The potential use of prodigiosin as a shrimp feed additive and its dynamic influence on the shrimp gut microbial community – an in vitro gut model

Suhaimi, Norazurah; Yin, Yulong; Nazari, Teh Faridah; Halim, M. Arief Rahman; Daud, Fareh Nunizawati; Demirtaş, İbrahim; Zarkasi, Kamarul Zaman

doi:10.21161/mjm.180236

Cited by 1 publication

(1 citation statement)

References 25 publications

(47 reference statements)

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“…Finding an antibiofilm agent that can be impaired bacterial biofilm without inducing cell death is remarkable (Da Silva Trentin et al, 2011;Suhaimi et al, 2019). The rapid development of bacterial resistance can be reduced and controlled.…”

Section: Discussionmentioning

confidence: 99%

Antibiofilm activity of Nigrospora sphaerica CL-OP30 endophytic extract against Streptococcus mutans - the causative agent of dental caries

Mokhtar, N. A. A.,

Ibrahim, D.,

Zulfakar, S. S.

et al. 2023

MJM

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Aims:The antibiofilm activity of endophytic fungus Nigrospora sphaerica CL-OP30 isolated from Swietenia macrophylla King was investigated. Methodology and results:The ability of the fungal endophytic crude extract to impede Streptococcus mutans biofilm formation was preliminarily screened with Congo red agar test. It was proven that S. mutans biofilm formation was hindered on the agar supplemented with the fungal endophytic crude extract. The antibiofilm activity of the fungal endophytic crude extract was evaluated using a microtiter plate method on both initially formed and preformed biofilm. Antibiofilm activity was recorded in a concentration-dependent pattern whereby higher concentrations reduced biofilm formation better than the lower concentrations of extract for both initially formed and preformed biofilm. The architecture of biofilm tested with fungal endophytic crude extract was also observed. Visualization under a light microscope and SEM revealed that the adherence of S. mutans biofilm treated with fungal endophytic crude extract was significantly reduced in both initially formed and preformed biofilm. In addition, observation under SEM showed that the matrices surrounding the bacterial cells were disintegrated and bacterial cells in biofilm completely lost their original shape. The overall data demonstrated that the ethyl acetate N. spaherica CL-OP30 crude extract showed good antibiofilm activity. Conclusion, significance and impact of study:The antibiofilm study suggested the potential of N. sphaerica CL-OP30 crude extract against S. mutans biofilm by disrupting the biofilm formation, the disintegration of matrices surrounding the biofilm and responsible for the formation of irregular cell shape. This extract may have a promising potential to be developed as an antibiofilm agent.

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Section: Discussionmentioning

confidence: 99%

Antibiofilm activity of Nigrospora sphaerica CL-OP30 endophytic extract against Streptococcus mutans - the causative agent of dental caries

Mokhtar, N. A. A.,

Ibrahim, D.,

Zulfakar, S. S.

et al. 2023

MJM

View full text Add to dashboard Cite

show abstract

The potential use of prodigiosin as a shrimp feed additive and its dynamic influence on the shrimp gut microbial community – an in vitro gut model

Abstract: The potential use of prodigiosin as a shrimp feed additive and its dynamic influence on the shrimp gut microbial communityan in vitro gut model

Cited by 1 publication

References 25 publications

Antibiofilm activity of Nigrospora sphaerica CL-OP30 endophytic extract against Streptococcus mutans - the causative agent of dental caries

Antibiofilm activity of Nigrospora sphaerica CL-OP30 endophytic extract against Streptococcus mutans - the causative agent of dental caries

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