2015
DOI: 10.3346/jkms.2015.30.3.245
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The Potential Utility of Iodinated Contrast Media (ICM) Skin Testing in Patients with ICM Hypersensitivity

Abstract: Both immediate and delayed hypersensitivity reactions to iodinated contrast media (ICM) are relatively common. However, there are few data to determine the clinical utility of immunologic evaluation of ICM. To evaluate the utility of ICM skin testing in patients with ICM hypersensitivity, 23 patients (17 immediate and 6 delayed reactions) were enrolled from 3 university hospitals in Korea. With 6 commonly used ICM including iopromide, iohexol, ioversol, iomeprol, iopamidol and iodixanol, skin prick (SPT), intr… Show more

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Cited by 33 publications
(45 citation statements)
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“…The SPT was done to evaluate type I IgE-mediated allergy by confirming allergen-specific IgE. 5 It was done on the volar aspect of the forearm, using commercially available topical steroids. 5 7 A 1-mm single-peak lancet with shoulder was used.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…The SPT was done to evaluate type I IgE-mediated allergy by confirming allergen-specific IgE. 5 It was done on the volar aspect of the forearm, using commercially available topical steroids. 5 7 A 1-mm single-peak lancet with shoulder was used.…”
Section: Discussionmentioning
confidence: 99%
“…We observe time-course results every 15 minutes. 1 5 All steroids showed negative open test results after 30 minutes ( Fig. 2 ).…”
Section: Case Descriptionmentioning
confidence: 97%
“…In addition to initiating a lifesaving intervention, clinicians that recognize anaphylactic reactions from contrast media may be more likely to diagnose hypersensitivity syndromes. This can play a role in counseling about necessary precautions since similar pathways can be found in cases of other anaphylaxes (12,13). The mean scores from this study indicate a lack of knowledge regarding contrast agents as well as adverse reaction risk among clinicians in Kenya.…”
Section: Discussionmentioning
confidence: 79%
“…There is high cross-reactivity between different types of RCM agents in patients presenting with anaphylaxis, and a positive skin test. 7 In a recent meta-analysis, 8 cross reactivity between iohexol and iodixanol was reported as 10% (5–23%) based on results of skin test-positive patients, but data is scarce regarding cross-reactivity between iohexol and iodixanol in patients with negative skin testing. Therefore, it is difficult to determine the role of performing desensitization with iodixanol instead of the initial culprit agent, iohexol.…”
Section: Discussionmentioning
confidence: 99%