The potential use of saliva to detect recurrence of disease in women with breast carcinoma

Bigler, Lenora; Streckfus, Charles F.; Copeland, Lynn; Burns, Rebecca; Dai, Xiaoli; Kuhn, Melinda; Martín, Patricia; Bigler, Steven A.

doi:10.1034/j.1600-0714.2002.00123.x

Cited by 78 publications

(65 citation statements)

References 34 publications

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“…Breast cancer mortality level decreased and this has been attributed to: the early diagnosis (characterization of prognosis and diagnosis factors) and the treatment with adjuvant chemotherapy, hormonal therapy and target therapy (Xiaoqiang, 2013). Despite the advanced testing methods, like mammography, these procedures may produce a large percentage of false positives and false negatives, especially in women with dense breast tissues (Bigler et al, 2002;Dilhuydy, 2009;Tarhan et al, 2013). Consequently, studies have big interest in tumor markers, substances detected in the circulation of patients with malignant tumors, which could be used in all stages of cancer care (screening, diagnosis, treatment and metastasis prediction) (Porika et Maric et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Significant Correlation between Salivary and Serum Ca 15-3 in Healthy Women and Breast Cancer Patients

Laidi

Bouziane²,

Lakhdar³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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The tumor marker CA 15-3 is one of the most import reliable for metastatic breast cancer monitoring. While it is generally assessed in serum of patients, blood sampling is an invasive method compared to saliva sampling which is simple and could be an alternative to blood according to many studies. The aim of this investigation was to assess the relationship between serum and salivary concentrations of the protein CA 15-3 in patients with breast cancer and healthy asymptomatic volunteers. A case-control study was conducted with 60 women: 29 breast cancer patients from the Maternity Hospital Souissi Rabat (Morocco) and 31 healthy asymptomatic women. The CA 15-3 concentrations in saliva and serum samples were assessed using an enzyme immune assay (EIA kits) and comparison between cases and controls was made by the Mann-Whitney test. The correlation between serum and saliva CA 15-3 concentration was tested using Pearson correlation. The comparison result of CA15-3 concentration in saliva and serum level in cases and controls was not statistically significant (p>0.05). However, the correlation between salivary and serum CA 15-3 concentration was positive and statistically significant (r=0.27, p=0.03). In conclusion, the positive correlation between salivary and serum expression found in our study suggests that saliva could be an alternative to blood sampling to help breast cancer monitoring.

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Section: Introductionmentioning

confidence: 99%

Significant Correlation between Salivary and Serum Ca 15-3 in Healthy Women and Breast Cancer Patients

Laidi

Bouziane²,

Lakhdar³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…Such an examination might be of great benefit because of the direct contact between the oral cancer lesion and saliva, particularly because salivary analysis is a useful diagnostic tool for other distant malignancies, such as breast carcinoma (24). Moreover, these scarce salivary reports focused only on one commonly analyzed tumor marker, the CEA (25,26), which did not prove to be sensitive or specific enough.…”

mentioning

confidence: 99%

Concomitant Analysis of Salivary Tumor Markers—A New Diagnostic Tool for Oral Cancer

Nagler¹,

Bahar

Shpitzer

et al. 2006

Clinical Cancer Research

185

119

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Purpose: Oral squamous cell carcinoma (OSCC) is a common human malignancy. Circulatory epithelial tumor markers were previously investigated in the serum of OSCC patients but almost never in their saliva, in spite of the fact that there is a direct contact between the saliva and the oral cancer lesion. The purpose of the current study was to examine tumor markers in the saliva of OSCC patients. Experimental Design:We measured the concentrations of the six most studied epithelial serum circulatory tumor markers in the saliva of OSCC (tongue) patients. Results: Significant increases (of 400 %) in salivary concentrations of Cyfra 21-1, tissue polypeptide antigen, and CA125 were shown. Salivary concentrations of CA19-9, SCC, and carcinoembryonic antigen were increased without statistical significance. A concurrent analysis of the three significantly increased markers revealed sensitivity, specificity, and negative and positive predictive values of 71%, 75%, 71%, and 75%, respectively. Conclusions: The increase reported in salivary tumor markers may be used as a diagnostic tool, especially when a concurrent analysis for significantly increased markers is done. Salivary testing is noninvasive, making it an attractive, effective alternative to serum testing, and the possibility of developing home testing kits would further facilitate it as a diagnostic aid, enabling patients to monitor their own health at home and is important for those who live far from their treatment centers and especially for those at risk of developing OSCC.Oral squamous cell carcinoma (OSCC) is a common human malignancy, with an increasing incidence (especially in younger people) and a 5-year mortality rate of f50% (1 -4), which has not changed significantly in >50 years (5 -11). Its location and treatment in the mouth/face/neck result in a relatively high rate of related morbidity, as the treatment frequently results in a significant mutilation and compromised functions. OSCC includes both mobile (oral) and base of tongue cancer lesions. Most often, an oral cancer lesion is located at the lateral border of the tongue, whereas one located at the base of tongue is considered especially lethal. Clinically, it is important to note that the therapeutic modality currently offered to patients is based on traditional stage-predicting indices (based mostly on the tumor-nodemetastasis criteria) and on histologic grading. Unfortunately, these predictors are subjective and relatively unreliable, as often two tumors with identical staging and grading behave in totally different fashions, and although one responds to therapy, the other is lethal. Accordingly, there has been an ever-growing effort dedicated to the basic research of oral cancer, focusing on the identification of biological indicators for the diagnosis of its biological nature and aggressiveness. Circulatory tumor markers for OSCC were investigated in various studies (12 -21) and showed relatively moderate sensitivity and specificity values with relation to diagnosis, prognosis predicti...

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“…A partir da análise em saliva, o fragmento solúvel do oncogene c-erbB-2, um marcador prognóstico do câncer de mama, bem como o antígeno 15-3 para câncer (CA15-3), foram significativamente maiores na saliva e no soro de mulheres com diagnóstico de câncer que o observado em um grupo controle de mulheres saudáveis e indivíduos com tumores benignos. Adicionalmente, o uso do teste salivar pode ser importante no monitoramento dos níveis de c-erbB-2 em pacientes em tratamento quimioterápico e/ou cirúrgico, de forma que serve como avaliação da efetividade terapêutica em questão, bem como, pode ser útil na proservação (BIGLER et al,2002).…”

Section: Doenças Neoplásicas Malignasunclassified

Valor Diagnóstico da Saliva em Doenças Orais e Sistêmicas: Uma Revisão de Literatura

Moura¹,

Medeiros²,

Costa³

et al. 2007

Pesq Bras Odontoped Clin Integr

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Introdução: O valor da saliva como meio de diagnóstico de doenças orais e sistêmicas tem sido objeto de estudo de diversos pesquisadores que têm o intuito de acrescentar uma possibilidade de exame complementar. A análise da saliva, como análises baseadas no uso do sangue, tem duas finalidades: o primeiro, para identificar indivíduos com doença e o segundo, para seguir o progresso do indivíduo afetado, avaliando a efetividade do tratamento empregado. Dentre as vantagens do uso desse recurso podemos enfatizar a facilidade de coleta do material bem como, o seu manuseio, que são pontos importantes na operacionalização técnica desse tipo de exame. A saliva pode ser útil na avaliação do risco de cárie e também no diagnóstico de outras doenças utilizando métodos sialométricos (fluxo salivar) e sialoquímicos, onde determinadas substâncias podem ser dosadas e assim contribuir para o diagnóstico de doenças a partir do exame de níveis de elementos inorgânicos e orgânicos, como dosagens hormonais, pesquisa de agentes biológicos virais, bacterianos e fúngicos, além de marcadores biológicos úteis no diagnóstico e prognóstico do câncer. É necessário se considerar um modelo hierárquico utilizado para avaliação diagnóstica da tecnologia que consiste em cinco níveis básicos da análise em que a eficácia de todo o teste de diagnóstico deve ser avaliada: o analítico, que considera a precisão e a exatidão; a sensibilidade e especificidade diagnóstica; a eficácia do resultado para o paciente baseado na tomada de decisão médica; avaliação operacional, que considera o valor preditivo e a eficiência do teste; e o custo/benefício. Objetivo: Realizar ampla revisão da literatura acerca do uso da saliva como meio de diagnóstico de doenças e monitoração da saúde bucal e sistêmica. Conclusão: Os avanços nos estudos de métodos de diagnóstico que utilizam saliva como meio biológico para o diagnóstico e acompanhamento de condições bucais e sistêmicas apresentam resultados promissores o que poderá constituir um meio de exame usado na rotina.

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The potential use of saliva to detect recurrence of disease in women with breast carcinoma

Abstract: This preliminary study appears to indicate that c-erbB-2 protein expression in saliva may be a very useful diagnostic tool for measuring patient response to chemotherapy and/or surgical treatment of their disease.

Cited by 78 publications

References 34 publications

Significant Correlation between Salivary and Serum Ca 15-3 in Healthy Women and Breast Cancer Patients

Significant Correlation between Salivary and Serum Ca 15-3 in Healthy Women and Breast Cancer Patients

Concomitant Analysis of Salivary Tumor Markers—A New Diagnostic Tool for Oral Cancer

Valor Diagnóstico da Saliva em Doenças Orais e Sistêmicas: Uma Revisão de Literatura

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