The potential use of nanozyme in aging and age‐related diseases

Gorgzadeh, Amirsasan; Amiri, Paria Arab; Yasamineh, Saman; Naser, Basim Kareem; abdulallah, Khairia abdulrahman

doi:10.1007/s10522-024-10095-w

Cited by 5 publications

(1 citation statement)

References 109 publications

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“…Furthermore, considering the ligands of NZs may affect systemic toxicity, clearance kinetics, bioavailability, and therapeutic results. According to this viewpoint, it's crucial to choose a suitable ligand and provide NZs with more biosafety [ 9 , 147 ].…”

Section: Future and Landscape Of Antibacterial Nanozymes In Dental Di...mentioning

confidence: 99%

The potential use of nanozymes as an antibacterial agents in oral infection, periodontitis, and peri-implantitis

Hosseini Hooshiar,

Badkoobeh,

Kolahdouz

et al. 2024

J Nanobiotechnol

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Several studies suggest that oral pathogenic biofilms cause persistent oral infections. Among these is periodontitis, a prevalent condition brought on by plaque biofilm. It can even result in tooth loss. Furthermore, the accumulation of germs around a dental implant may lead to peri-implantitis, which damages the surrounding bone and gum tissue. Furthermore, bacterial biofilm contamination on the implant causes soft tissue irritation and adjacent bone resorption, severely compromising dental health. On decontaminated implant surfaces, however, re-osseointegration cannot be induced by standard biofilm removal techniques such as mechanical cleaning and antiseptic treatment. A family of nanoparticles known as nanozymes (NZs) comprise highly catalytically active multivalent metal components. The most often employed NZs with antibacterial activity are those that have peroxidase (POD) activity, among other types of NZs. Since NZs are less expensive, more easily produced, and more stable than natural enzymes, they hold great promise for use in various applications, including treating microbial infections. NZs have significantly contributed to studying implant success rates and periodontal health maintenance in periodontics and implantology. An extensive analysis of the research on various NZs and their applications in managing oral health conditions, including dental caries, dental pulp disorders, oral ulcers, peri-implantitis, and bacterial infections of the mouth. To combat bacteria, this review concentrates on NZs that imitate the activity of enzymes in implantology and periodontology. With a view to the future, there are several ways that NZs might be used to treat dental disorders antibacterially. Graphical Abstract

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Section: Future and Landscape Of Antibacterial Nanozymes In Dental Di...mentioning

confidence: 99%

The potential use of nanozymes as an antibacterial agents in oral infection, periodontitis, and peri-implantitis

Hosseini Hooshiar,

Badkoobeh,

Kolahdouz

et al. 2024

J Nanobiotechnol

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Recent advances in nanomaterial-based biosensor for periodontitis detection

Hooshiar,

Moghaddam,

Kiarashi

et al. 2024

J Biol Eng

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Periodontitis, a chronic inflammatory condition caused by bacteria, often causes gradual destruction of the components that support teeth, such as the alveolar bone, cementum, periodontal ligament, and gingiva. This ultimately results in teeth becoming loose and eventually falling out. Timely identification has a crucial role in preventing and controlling its progression. Clinical measures are used to diagnose periodontitis. However, now, there is a hunt for alternative diagnostic and monitoring methods due to the progress of technology. Various biomarkers have been assessed using multiple bodily fluids as sample sources. Furthermore, conventional periodontal categorization factors do not provide significant insights into the present disease activity, severity and amount of tissue damage, future development, and responsiveness to treatment. In recent times, there has been a growing utilization of nanoparticle (NP)-based detection strategies to create quick and efficient detection assays. Every single one of these platforms leverages the distinct characteristics of NPs to identify periodontitis. Plasmonic NPs include metal NPs, quantum dots (QDs), carbon base NPs, and nanozymes, exceptionally potent light absorbers and scatterers. These find application in labeling, surface-enhanced spectroscopy, and color-changing sensors. Fluorescent NPs function as photostable and sensitive instruments capable of labeling various biological targets. This article presents a comprehensive summary of the latest developments in the effective utilization of various NPs to detect periodontitis. Graphical Abstract

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Recent Advances in Nanozyme-Based Sensing Technology for Antioxidant Detection

Cao,

Liu,

Wang

et al. 2024

Sensors

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Antioxidants are substances that have the ability to resist or delay oxidative damage. Antioxidants can be used not only for the diagnosis and prevention of vascular diseases, but also for food preservation and industrial production. However, due to the excessive use of antioxidants, it can cause environmental pollution and endanger human health. It can be seen that the development of antioxidant detection technology is important for environment/health maintenance. It is found that traditional detection methods, including high performance liquid chromatography, gas chromatography, etc., have shortcomings such as cumbersome operation and high cost. In contrast, the nanozyme-based detection method features advantages of low cost, simple operation, and rapidity, which has been widely used in the detection of various substances such as glucose and antioxidants. This article focuses on the latest research progress of nanozymes for antioxidant detection. Nanozymes for antioxidant detection are classified according to enzyme-like types. Different types of nanozyme-based sensing strategies and detection devices are summarized. Based on the summary and analysis, one can find that the development of commercial nanozyme-based devices for the practical detection of antioxidants is still challenging. Some emerging technologies (such as artificial intelligence) should be fully utilized to improve the detection sensitivity and accuracy. This article aims to emphasize the application prospects of nanozymes in antioxidant detection and to provide new ideas and inspiration for the development of detection methods.

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The potential use of nanozyme in aging and age‐related diseases

Cited by 5 publications

References 109 publications

The potential use of nanozymes as an antibacterial agents in oral infection, periodontitis, and peri-implantitis

The potential use of nanozymes as an antibacterial agents in oral infection, periodontitis, and peri-implantitis

Recent advances in nanomaterial-based biosensor for periodontitis detection

Recent Advances in Nanozyme-Based Sensing Technology for Antioxidant Detection

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