The potentialities of oxytocin receptor inhibitors for endometriosis therapy

Abstract

Objective: Genital endometriosis (GE) is a widespread gynecological disease which requires its further pathogenesis investigation and search for new effective treatments. The known data of oxytocin receptor presence in endometrioid heterotopy smooth muscle cells give some grounds to assume oxytocin participation in the pathogenesis of endometriosis. The present study objective was to evaluate oxytocin level in peripheral blood (PB) in patients with endometriosis associated pain syndrome and to estimate the efficacy of oxytocin receptor inhibitors (IOXTR) administration based on animal endometriosis model. Materials and methods: The basic group comprised 61 patients with endometriosis associated pain syndrome, while 21 patients formed the control group. VAS, MPQ, and BBS objective tests were applied for pain syndrome evaluation. Oxytocin level in PB was measured by immunoenzyme method. After confirmation of endometriosis experimental model formation in rats and further randomization, a daily IOXTR intra-abdominal injection was performed in a dose of 0.35 mg/kg/24 h in the basic group (n ¼ 12) or saline solution administration in the control (n ¼ 12). On the final stage, endometrioid heterotopy size measuring was performed along with histological examination. Results: Oxytocin level in PB was authentically higher in patients with GE compared to the control: 51.45 (35.54-62.76) pg/mL and 27.64 (23.23-34.12) pg/mL, respectively (p<.001). Positive correlation between oxytocin PB level and pain syndrome expression was established in patients with GE: VAS (r ¼ 0.76; p<.001), MPQ (r ¼ 0.52; p<.001), and BBS (r ¼ 0.57; p<.001). Based on the experimental disease model authentical decrease of endometrioid heterotopy average area was observed after IOXTR therapy compared to the control (7.3 ± 1.8 mm 2 and 22.2 ± 1.2 mm 2 , respectively, p<.05). Conclusions:The obtained results confirm the oxytocin role in the pathogenesis of endometrioid associated pain syndrome. The high efficacy of IOXTR administration based on animal model of surgically induced endometriosis allows viewing this method as a perspective therapy.

Diagnosis, pelvic pain, and medication mediate cognitive empathic abilities among women with endometriosis or polycystic ovary syndrome

“…Guo et al 38 for dysmenorrhea), and lower testosterone (which increases pain sensitivity) (reviewed in Dinsdale et al 6 ), both of which could contribute to higher RMET scores. Indeed, Yarmolinskaya et al 5 reported that compared to unaffected women, women with endometriosis had higher serum oxytocin, and that serum oxytocin levels positively predicted pelvic pain intensity.…”

“…Endometriosis and polycystic ovary syndrome (PCOS), the two most common female reproductive disorders, involve atypical hormonal profiles that contribute to diverse problematic symptoms for affected women. [1][2][3][4][5][6][7][8][9][10] Endometriosis involves the proliferation and inflammation of endometrial or endometrial-like tissue beyond the uterine boundary, 1 with pelvic pain, and risk for the disorder, linked to high levels of estrogen and oxytocin and low testosterone. [2][3][4][5][6] By contrast, PCOS involves irregular or absent ovulation, hirsutism, and polyfollicular ovaries, most of which involve elevated testosterone.…”

“…[1][2][3][4][5][6][7][8][9][10] Endometriosis involves the proliferation and inflammation of endometrial or endometrial-like tissue beyond the uterine boundary, 1 with pelvic pain, and risk for the disorder, linked to high levels of estrogen and oxytocin and low testosterone. [2][3][4][5][6] By contrast, PCOS involves irregular or absent ovulation, hirsutism, and polyfollicular ovaries, most of which involve elevated testosterone. 7,8 Treatments for PCOS frequently involve drugs that reduce testosterone or block androgen activity.…”

Dual Oxytocin Receptor-G Protein Signaling in the Autoregulation of Activities of Oxytocin Neurons

“…For example, excessive OT secretion is associated with preterm labor, prenatal eclampsia, and postpartum hemorrhage [173]. In patients with endometriosis-associated pain syndrome, OT level in peripheral blood is significantly higher; administration of OTR inhibitors can cause authentic decrease of endometrioid heterotopy area as shown in an animal model of surgically induced endometriosis [181]. Excessive OT secretion may delay ovulation and interrupt implantation while embryo transfer can be facilitated by application of OT antagonist atosiban as shown in a patient with cervical stenosis [182] and by a single oral dose of nolasiban in women undergoing in vitro fertilization [183].…”