjected to parallel accumulation–serial fragmentation combined with data-independent acquisition (diaPASEF) on a timsTOF Pro and obtained raw data was processed using DIA-NN software. Here we report that terminal COVID-19 patients display an increase in inflammation, acute immune response and blood clot formation (with concomitant triggering of fibrinolysis). Furthermore, we describe that COVID-19 diseased lungs undergo severe extracellular matrix restructuring, which was corroborated on the histopathological level. However, although undergoing an injury, diseased lungs seem to have impaired proliferative and tissue repair signalling, with several key kinase-mediated signalling pathways being less active. This might provide a mechanistic link to post-acute sequelae of COVID-19 (PASC; “Long COVID”). Overall, we emphasize the importance of histopathological patient stratification when interpreting molecular COVID-19 data.

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Section: Resultsmentioning

confidence: 99%

Proteomic profiling of end-stage COVID-19 lung biopsies

et al. 2022

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Association of CYP24A1 Gene rs6127099 (A > T) Polymorphism with Lower Risk to COVID-19 Infection in Kazakhstan

Sarría‐Santamera

Mukhtarova

Baizhaxynova

et al. 2023

Genes

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In December 2019, SARS-CoV-2 was identified in Wuhan, China. Infection by SARS-CoV-2 causes coronavirus disease 2019 (COVID-19), which is characterized by fever, cough, dyspnea, anosmia, and myalgia in many cases. There are discussions about the association of vitamin D levels with COVID-19 severity. However, views are conflicting. The aim of the study was to examine associations of vitamin D metabolism pathway gene polymorphisms with symptomless COVID-19 susceptibility in Kazakhstan. The case-control study examined the association between asymptomatic COVID-19 and vitamin D metabolism pathway gene polymorphisms in 185 participants, who previously reported not having COVID-19, were PCR negative at the moment of data collection, and were not vaccinated. A dominant mutation in rs6127099 (CYP24A1) was found to be protective of asymptomatic COVID-19. Additionally, the G allele of rs731236 TaqI (VDR), dominant mutation in rs10877012 (CYP27B1), recessive rs1544410 BsmI (VDR), and rs7041 (GC) are worth consideration since they were statistically significant in bivariate analysis, although their independent effect was not found in the adjusted multivariate logistic regression model.

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Role of Vitamin D in COVID-19: Correspondence

Sookaromdee¹,

Wiwanitkit

2022

Indian J Pharmacol

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The potential significance of vitamin D binding protein polymorphism in COVID-19

Cited by 3 publications

References 9 publications

Proteomic profiling of end-stage COVID-19 lung biopsies

Proteomic profiling of end-stage COVID-19 lung biopsies

Association of CYP24A1 Gene rs6127099 (A > T) Polymorphism with Lower Risk to COVID-19 Infection in Kazakhstan

Role of Vitamin D in COVID-19: Correspondence

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