The potential utility of fecal (or intestinal) microbiota transplantation in controlling infectious diseases

Ghani, Rohma; Mullish, Benjamin H.; Roberts, Lauren A; Davies, Frances; Marchesi, Julian R.

doi:10.1080/19490976.2022.2038856

Cited by 28 publications

(14 citation statements)

References 170 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Recent advances in analytical techniques have improved our knowledge regarding the relationship between commensal bacteria and intestinal immunity. Microbiota–control interventions with probiotics [ 206 ] and fecal microbiota transplantation (FMT) may be effective in infectious diseases [ 207 , 208 ], but there have been reports of adverse events, and caution may be required [ 209 ], additionally, the differences in indigenous microbiota among nationalities must also be considered. Since interventional studies in humans are limited, in vitro and animal model studies may be useful for research and development [ 69 , 210 , 211 , 212 ].…”

Section: Approaches To the Study Of The Intestinal Microbiota In Infe...mentioning

confidence: 99%

Role of Microbiota in Viral Infections and Pathological Progression

Mizutani

Ishizaka

Koga

et al. 2022

Viruses

View full text Add to dashboard Cite

Viral infections are influenced by various microorganisms in the environment surrounding the target tissue, and the correlation between the type and balance of commensal microbiota is the key to establishment of the infection and pathogenicity. Some commensal microorganisms are known to resist or promote viral infection, while others are involved in pathogenicity. It is also becoming evident that the profile of the commensal microbiota under normal conditions influences the progression of viral diseases. Thus, to understand the pathogenesis underlying viral infections, it is important to elucidate the interactions among viruses, target tissues, and the surrounding environment, including the commensal microbiota, which should have different relationships with each virus. In this review, we outline the role of microorganisms in viral infections. Particularly, we focus on gaining an in-depth understanding of the correlations among viral infections, target tissues, and the surrounding environment, including the commensal microbiota and the gut virome, and discussing the impact of changes in the microbiota (dysbiosis) on the pathological progression of viral infections.

show abstract

Section: Approaches To the Study Of The Intestinal Microbiota In Infe...mentioning

confidence: 99%

Role of Microbiota in Viral Infections and Pathological Progression

Mizutani

Ishizaka

Koga

et al. 2022

Viruses

View full text Add to dashboard Cite

show abstract

“…Due to the success of fecal microbiota transplantation (FMT) in the treatment of Clostridioides difficile infection, the potential use of FMT in treating other infectious diseases has gained interest as an alternative strategy to antibiotics [ 85 ]. The modification of the urobiome in the prevention of UTIs has been suggested.…”

Section: Novel Strategies In the Prevention And Treatment Of Utismentioning

confidence: 99%

Urinary Tract Infections Caused by Uropathogenic Escherichia coli Strains—New Strategies for an Old Pathogen

Zagaglia

Ammendolia²,

Maurizi

et al. 2022

Microorganisms

View full text Add to dashboard Cite

Urinary tract infections (UTIs) are among the most common infections worldwide. Uropathogenic Escherichia coli (UPECs) are the main causative agent of UTIs. UPECs initially colonize the human host adhering to the bladder epithelium. Adhesion is followed by the bacterial invasion of urothelial epithelial cells where they can replicate to form compact aggregates of intracellular bacteria with biofilm-like properties. UPEC strains may persist within epithelial urothelial cells, thus acting as quiescent intracellular bacterial reservoirs (QIRs). It has been proposed that host cell invasion may facilitate both the establishment and persistence of UPECs within the human urinary tract. UPEC strains express a variety of virulence factors including fimbrial and afimbrial adhesins, invasins, iron-acquisition systems, and toxins, which cooperate to the establishment of long lasting infections. An increasing resistance rate relative to the antibiotics recommended by current guidelines for the treatment of UTIs and an increasing number of multidrug resistant UPEC isolates were observed. In order to ameliorate the cure rate and improve the outcomes of patients, appropriate therapy founded on new strategies, as alternative to antibiotics, needs to be explored. Here, we take a snapshot of the current knowledge of coordinated efforts to develop innovative anti-infective strategies to control the diffusion of UPECs.

show abstract

“…Results of this pilot study indicate a significant beneficial effect of FMT to restore the microbiome and decrease long‐term inflammation in PWH. Not only will FMT have a significantly positive impact on the colonization of the gut flora, but it may aid in some restoration of the immune system by increasing the number of peripheral Th17 and Th22 cells and reducing the number of activated CD4+ T cells in the gastrointestinal tissues 9 . Therefore, FMT should be considered for future study and application in relation to standard HIV supplementary treatment alongside combined antiretroviral therapies.…”

Section: Fecal Microbiota Transplantmentioning

confidence: 99%

Human gut microbiome in human immunodeficiency virus and acquired immunodeficiency syndrome‐related diseases: Clinically relevant observations

Higgs

Seely

Brooks

2022

Clinical and Translational Dis

View full text Add to dashboard Cite

The implications of recent discoveries pertaining to immune-mediated disease and the human gut microbiome are vast. In a symbiotic relationship, the immune system modulates the maintenance of host-microbe normobiosis, and the gut microbiome plays a critical role in developing and maintaining the host's innate and adaptive immune systems. The cutting edge of microbiome research and personalized medicine targets the clinical application and exploitation of gut microbiota modulation in the setting of specific diseases. For example, prebiotic/probiotic supplementation, microbiome enhancing diets, and fecal microbiota transplant have been studied as potential ameliorative supplemental interventions to combined antiretroviral therapy (cART) in human immunodeficiency virus-positive (HIV+) individuals. Furthermore, recent evidence shows a positive correlation between improved CD4+ cell counts in HIV+ individuals and improved gut microbiota profile after cART. We supplement this finding with data and supporting evidence from recent studies to aid in the clinical application of these findings in this commentary. Preliminary data support the consideration of the gut microbiota in the proactive management of HIV-associated comorbidities.

show abstract

The potential utility of fecal (or intestinal) microbiota transplantation in controlling infectious diseases

Cited by 28 publications

References 170 publications

Role of Microbiota in Viral Infections and Pathological Progression

Role of Microbiota in Viral Infections and Pathological Progression

Urinary Tract Infections Caused by Uropathogenic Escherichia coli Strains—New Strategies for an Old Pathogen

Human gut microbiome in human immunodeficiency virus and acquired immunodeficiency syndrome‐related diseases: Clinically relevant observations

Contact Info

Product

Resources

About